Publications by authors named "Roland Wolf"

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Humanization of Drug Metabolism in the Mouse Model for Antimalarial Drug Discovery.
A Kenneth MacLeod, Cristina Merino, Sara Viera-Morilla, Laura Frame, Amy Tavendale, C Roland Wolf

ACS Infect Dis· December 2025

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Integration of in vivo stress reporters with transcription profiling to define chemical mixtures mechanisms of toxicity, including trans-generational effects.
Francisco Inesta-Vaquera, Wenduo Qi, Silviya Dimova-Vasileva, G Jean Campbell, Febe Ferro, C Roland Wolf

Chem Biol Interact· November 2025

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AKT/mTOR as a targetable hub to overcome multimodal resistance to EGFR inhibitors in oesophageal squamous cell carcinoma.
Lindsay C Spender, Dale M Watt, Mark A Baxter, Morven K Shuttleworth, Kateah Walker, C Roland Wolf

Br J Cancer· September 2025

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Potential of stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies.
Francisco Iñesta Vaquera, Febe Ferro, Michael McMahon, Colin J Henderson, C Roland Wolf

F1000Res· July 2025

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The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals.
C J Henderson, A W McLaren, A K MacLeod, D Lin, A R Cameron, C Roland Wolf

Arch Toxicol· May 2025

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Use of an extensively humanized mouse model to predict the risk of drug-drug interactions in patients receiving dexamethasone.
Jacob George, James D Chalmers, Kevin-Sebastien Coquelin, Laura Frame, Colin J Henderson, C Roland Wolf

J Pharmacol Exp Ther· February 2025

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Novel TDP-43 stress reporter models to accelerate drug development in ALS.
Febe Ferro, C Roland Wolf, Christopher Henstridge, Francisco Inesta-Vaquera

Open Biol· October 2024

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Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies.
Alice De Carli, Yury Kapelyukh, Jochen Kursawe, Mark A J Chaplain, C Roland Wolf

NPJ Syst Biol Appl· May 2024

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Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism.
A Kenneth MacLeod, Kevin-Sebastien Coquelin, Leticia Huertas, Frederick R C Simeons, Jennifer Riley, C Roland Wolf

Proc Natl Acad Sci U S A· February 2024

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Defining the in vivo mechanism of air pollutant toxicity using murine stress response biomarkers.
Francisco Inesta-Vaquera, Lisa Miyashita, Jonathan Grigg, Colin J Henderson, C Roland Wolf

Sci Total Environ· August 2023

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Improving the predictive power of xenograft and syngeneic anti-tumour studies using mice humanised for pathways of drug metabolism.
Colin J Henderson, Aileen W McLaren, Yury Kapelyukh, C Roland Wolf

F1000Res· April 2023

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Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism.
Lesley A Stanley, C Roland Wolf

Drug Metab Rev· February 2022

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Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling.
Sara J Hamis, Yury Kapelyukh, Aileen McLaren, Colin J Henderson, C Roland Wolf

Br J Cancer· November 2021

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Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2.
Cheryl van de Wetering, Allison M Manuel, Mona Sharafi, Reem Aboushousha, Xi Qian, C Roland Wolf

Redox Biol· November 2021

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Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer.
Elena V Knatko, Cecilia Castro, Maureen Higgins, Ying Zhang, Tadashi Honda, C Roland Wolf

Commun Biol· September 2021

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Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity.
Francisco Inesta-Vaquera, Panida Navasumrit, Colin J Henderson, Tanya G Frangova, Tadashi Honda, C Roland Wolf

Environ Pollut· February 2021

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Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion.
Antonio Vitobello, Juliane Perner, Johanna Beil, Jiang Zhu, Alberto Del Río-Espínola, C Roland Wolf

Life Sci Alliance· October 2019

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Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.
Lindsay Reed, Radek Indra, Iveta Mrizova, Michaela Moserova, Heinz H Schmeiser, C Roland Wolf

Toxicol Appl Pharmacol· March 2019

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Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes.
Michael McMahon, Shaohong Ding, Lourdes Acosta Jimenez, Remi Terranova, Marie-Apolline Gerard, C Roland Wolf

Mol Pharmacol· January 2019

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Discovery of common and rare genetic risk variants for colorectal cancer.
Jeroen R Huyghe, Stephanie A Bien, Tabitha A Harrison, Hyun Min Kang, Sai Chen, Wolfgang Lieb, C Roland Wolf

Nat Genet· January 2019

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Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy.
A Kenneth MacLeod, De Lin, Jeffrey T-J Huang, Lesley A McLaughlin, Colin J Henderson, C Roland Wolf

Clin Cancer Res· May 2018

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Cytochrome b impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b /P450 reductase null (HBRN) mice.
Lindsay Reed, Iveta Mrizova, Frantisek Barta, Radek Indra, Michaela Moserova, C Roland Wolf

Arch Toxicol· April 2018

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Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations.
Harsh Sheth, Emma Northwood, Cornelia M Ulrich, Dominique Scherer, Faye Elliott, C Roland Wolf

PLoS One· April 2018

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Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse.
Michael McMahon, Shaohong Ding, Lourdes P Acosta-Jimenez, Tania G Frangova, Colin J Henderson, C Roland Wolf

J Physiol· January 2018

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Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites.
De Lin, Rumen Kostov, Jeffrey T-J Huang, Colin J Henderson, C Roland Wolf

J Pharmacol Exp Ther· October 2017

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