Publications by authors named "Roland A Cooper"

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Characterization of β-Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced Dormant .
Reagan S Haney, Joshua H Butler, Lyric A Wardlaw, Emilio F Merino, Victoria Mendiola, Caitlin A Cooper, Roland A Cooper

ACS Infect Dis· November 2025

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Optimization of Prodiginines as Single-Dose Curative Antimalarials.
Amrendra Kumar, Yuexin Li, Xiaowei Zhang, Mahesh Gaddam, Diana Caridha, Roland A Cooper

J Med Chem· November 2025

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Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance.
Matthew T Klope, Poulami Talukder, Brian R Blank, Sevil Chelebieva, Jun Chen, Roland A Cooper

Sci Adv· August 2025

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Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019-2024.
Martin Okitwi, Stephen Orena, Patrick K Tumwebaze, Thomas Katairo, Yoweri Taremwa, Roland A Cooper

Nat Commun· August 2025

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Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity.
Flore Nardella, Tiantian Jiang, Lushun Wang, Monica J Bohmer, Subhoja Chakraborty, Roland A Cooper

Cell Chem Biol· July 2025

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Development of Next-Generation Antimalarial Acridones with Radical Cure Potential.
Rozalia A Dodean, Yuexin Li, Xiaowei Zhang, Diana Caridha, Michael S Madejczyk, Roland A Cooper

J Med Chem· April 2025

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Changes in susceptibility of to antimalarial drugs in Uganda over time: 2019-2024.
Martin Okitwi, Stephen Orena, Patrick K Tumwebaze, Thomas Katairo, Yoweri Taremwa, Roland A Cooper

medRxiv· January 2025

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Tambjamines as Fast-Acting Multistage Antimalarials.
Amrendra Kumar, Yuexin Li, Rozalia A Dodean, Alison Roth, Diana Caridha, Roland A Cooper

ACS Infect Dis· December 2024

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The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh isolates.
Martin Okitwi, Douglas A Shoue, Lisa A Checkley, Stephen Orena, Frida G Ceja, Roland A Cooper

Antimicrob Agents Chemother· December 2024

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Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.
Paula-Josefina Gomez-Gonzalez, Antima Gupta, Laura G Drought, Avnish Patel, John Okombo, Roland A Cooper

Sci Adv· December 2024

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susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan isolates.
Oriana Kreutzfeld, Stephen Orena, Martin Okitwi, Patrick K Tumwebaze, Oswald Byaruhanga, Roland A Cooper

Antimicrob Agents Chemother· September 2024

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drug susceptibility and resistance mediating genetic polymorphisms of in Bobo-Dioulasso, Burkina Faso.
A Fabrice Somé, Melissa D Conrad, Zachari Kabré, Aminata Fofana, R Serge Yerbanga, Roland A Cooper

Antimicrob Agents Chemother· April 2024

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Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases.
Lushun Wang, Monica J Bohmer, Jinhua Wang, Flore Nardella, Jaeson Calla, Roland A Cooper

J Med Chem· January 2024

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Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda.
Melissa D Conrad, Victor Asua, Shreeya Garg, David Giesbrecht, Karamoko Niaré, Roland A Cooper

N Engl J Med· August 2023

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Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline.
Oriana Kreutzfeld, Patrick K Tumwebaze, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Roland A Cooper

Microbiol Spectr· June 2023

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Structure-Activity Relationship Studies of Antimalarial Proteasome Inhibitors─Part II.
Hao Zhang, John Ginn, Wenhu Zhan, Annie Leung, Yi J Liu, Roland A Cooper

J Med Chem· January 2023

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Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.
Shreeya Garg, Oriana Kreutzfeld, Sevil Chelebieva, Patrick K Tumwebaze, Oswald Byaruhanga, Roland A Cooper

Antimicrob Agents Chemother· October 2022

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Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda.
Patrick K Tumwebaze, Melissa D Conrad, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Roland A Cooper

Nat Commun· October 2022

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Impact of Short-Term Storage on Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum Isolates.
Martin Okitwi, Stephen Orena, Katairo Thomas, Patrick K Tumwebaze, Oswald Byaruhanga, Roland A Cooper

Antimicrob Agents Chemother· April 2022

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Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
Laura E de Vries, Patrick A M Jansen, Catalina Barcelo, Justin Munro, Julie M J Verhoef, Roland A Cooper

Nat Commun· April 2022

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Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
Benjamin R Taft, Fumiaki Yokokawa, Tom Kirrane, Anne-Catherine Mata, Richard Huang, Roland A Cooper

J Med Chem· March 2022

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Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates.
Oriana Kreutzfeld, Patrick K Tumwebaze, Oswald Byaruhanga, Thomas Katairo, Martin Okitwi, Roland A Cooper

J Infect Dis· February 2022

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Can repurposing drugs play a role in malaria control?
Roland A Cooper, Laura Kirkman

J Exp Med· December 2021

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Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.
Oriana Kreutzfeld, Stephanie A Rasmussen, Aarti A Ramanathan, Patrick K Tumwebaze, Oswald Byaruhanga, Roland A Cooper

Antimicrob Agents Chemother· September 2021

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Drug susceptibility of in eastern Uganda: a longitudinal phenotypic and genotypic study.
Patrick K Tumwebaze, Thomas Katairo, Martin Okitwi, Oswald Byaruhanga, Stephen Orena, Roland A Cooper

Lancet Microbe· September 2021

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