Publications by authors named "Carl Petersson"

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Discovery of ART5537: A Potent and Selective Small-Molecule Probe for EXO1.
Sam E Mann, Owen A Davis, Jörg Bomke, Irina Cornaciu, Elias Elinati, Carl Petersson

J Med Chem· December 2025

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Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.
Timo Heinrich, Alessia Gambardella, Daniel Schwarz, Carl Petersson, Jakub Gunera

J Med Chem· November 2025

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Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor.
Sam E Mann, Julien Lefranc, Omar Alkhatib, Roch Boivin, Jörg Bomke, Carl Petersson

J Med Chem· October 2025

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Author Correction: Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.
Christian Sommerauer, Carlos J Gallardo-Dodd, Christina Savva, Linnea Hases, Madeleine Birgersson, Carl Petersson

Mol Syst Biol· September 2025

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M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer.
Christina Esdar, Nina Linde, Andreas Blum, Hanno Schieferstein, Christine Drechsler, Carl Petersson

Mol Cancer Ther· July 2025

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Evaluation of small interfering RNA-dependent knockdowns of drug-metabolizing enzymes in multiwell array culture of primary human hepatocyte spheroids for estimation of fraction metabolized.
Lena Brücker, Dominik Jacob, Lena C Preiss, Yi Zhong, Felix Geist, Carl Petersson

Drug Metab Dispos· April 2025

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Beyond-Rule-of-Five Compounds Are Not Different: In Vitro-In Vivo Extrapolation of Female CD-1 Mouse Clearance Based on Merck Healthcare KGaA Compound Set.
Christine K Maurer, Zhizhou Fang, Heide M Duevel, Stephanie Harlfinger, Carl Petersson

Pharmaceuticals (Basel)· April 2025

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MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.
Timo Heinrich, Daniel Schwarz, Carl Petersson, Jakub Gunera, Sakshi Garg

J Med Chem· March 2025

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and ADME of heterobifunctional degraders: a tailored approach to optimize DMPK properties of PROTACs©.
Christine Katharina Maurer, Zhizhou Fang, Christina Schindler, Gianna Pohl, Fouzia Machrouhi-Porcher, Carl Petersson

RSC Med Chem· February 2025

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Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold.
Emma Carswell, Timo Heinrich, Carl Petersson, Jakub Gunera, Sakshi Garg

Bioorg Med Chem Lett· December 2024

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Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds.
Lena C Preiss, Katrin Georgi, Volker M Lauschke, Carl Petersson

Drug Metab Dispos· May 2024

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Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.
Christian Sommerauer, Carlos J Gallardo-Dodd, Christina Savva, Linnea Hases, Madeleine Birgersson, Carl Petersson

Mol Syst Biol· April 2024

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Comparative analysis of YAP/TEAD inhibitors in 2D and 3D cultures of primary human hepatocytes reveals a novel non-canonical mechanism of CYP induction.
Nuria Oliva-Vilarnau, Sabine U Vorrink, Florian A Büttner, Timo Heinrich, Janike Sensbach, Carl Petersson

Biochem Pharmacol· September 2023

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Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors.
Andreas Blum, Dieter Dorsch, Nina Linde, Susanne Brandstetter, Hans-Peter Buchstaller, Carl Petersson

J Med Chem· February 2023

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Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.
Carl Petersson, Xin Zhou, Joerg Berghausen, David Cebrian, Michael Davies

AAPS J· July 2022

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Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model.
Eva Sherbetjian, Sheila-Annie Peters, Carl Petersson

Xenobiotica· July 2022

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Multi-Well Array Culture of Primary Human Hepatocyte Spheroids for Clearance Extrapolation of Slowly Metabolized Compounds.
Lena C Preiss, Volker M Lauschke, Katrin Georgi, Carl Petersson

AAPS J· March 2022

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Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
Lena C Preiss, Ruoqi Liu, Philip Hewitt, David Thompson, Katrin Georgi, Carl Petersson

Drug Metab Dispos· August 2021

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Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.
Timo Heinrich, Ada Sala-Hojman, Roberta Ferretti, Carl Petersson, Stefano Minguzzi

J Med Chem· August 2021

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Sensitization to storage proteins in peanut and hazelnut is associated with higher levels of inflammatory markers in asthma.
Jennifer Johnson, Andrei Malinovschi, Jonas Lidholm, Carl Johan Petersson, Lennart Nordvall

Clin Mol Allergy· June 2020

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Prediction of active human dose: learnings from 20 years of Merck KGaA experience, illustrated by case studies.
Sheila Annie Peters, Carl Petersson, Andree Blaukat, Joern-Peter Halle, Hugues Dolgos

Drug Discov Today· May 2020

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Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery.
Carl Petersson, Orestis Papasouliotis, Marc Lecomte, Lassina Badolo, Hugues Dolgos

Xenobiotica· March 2020

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Determination of low intrinsic clearance in vitro: the benefit of a novel internal standard in human hepatocyte incubations.
Ugo Zanelli, Thomas Michna, Carl Petersson

Xenobiotica· April 2019

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In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development.
Franco Lombardo, Prashant V Desai, Rieko Arimoto, Kelly E Desino, Holger Fischer, Carl Petersson

J Med Chem· November 2017

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Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy.
Mizuho Nagao, Magnus P Borres, Mayumi Sugimoto, Carl Johan Petersson, Satoshi Nakayama

Clin Mol Allergy· March 2017

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