Publications by authors named "Rok Humar"

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Stress-NRF2 response axis polarizes tumor macrophages and undermines immunotherapy.
Dominik J Schaer, Nadja Schulthess-Lutz, Livio Baselgia, Kahrisan Kunasingam, Rok Humar

J Immunother Cancer· October 2025

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Navigating Hemolysis and the Renal Implications of Hemoglobin Toxicity in Cardiac Surgery.
Dominik J Schaer, Christian A Schaer, Rok Humar, Florence Vallelian, Reney Henderson

Anesthesiology· December 2024

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C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury.
Kevin Akeret, Bart R Thomson, Subhajit Ghosh, Marc Nolte, Urs Fischer, Rok Humar

Fluids Barriers CNS· November 2024

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Hemorrhage-activated NRF2 in tumor-associated macrophages drives cancer growth, invasion, and immunotherapy resistance.
Dominik J Schaer, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Raphael M Buzzi, Rok Humar

J Clin Invest· December 2023

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Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage: Review and Expert Consensus on Clinical Translation.
Ian Galea, Soham Bandyopadhyay, Diederik Bulters, Rok Humar, Michael Hugelshofer

Stroke· July 2023

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Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity.
Marc Pfefferlé, Irina L Dubach, Raphael M Buzzi, Elena Dürst, Nadja Schulthess-Lutz, Rok Humar

J Immunother Cancer· January 2023

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Erythrophagocytes in hemolytic anemia, wound healing, and cancer.
Rok Humar, Dominik J Schaer, Florence Vallelian

Trends Mol Med· November 2022

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Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia.
Florence Vallelian, Raphael M Buzzi, Marc Pfefferlé, Ayla Yalamanoglu, Irina L Dubach, Rok Humar

Cell Death Differ· August 2022

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The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury.
Kevin Akeret, Raphael M Buzzi, Moritz Saxenhofer, Kathrin Bieri, Deborah Chiavi, Rok Humar

BMC Neurol· July 2022

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Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury.
Kevin Akeret, Raphael M Buzzi, Christian A Schaer, Bart R Thomson, Florence Vallelian, Rok Humar

J Cereb Blood Flow Metab· November 2021

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Acute Hemolysis and Heme Suppress Anti-CD40 Antibody-Induced Necro-Inflammatory Liver Disease.
Marc Pfefferlé, Giada Ingoglia, Christian A Schaer, Kerstin Hansen, Nadja Schulthess, Rok Humar

Front Immunol· October 2021

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Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice.
Ayla Yalamanoglu, Irina L Dubach, Nadja Schulthess, Giada Ingoglia, Delaney C Swindle, Rok Humar

Front Immunol· September 2021

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Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics.
Raphael M Buzzi, Catherine M Owczarek, Kevin Akeret, Andrea Tester, Natasha Pereira, Rok Humar

Mol Pharm· August 2021

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Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes.
Marc Pfefferlé, Giada Ingoglia, Christian A Schaer, Ayla Yalamanoglu, Raphael Buzzi, Rok Humar

J Clin Invest· October 2020

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Determining the Optimal Normalization Factor of Different Target Arteries for ex vivo Vascular Function Experiments: A New Standardized Procedure.
Michael Hugelshofer, Jeremy W Deuel, Raphael M Buzzi, Rok Humar, Dominik J Schaer

J Vasc Res· September 2020

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Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity.
Paul W Buehler, Rok Humar, Dominik J Schaer

Trends Mol Med· July 2020

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Line-selective macrophage activation with an anti-CD40 antibody drives a hemophagocytic syndrome in mice.
Giada Ingoglia, Ayla Yalamanoglu, Marc Pfefferlé, Irina L Dubach, Christian A Schaer, Rok Humar

Blood Adv· June 2020

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Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm.
Michael Hugelshofer, Raphael M Buzzi, Christian A Schaer, Henning Richter, Kevin Akeret, Rok Humar

J Clin Invest· December 2019

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[Not Available].
Rok Humar

Praxis (Bern 1994)· January 2019

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Revisiting the putative role of heme as a trigger of inflammation.
Florence Vallelian, Christian A Schaer, Jeremy W Deuel, Giada Ingoglia, Rok Humar

Pharmacol Res Perspect· April 2018

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Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue.
Katja Drägert, Indranil Bhattacharya, Michael N Hall, Rok Humar, Edouard Battegay

Biochem Biophys Res Commun· April 2016

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Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult.
Fabio Aimi, Stavroula Georgiopoulou, Ina Kalus, Fabienne Lehner, Alica Hegglin, Rok Humar

Sci Rep· December 2015

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Deletion of Rictor in brain and fat alters peripheral clock gene expression and increases blood pressure.
Katja Drägert, Indranil Bhattacharya, Giovanni Pellegrini, Petra Seebeck, Abdelhalim Azzi, Rok Humar

Hypertension· August 2015

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Hypoxia potentiates tumor necrosis factor-α induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in white and brown adipocytes.
Indranil Bhattacharya, Ana Pérez Domínguez, Katja Drägert, Rok Humar, Elvira Haas

Biochem Biophys Res Commun· May 2015

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Systemic protection through remote ischemic preconditioning is spread by platelet-dependent signaling in mice.
Christian E Oberkofler, Perparim Limani, Jae-Hwi Jang, Andreas Rickenbacher, Kuno Lehmann, Rok Humar, Bostjan Humar

Hepatology· October 2014

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