Publications by authors named "Matthias Negri"

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Homology modeling meets site-directed mutagenesis: An ideal combination to elucidate the topology of 17β-HSD2.
Christoph P Sager, Susanne Weber, Matthias Negri, Pauline Banachowicz, Gabriele Möller

J Steroid Biochem Mol Biol· February 2021

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Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?
Elisabeth Weidel, Matthias Negri, Martin Empting, Stefan Hinsberger, Rolf W Hartmann

Future Med Chem· September 2015

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Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis.
Michael C Hutter, Christian Brengel, Matthias Negri, Claudia Henn, Christina Zimmer

J Mol Model· June 2014

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Discovery of novel bacterial RNA polymerase inhibitors: pharmacophore-based virtual screening and hit optimization.
Stefan Hinsberger, Kristina Hüsecken, Matthias Groh, Matthias Negri, Jörg Haupenthal

J Med Chem· November 2013

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Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking.
Elisabeth Weidel, Johannes C de Jong, Christian Brengel, Michael P Storz, Andrea Braunshausen, Matthias Negri

J Med Chem· August 2013

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Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies.
Anke Steinbach, Christine K Maurer, Elisabeth Weidel, Claudia Henn, Christian Brengel, Matthias Negri

BMC Biophys· August 2013

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Novel small molecule inhibitors targeting the "switch region" of bacterial RNAP: structure-based optimization of a virtual screening hit.
J Henning Sahner, Matthias Groh, Matthias Negri, Jörg Haupenthal, Rolf W Hartmann

Eur J Med Chem· July 2013

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Peptide-based investigation of the Escherichia coli RNA polymerase σ(70):core interface as target site.
Kristina Hüsecken, Matthias Negri, Martina Fruth, Stefan Boettcher, Rolf W Hartmann

ACS Chem Biol· April 2013

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Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11β-hydroxylase inhibition.
Silvia Gobbi, Qingzhong Hu, Matthias Negri, Christina Zimmer, Federica Belluti

J Med Chem· February 2013

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Structural optimization of 2,5-thiophene amides as highly potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.
Sandrine Marchais-Oberwinkler, Kuiying Xu, Marie Wetzel, Enrico Perspicace, Matthias Negri

J Med Chem· January 2013

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Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.
Nermin S Ahmed, Amal H Ali, Shreen M El-Nashar, Bernard D Gary, Alexandra M Fajardo, Matthias Negri

Eur J Med Chem· November 2012

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Influence of DNA template choice on transcription and inhibition of Escherichia coli RNA polymerase.
Joerg Haupenthal, Kristina Hüsecken, Matthias Negri, Christine K Maurer, Rolf W Hartmann

Antimicrob Agents Chemother· August 2012

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Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1).
Alessandro Spadaro, Matthias Negri, Sandrine Marchais-Oberwinkler, Emmanuel Bey, Martin Frotscher

PLoS One· May 2012

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Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation.
Tobias Klein, Claudia Henn, Matthias Negri, Martin Frotscher

PLoS One· February 2012

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Computational investigation of the binding mode of bis(hydroxylphenyl)arenes in 17β-HSD1: molecular dynamics simulations, MM-PBSA free energy calculations, and molecular electrostatic potential maps.
Matthias Negri, Maurizio Recanatini, Rolf W Hartmann

J Comput Aided Mol Des· September 2011

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17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.
Sandrine Marchais-Oberwinkler, Claudia Henn, Gabriele Möller, Tobias Klein, Matthias Negri

J Steroid Biochem Mol Biol· May 2011

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Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.
Simon Lucas, Matthias Negri, Ralf Heim, Christina Zimmer, Rolf W Hartmann

J Med Chem· April 2011

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Insights in 17beta-HSD1 enzyme kinetics and ligand binding by dynamic motion investigation.
Matthias Negri, Maurizio Recanatini, Rolf W Hartmann

PLoS One· August 2010

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The role of fluorine substitution in biphenyl methylene imidazole-type CYP17 inhibitors for the treatment of prostate carcinoma.
Qingzhong Hu, Matthias Negri, Sureyya Olgen, Rolf W Hartmann

ChemMedChem· June 2010

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Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.
Alexander Oster, Tobias Klein, Ruth Werth, Patricia Kruchten, Emmanuel Bey, Matthias Negri

Bioorg Med Chem· May 2010

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New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity.
Emmanuel Bey, Sandrine Marchais-Oberwinkler, Matthias Negri, Patricia Kruchten, Alexander Oster

J Med Chem· November 2009

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Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.
Ulrike E Hille, Qingzhong Hu, Carsten Vock, Matthias Negri, Marc Bartels

Eur J Med Chem· July 2009

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Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1).
Emmanuel Bey, Sandrine Marchais-Oberwinkler, Ruth Werth, Matthias Negri, Yaseen A Al-Soud

J Med Chem· November 2008

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CYP17 inhibitors. Annulations of additional rings in methylene imidazole substituted biphenyls: synthesis, biological evaluation and molecular modelling.
Mariano A E Pinto-Bazurco Mendieta, Matthias Negri, Qingzhong Hu, Ulrike E Hille, Carsten Jagusch

Arch Pharm (Weinheim)· October 2008

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Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
Simon Lucas, Ralf Heim, Matthias Negri, Iris Antes, Christina Ries

J Med Chem· October 2008

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