Publications by authors named "Emmanuel Bey"

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Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC for a proof-of-principle study.
Ahmed S Abdelsamie, Chris J van Koppen, Emmanuel Bey, Mohamed Salah, Carsten Börger

Eur J Med Chem· February 2017

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Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme.
Ahmed S Abdelsamie, Emmanuel Bey, Emanuele M Gargano, Chris J van Koppen, Martin Empting

Eur J Med Chem· October 2015

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Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker.
Ahmed S Abdelsamie, Emmanuel Bey, Nina Hanke, Martin Empting, Rolf W Hartmann

Eur J Med Chem· July 2014

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Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1).
Alessandro Spadaro, Matthias Negri, Sandrine Marchais-Oberwinkler, Emmanuel Bey, Martin Frotscher

PLoS One· May 2012

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Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.
Alexander Oster, Tobias Klein, Ruth Werth, Patricia Kruchten, Emmanuel Bey

Bioorg Med Chem· May 2010

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New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity.
Emmanuel Bey, Sandrine Marchais-Oberwinkler, Matthias Negri, Patricia Kruchten, Alexander Oster

J Med Chem· November 2009

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Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells.
Patricia Kruchten, Ruth Werth, Emmanuel Bey, Alexander Oster, Sandrine Marchais-Oberwinkler

J Steroid Biochem Mol Biol· April 2009

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The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-Hydroxysteroid Dehydrogenase (17beta-HSD) type 1 and type 2.
Yaseen A Al-Soud, Emmanuel Bey, Alexander Oster, Sandrine Marchais-Oberwinkler, Ruth Werth

Mol Cell Endocrinol· March 2009

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Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1).
Emmanuel Bey, Sandrine Marchais-Oberwinkler, Ruth Werth, Matthias Negri, Yaseen A Al-Soud

J Med Chem· November 2008

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Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics.
Sandrine Marchais-Oberwinkler, Patricia Kruchten, Martin Frotscher, Erika Ziegler, Alexander Neugebauer, Emmanuel Bey

J Med Chem· August 2008

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Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Emmanuel Bey, Sandrine Marchais-Oberwinkler, Patricia Kruchten, Martin Frotscher, Ruth Werth

Bioorg Med Chem· June 2008

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Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats.
Virginija Jazbutyte, Kai Hu, Patricia Kruchten, Emmanuel Bey, Sebastian K G Maier

Hypertension· October 2006

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