Publications by authors named "Timo Heinrich"

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Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma.
Nathalie Babl, Florian Voll, Agnieszka Martowicz, Christina Bruss, Marianna Maddaloni, Timo Heinrich

Cancer Lett· December 2025

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Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.
Timo Heinrich, Alessia Gambardella, Daniel Schwarz, Carl Petersson, Jakub Gunera

J Med Chem· November 2025

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Synthesis of Sulfondiimidoates by Desoxychlorination of Sulfonimidamides.
Erik Friedrich, Philip Freund, Christian Lorenz, Timo Heinrich, Dorian Didier

Org Lett· October 2025

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MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.
Timo Heinrich, Daniel Schwarz, Carl Petersson, Jakub Gunera, Sakshi Garg

J Med Chem· March 2025

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Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold.
Emma Carswell, Timo Heinrich, Carl Petersson, Jakub Gunera, Sakshi Garg

Bioorg Med Chem Lett· December 2024

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Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models.
Manja Friese-Hamim, Maria J Ortiz Ruiz, Olga Bogatyrova, Marina Keil, Felix Rohdich, Timo Heinrich

Mol Cancer Ther· February 2024

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MCT4 blockade increases the efficacy of immune checkpoint blockade.
Nathalie Babl, Sonja-Maria Decking, Florian Voll, Michael Althammer, Ada Sala-Hojman, Timo Heinrich

J Immunother Cancer· October 2023

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Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance.
Ana C F Paiva, Ana R Lemos, Philipp Busse, Madalena T Martins, Diana O Silva, Timo Heinrich

Biosensors (Basel)· October 2023

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Comparative analysis of YAP/TEAD inhibitors in 2D and 3D cultures of primary human hepatocytes reveals a novel non-canonical mechanism of CYP induction.
Nuria Oliva-Vilarnau, Sabine U Vorrink, Florian A Büttner, Timo Heinrich, Janike Sensbach

Biochem Pharmacol· September 2023

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MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core.
Martin Schröder, Matthias Leiendecker, Ulrich Grädler, Juliane Braun, Andreas Blum, Timo Heinrich

J Med Chem· January 2023

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Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead .
Timo Heinrich, Carl Peterson, Richard Schneider, Sakshi Garg, Daniel Schwarz

J Med Chem· July 2022

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Synthesis and crystal structure of -2-(1,3-dioxo-isoindolin-2-yl)ethyl 4-methyl--phenyl-'-(tri-iso-propyl-sil-yl)benzene-sulfondiimidoate: the first member of a new substance class.
Erik Friedrich, Timo Heinrich, Lara Rosenberger, Mireille Krier, Stephanie Marek

Acta Crystallogr E Crystallogr Commun· July 2022

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Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.
Timo Heinrich, Ada Sala-Hojman, Roberta Ferretti, Carl Petersson, Stefano Minguzzi

J Med Chem· August 2021

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Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
Benedict-Tilman Berger, Marta Amaral, Daria B Kokh, Ariane Nunes-Alves, Djordje Musil, Timo Heinrich

Cell Chem Biol· May 2021

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Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor : A Clinical Compound for the Treatment of Cancer.
Timo Heinrich, Jeyaprakashnarayanan Seenisamy, Frank Becker, Beatrix Blume, Jörg Bomke

J Med Chem· December 2019

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Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors.
Timo Heinrich, Jeyaprakashnarayanan Seenisamy, Beatrix Blume, Jörg Bomke, Michel Calderini

J Med Chem· May 2019

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Higher-order risk preferences in social settings.
Timo Heinrich, Thomas Mayrhofer

Exp Econ· September 2017

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Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates.
Timo Heinrich, Hans-Peter Buchstaller, Bertram Cezanne, Felix Rohdich, Jörg Bomke

Bioorg Med Chem Lett· February 2017

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Discovery of novel 7-azaindoles as PDK1 inhibitors.
Margarita Wucherer-Plietker, Eugen Merkul, Thomas J J Müller, Christina Esdar, Thorsten Knöchel, Timo Heinrich

Bioorg Med Chem Lett· July 2016

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Fragment-based discovery of focal adhesion kinase inhibitors.
Ulrich Grädler, Jörg Bomke, Djordje Musil, Verena Dresing, Martin Lehmann, Timo Heinrich

Bioorg Med Chem Lett· October 2013

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Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.
Timo Heinrich, Jeyaprakashnarayanan Seenisamy, Lourdusamy Emmanuvel, Santosh S Kulkarni, Jörg Bomke

J Med Chem· February 2013

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Allosteric IGF-1R Inhibitors.
Timo Heinrich, Ulrich Grädler, Henning Böttcher, Andree Blaukat, Adam Shutes

ACS Med Chem Lett· August 2010

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Syntheses of novel 2,3-diaryl-substituted 5-cyano-4-azaindoles exhibiting c-Met inhibition activity.
Hannes Koolman, Timo Heinrich, Henning Böttcher, Wilfried Rautenberg, Michael Reggelin

Bioorg Med Chem Lett· April 2009

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Asymmetric synthesis of highly substituted azapolycyclic compounds via 2-alkenyl sulfoximines: potential scaffolds for peptide mimetics.
Michael Reggelin, Bernd Junker, Timo Heinrich, Stefan Slavik, Philipp Bühle

J Am Chem Soc· March 2006

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1-(1-phenethylpiperidin-4-yl)-1-phenylethanols as potent and highly selective 5-HT2A antagonists.
Timo Heinrich, Henning Böttcher, Helmut Prücher, Rudolf Gottschlich, Karl-August Ackermann

ChemMedChem· February 2006

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