Publications by authors named "Emma Carswell"

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MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.
Timo Heinrich, Daniel Schwarz, Carl Petersson, Jakub Gunera, Sakshi Garg, Emma Carswell

J Med Chem· March 2025

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Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold.
Emma Carswell, Timo Heinrich, Carl Petersson, Jakub Gunera, Sakshi Garg

Bioorg Med Chem Lett· December 2024

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Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead .
Timo Heinrich, Carl Peterson, Richard Schneider, Sakshi Garg, Daniel Schwarz, Emma Carswell

J Med Chem· July 2022

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Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants.
Zahid Hussain, Andrew J Cooke, Santhosh Neelamkavil, Lindsay Brown, Emma Carswell

Bioorg Med Chem Lett· August 2020

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Imidazopyridyl compounds as aldosterone synthase inhibitors.
Brent R Whitehead, Michael M-C Lo, Amjad Ali, Min K Park, Scott B Hoyt, Emma Carswell

Bioorg Med Chem Lett· January 2017

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N-Substituted tertiary and O-substituted quaternary carbon stereogenic centers by site-, diastereo- and enantioselective vinylogous Mannich reactions.
Daniel L Silverio, Peng Fu, Emma L Carswell, Marc L Snapper, Amir H Hoveyda

Tetrahedron Lett· June 2015

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Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
Scott B Hoyt, Min K Park, Clare London, Yusheng Xiong, Jim Tata, Emma Carswell

ACS Med Chem Lett· May 2015

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High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.
Xavier Fradera, Bert Kazemier, Emma Carswell, Andrew Cooke, Arthur Oubrie

Acta Crystallogr Sect F Struct Biol Cryst Commun· April 2012

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Si-free enolate Claisen rearrangements of enamido substrates.
Wesley R R Harker, Emma L Carswell, David R Carbery

Org Biomol Chem· February 2012

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A practical protocol for the highly E-selective formation of aryl-substituted silylketene acetals.
Wesley R R Harker, Emma L Carswell, David R Carbery

Org Lett· August 2010

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A highly efficient and practical method for catalytic asymmetric vinylogous Mannich (AVM) reactions.
Emma L Carswell, Marc L Snapper, Amir H Hoveyda

Angew Chem Int Ed Engl· November 2006

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Practical and highly enantioselective synthesis of beta-alkynyl-beta-amino esters through Ag-catalyzed asymmetric mannich reactions of silylketene acetals and alkynyl imines.
Nathan S Josephsohn, Emma L Carswell, Marc L Snapper, Amir H Hoveyda

Org Lett· June 2005

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