Publications by authors named "Katrin Georgi"

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Non-Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece.
Graeme C Young, Douglas K Spracklin, Alexander D James, Mette G Hvenegaard, Mette L Pedersen, Katrin Georgi

Clin Pharmacol Ther· May 2024

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Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds.
Lena C Preiss, Katrin Georgi, Volker M Lauschke, Carl Petersson

Drug Metab Dispos· May 2024

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Recommendations on the Use of Multiple Labels in Human Mass Balance Studies.
Filip Cuyckens, Mette G Hvenegaard, Kenneth C Cassidy, Douglas K Spracklin, Alexander D James, Katrin Georgi

Drug Metab Dispos· February 2024

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Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective.
Holger Scheible, Hanno Schieferstein, Ralf Schmidt, Klaus Pusecker, Ulrike Gradhand, Katrin Georgi

Xenobiotica· December 2023

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Considerations for Human ADME Strategy and Design Paradigm Shift(s) - An Industry White Paper.
Graeme C Young, Douglas K Spracklin, Alexander D James, Mette G Hvenegaard, Graeme Scarfe, Katrin Georgi

Clin Pharmacol Ther· April 2023

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Increasing the Reuse of Protein Non-Naïve Nonhuman Primates in Pharmaceutical Drug Discovery and Development: An Overview and Industry Position on the Challenges and Benefits.
Charles Mattis, Natalie Bratcher, Monika Burns, Christopher Carosino, Christina de Zafra, Katrin Georgi

Int J Toxicol· August 2022

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Metabolic Profiling of -praziquantel: Structure Elucidation Using the Crystalline Sponge Method in Combination with Mass Spectrometry and Nuclear Magnetic Resonance.
Lara Rosenberger, Judith Jenniches, Carolina von Essen, Anupam Khutia, Clemens Kühn, Katrin Georgi

Drug Metab Dispos· April 2022

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Multi-Well Array Culture of Primary Human Hepatocyte Spheroids for Clearance Extrapolation of Slowly Metabolized Compounds.
Lena C Preiss, Volker M Lauschke, Katrin Georgi, Carl Petersson

AAPS J· March 2022

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Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity.
Hui Qiu, Zahid Ali, Julian Bowlan, Richard Caldwell, Anna Gardberg, Katrin Georgi

ChemMedChem· December 2021

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Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
Lizbeth DeSelm, Bayard Huck, Ruoxi Lan, Constantin Neagu, Justin Potnick, Katrin Georgi

J Med Chem· October 2021

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Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis.
Lara Rosenberger, Carolina von Essen, Anupam Khutia, Clemens Kühn, Katrin Georgi

Eur J Pharm Sci· September 2021

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Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
Lena C Preiss, Ruoqi Liu, Philip Hewitt, David Thompson, Katrin Georgi

Drug Metab Dispos· August 2021

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Crystalline Sponges as a Sensitive and Fast Method for Metabolite Identification: Application to Gemfibrozil and its Phase I and II Metabolites.
Lara Rosenberger, Carolina von Essen, Anupam Khutia, Clemens Kühn, Klaus Urbahns, Katrin Georgi

Drug Metab Dispos· July 2020

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Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation.
Claire C Berthelot, Shizuo George Kamita, Romina Sacchi, Jun Yang, Malin L Nording, Katrin Georgi

PLoS One· June 2016

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Pharmacophore-based design of novel oxadiazoles as selective sphingosine-1-phosphate (S1P) receptor agonists with in vivo efficacy.
Anna Quattropani, Wolfgang H B Sauer, Stefano Crosignani, Jerome Dorbais, Patrick Gerber, Katrin Georgi

ChemMedChem· April 2015

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Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.
Aurélie Mallinger, Simon Crumpler, Mark Pichowicz, Dennis Waalboer, Mark Stubbs, Katrin Georgi

J Med Chem· February 2015

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Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids.
Malin L Nording, Jun Yang, Katrin Georgi, Christine Hegedus Karbowski, J Bruce German

PLoS One· August 2014

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Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.
Jérôme Molette, Julie Routier, Nada Abla, Dominique Besson, Agnes Bombrun, Katrin Georgi

ACS Med Chem Lett· November 2013

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Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations.
Angela M Zivkovic, Jun Yang, Katrin Georgi, Christine Hegedus, Malin L Nording

Metabolomics· December 2012

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Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry.
Jun Yang, Kara Schmelzer, Katrin Georgi, Bruce D Hammock

Anal Chem· October 2009

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Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways.
Bora Inceoglu, Steven L Jinks, Arzu Ulu, Christine M Hegedus, Katrin Georgi

Proc Natl Acad Sci U S A· December 2008

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Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat.
Mandi J Corenblum, Vance E Wise, Katrin Georgi, Bruce D Hammock, Peter A Doris

Hypertension· February 2008

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