Publications by authors named "Roger Hajjar"

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Development of a Flexible Parallel Wire Robot for Epicardial Interventions.
Aman Ladak, Johannes O Bonatti, Roger J Hajjar, Alaaeldin A Shalaby, Cameron N Riviere

Int J Med Robot· February 2026

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The second act of cardiac gene therapy.
Roger J Hajjar, Timothy D Henry

Mol Ther· January 2026

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Cardiotropic AAV gene therapy for heart failure: a phase 1 trial.
Timothy D Henry, Eugene S Chung, Monica Alvisi, Ferzin Sethna, David R Murray, Roger J Hajjar

Nat Med· November 2025

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Gene therapy in cardiac and vascular diseases: a review of approaches to treat genetic and common cardiovascular diseases with novel gene-based therapeutics.
Patricia L Musolino, Susan J Rosser, Mairi Brittan, David E Newby, Colin Berry, Roger J Hajjar

Cardiovasc Res· October 2025

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Pharmacotherapy of cardiovascular diseases from herbs and pills to nucleic acids.
Ulf Landmesser, Thomas Thum, Lale Tokgözoğlu, Tomasz J Guzik, Francesco Cosentino, Roger Hajjar

Eur Heart J· August 2025

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As new cell and gene therapies emerge from academia, we must RISE to the opportunity.
Nandhitha Uma Naresh, Dana Hammill, Mark Kessel, Roger J Hajjar, Nathan L Yozwiak

Nat Biotechnol· January 2025

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AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine.
Renata Mazurek, Serena Tharakan, Spyros A Mavropoulos, Deanndria T Singleton, Olympia Bikou, Roger J Hajjar

Nat Commun· December 2024

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Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis.
Feng Xiao, Ngoc Uyen Nhi Nguyen, Ping Wang, Shujuan Li, Ching-Cheng Hsu, Roger J Hajjar

Circulation· September 2024

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Structure of anellovirus-like particles reveal a mechanism for immune evasion.
Shu-Hao Liou, Rajendra Boggavarapu, Noah R Cohen, Yue Zhang, Ishwari Sharma, Roger J Hajjar

Nat Commun· August 2024

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Inhibition of miR-25 ameliorates cardiac and skeletal muscle dysfunction in aged haploinsufficient (+/-) mice.
Sacha V Kepreotis, Jae Gyun Oh, Mina Park, Jimeen Yoo, Cholong Lee, Roger J Hajjar

Mol Ther Nucleic Acids· June 2024

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Modified mRNA-Mediated Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling.
Min Ho Song, Jimeen Yoo, Do-A Kwon, Elena Chepurko, Sunghye Cho, Roger J Hajjar

Int J Mol Sci· June 2024

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Lin28a cardiomyocyte-specific modified mRNA translation system induces cardiomyocyte cell division and cardiac repair.
Ajit Magadum, Jiacheng Sun, Neha Singh, Ann Anu Kurian, Elena Chepurko, Roger Hajjar

J Mol Cell Cardiol· March 2024

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Exploration of the Noncoding Genome for Human-Specific Therapeutic Targets-Recent Insights at Molecular and Cellular Level.
Wolfgang Poller, Susmita Sahoo, Roger Hajjar, Ulf Landmesser, Anna M Krichevsky

Cells· November 2023

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Extracellular Vesicle-Encapsulated Adeno-Associated Viruses for Therapeutic Gene Delivery to the Heart.
Xisheng Li, Sabrina La Salvia, Yaxuan Liang, Marta Adamiak, Erik Kohlbrenner, Roger J Hajjar

Circulation· August 2023

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Cable Tension Optimization for an Epicardial Parallel Wire Robot.
Aman Ladak, Roger J Hajjar, Srinivas Murali, Jeremy J Michalek, Cameron N Riviere

J Med Device· June 2023

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Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a.
Przemek A Gorski, Ahyoung Lee, Philyoung Lee, Jae Gyun Oh, Peter Vangheluwe, Roger Hajjar

Int J Mol Sci· February 2023

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Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts.
Malgorzata E Rogalska, Elizabeth Vafiadaki, Zoi Erpapazoglou, Kobra Haghighi, Lisa Green, Roger J Hajjar

Metabolism· January 2023

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Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy.
Mohit Kumar, Kobra Haghighi, Sheryl Koch, Jack Rubinstein, Francesca Stillitano, Roger J Hajjar

Int J Mol Sci· January 2023

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Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact.
Jaydev Dave, Nour Raad, Nishka Mittal, Lu Zhang, Anthony Fargnoli, Roger J Hajjar

Cardiovasc Res· December 2022

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SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca.
Bracy Fertig, Jiayue Ling, Edgar E Nollet, Sara Dobi, Tara Busiau, Roger Hajjar

FEBS J· October 2022

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Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies.
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Roger Hajjar

Front Physiol· October 2022

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Endobronchial Aerosolized AAV1.SERCA2a Gene Therapy in a Pulmonary Hypertension Pig Model: Addressing the Lung Delivery Bottleneck.
Olympia Bikou, Serena Tharakan, Kelly P Yamada, Taro Kariya, Jaume Aguero, Roger J Hajjar

Hum Gene Ther· May 2022

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Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium.
Katherine G Phillips, Irene C Turnbull, Roger J Hajjar, Kevin D Costa, Joshua Mayourian

Front Physiol· January 2022

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Inflammation and Heart Failure: Friend or Foe?
Roger J Hajjar, Jane A Leopold

Circulation· October 2021

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Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies.
Manuel Ramos-Kuri, Sri Harika Meka, Fabio Salamanca-Buentello, Roger J Hajjar, Larissa Lipskaia

Biol Res· August 2021

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