Publications by authors named "Rolf Hartmann"

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Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity.
Ahmed S Abdelsamie, Mostafa M Hamed, Christian Schütz, Teresa Röhrig, Andreas M Kany, Rolf W Hartmann

Eur J Med Chem· October 2024

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Inhibitors of the Elastase LasB for the Treatment of Lung Infections.
Jelena Konstantinović, Andreas M Kany, Alaa Alhayek, Ahmed S Abdelsamie, Asfandyar Sikandar, Rolf W Hartmann

ACS Cent Sci· December 2023

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Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.
Mostafa M Hamed, Ahmed S Abdelsamie, Katharina Rox, Christian Schütz, Andreas M Kany, Rolf W Hartmann

Adv Sci (Weinh)· February 2023

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Modeling the Effect of Hydrophobicity on the Passive Permeation of Solutes across a Bacterial Model Membrane.
Carla F Sousa, Mohamed A M Kamal, Robert Richter, Kalanika Elamaldeniya, Rolf W Hartmann

J Chem Inf Model· October 2022

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Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from .
Cansu Kaya, Isabell Walter, Alaa Alhayek, Roya Shafiei, Gwenaëlle Jézéquel, Rolf W Hartmann

ACS Infect Dis· May 2022

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Metabolic Profiling of -praziquantel: Structure Elucidation Using the Crystalline Sponge Method in Combination with Mass Spectrometry and Nuclear Magnetic Resonance.
Lara Rosenberger, Judith Jenniches, Carolina von Essen, Anupam Khutia, Clemens Kühn, Rolf W Hartmann

Drug Metab Dispos· April 2022

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-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases.
Cansu Kaya, Jelena Konstantinović, Andreas M Kany, Anastasia Andreas, Jan S Kramer, Rolf W Hartmann

J Med Chem· March 2022

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Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.
Cansu Kaya, Isabell Walter, Samir Yahiaoui, Asfandyar Sikandar, Alaa Alhayek, Rolf W Hartmann

Angew Chem Int Ed Engl· January 2022

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17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.
Emanuele M Gargano, Abdelrahman Mohamed, Ahmed S Abdelsamie, Giuseppe F Mangiatordi, Hanna Drzewiecka, Rolf W Hartmann

ACS Med Chem Lett· December 2021

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Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors.
Isabell Walter, Sebastian Adam, Maria Virginia Gentilini, Andreas M Kany, Christian Brengel, Rolf W Hartmann

ChemMedChem· September 2021

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Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis.
Lara Rosenberger, Carolina von Essen, Anupam Khutia, Clemens Kühn, Katrin Georgi, Rolf W Hartmann

Eur J Pharm Sci· September 2021

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A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.
Christian Schütz, Duy-Khiet Ho, Mostafa Mohamed Hamed, Ahmed Saad Abdelsamie, Teresa Röhrig, Rolf Wolfgang Hartmann

Adv Sci (Weinh)· June 2021

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Phosphonate as a Stable Zinc-Binding Group for "Pathoblocker" Inhibitors of Clostridial Collagenase H (ColH).
Katrin Voos, Esther Schönauer, Alaa Alhayek, Jörg Haupenthal, Anastasia Andreas, Rolf W Hartmann

ChemMedChem· April 2021

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From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
Mohammad Abdel-Halim, Sara Sigler, Nora A S Racheed, Amr Hefnawy, Reem K Fathalla, Rolf W Hartmann

J Med Chem· April 2021

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Homology modeling meets site-directed mutagenesis: An ideal combination to elucidate the topology of 17β-HSD2.
Christoph P Sager, Susanne Weber, Matthias Negri, Pauline Banachowicz, Gabriele Möller, Rolf W Hartmann

J Steroid Biochem Mol Biol· February 2021

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Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors.
Mohammad Abdel-Halim, Heather Tinsley, Adam B Keeton, Mohammed Weam, Noha H Atta, Rolf W Hartmann

Bioorg Chem· November 2020

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Evaluation of Bacterial RNA Polymerase Inhibitors in a -Based Wound Infection Model in SKH1 Mice.
Jörg Haupenthal, Yannik Kautz, Walid A M Elgaher, Linda Pätzold, Teresa Röhrig, Rolf W Hartmann

ACS Infect Dis· October 2020

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Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection.
Xabier Murgia, Andreas M Kany, Christian Herr, Duy-Khiet Ho, Chiara De Rossi, Rolf W Hartmann

Sci Rep· October 2020

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Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction.
Fabian Mayr, Gabriele Möller, Ulrike Garscha, Jana Fischer, Patricia Rodríguez Castaño, Rolf W Hartmann

Int J Mol Sci· September 2020

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A hydrogel-based assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria.
Robert Richter, Mohamed A M Kamal, Mariel A García-Rivera, Jerome Kaspar, Maximilian Junk, Rolf W Hartmann

Mater Today Bio· September 2020

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-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Elastase and Collagenases.
Jelena Konstantinović, Samir Yahiaoui, Alaa Alhayek, Jörg Haupenthal, Esther Schönauer, Rolf W Hartmann

J Med Chem· August 2020

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Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols.
Nicolas Lebouvier, Fabrice Pagniez, Young Min Na, Da Shi, Patricia Pinson, Rolf W Hartmann

Pharmaceuticals (Basel)· August 2020

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Crystalline Sponges as a Sensitive and Fast Method for Metabolite Identification: Application to Gemfibrozil and its Phase I and II Metabolites.
Lara Rosenberger, Carolina von Essen, Anupam Khutia, Clemens Kühn, Klaus Urbahns, Rolf W Hartmann

Drug Metab Dispos· July 2020

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Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics.
Walid A M Elgaher, Mostafa M Hamed, Sascha Baumann, Jennifer Herrmann, Lorenz Siebenbürger, Rolf W Hartmann

Chemistry· June 2020

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Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections.
Duy-Khiet Ho, Xabier Murgia, Chiara De Rossi, Rebekka Christmann, Antonio G Hüfner de Mello Martins, Rolf W Hartmann

Angew Chem Int Ed Engl· June 2020

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