Publications by authors named "Roger B Dodd"

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Derivation of AZD5335, a Novel FRα-Targeted TOP1i-Loaded ADC, for the Treatment of FRα-Expressing Cancers.
Jason J Zoeller, Ravinder Tammali, Roger B Dodd, Neki V Patel, Alma Andoni

Clin Cancer Res· December 2025

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Transient Transfection of Rolling-Circle Amplified DNA in Biomanufacturing-Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression.
Evelina Loghin, Erik Kvam, Lisa Lowery, Nathan Hudson, Jenny Keen, Roger B Dodd

Biotechnol Appl Biochem· November 2025

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CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk.
Roger B Dodd, Masahiro Enomoto, Ye Zhou, Kanayo Satoh, Yalun Zhang

bioRxiv· July 2025

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Robust Prediction of Relative Binding Energies for Protein-Protein Complex Mutations Using Free Energy Perturbation Calculations.
Jared M Sampson, Daniel A Cannon, Jianxin Duan, Jordan C K Epstein, Alina P Sergeeva, Roger B Dodd

J Mol Biol· August 2024

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Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.
Jared M Sampson, Daniel A Cannon, Jianxin Duan, Jordan C K Epstein, Alina P Sergeeva, Roger B Dodd

bioRxiv· April 2024

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A simeprevir-inducible molecular switch for the control of cell and gene therapies.
Stacey E Chin, Christina Schindler, Lisa Vinall, Roger B Dodd, Lisa Bamber

Nat Commun· November 2023

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Oxidised IL-33 drives COPD epithelial pathogenesis ST2-independent RAGE/EGFR signalling complex.
Sam Strickson, Kirsty F Houslay, Victor A Negri, Yoichiro Ohne, Tomas Ottosson, Roger B Dodd

Eur Respir J· September 2023

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Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.
Anna Vilalta, Ye Zhou, Jean Sevalle, Jennifer K Griffin, Kanayo Satoh, Roger B Dodd

J Biol Chem· August 2021

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Therapeutic Monoclonal Antibodies to Complex Membrane Protein Targets: Antigen Generation and Antibody Discovery Strategies.
Roger B Dodd, Trevor Wilkinson, Darren J Schofield

BioDrugs· August 2018

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An exTREMe disruption in Alzheimer's cleanup.
Roger B Dodd

J Biol Chem· August 2018

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TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
Peter Thornton, Jean Sevalle, Michael J Deery, Graham Fraser, Ye Zhou, Roger B Dodd

EMBO Mol Med· October 2017

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Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.
Stephen P Burr, Ana S H Costa, Guinevere L Grice, Richard T Timms, Ian T Lobb, Roger B Dodd

Cell Metab· November 2016

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ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.
Tetsuro Murakami, Seema Qamar, Julie Qiaojin Lin, Gabriele S Kaminski Schierle, Eric Rees, Roger B Dodd

Neuron· November 2015

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Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.
Yi Li, Stephen Hsueh-Jeng Lu, Ching-Ju Tsai, Christopher Bohm, Seema Qamar, Roger B Dodd

Structure· January 2014

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Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1.
Ioannis Manolaridis, Kiran Kulkarni, Roger B Dodd, Satoshi Ogasawara, Ziguo Zhang

Nature· December 2013

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Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT.
Jing Yang, Kiran Kulkarni, Ioannis Manolaridis, Ziguo Zhang, Roger B Dodd

Mol Cell· December 2011

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Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules.
Lidia M Duncan, Siân Piper, Roger B Dodd, Mark K Saville, Chris M Sanderson

EMBO J· April 2006

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Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain.
Roger B Dodd, Mark D Allen, Stephanie E Brown, Christopher M Sanderson, Lidia M Duncan

J Biol Chem· December 2004

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