Publications by authors named "Ralf Heim"

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1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors.
Cornelia M Grombein, Qingzhong Hu, Ralf Heim, Sabrina Rau, Christina Zimmer

Eur J Med Chem· January 2015

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Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.
Simon Lucas, Matthias Negri, Ralf Heim, Christina Zimmer, Rolf W Hartmann

J Med Chem· April 2011

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Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor.
Maria Elena Silva, Ralf Heim, Andrea Strasser, Sigurd Elz, Stefan Dove

J Comput Aided Mol Des· January 2011

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Selective aldosterone synthase inhibitors reduce aldosterone formation in vitro and in vivo.
Christina Ries, Simon Lucas, Ralf Heim, Barbara Birk, Rolf W Hartmann

J Steroid Biochem Mol Biol· September 2009

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In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Simon Lucas, Ralf Heim, Christina Ries, Katarzyna E Schewe, Barbara Birk

J Med Chem· December 2008

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Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
Simon Lucas, Ralf Heim, Matthias Negri, Iris Antes, Christina Ries

J Med Chem· October 2008

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Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
Ralf Heim, Simon Lucas, Cornelia M Grombein, Christina Ries, Katarzyna E Schewe

J Med Chem· August 2008

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Expedient construction of the vibsanin E core without the use of protecting groups.
Ralf Heim, Stefan Wiedemann, Craig M Williams, Paul V Bernhardt

Org Lett· March 2005

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Unprecedented photochemical induced cascading rearrangement of the 3-azabicyclo[3.3.1]nonane skeleton.
Craig M Williams, Ralf Heim, Douglas J Brecknell, Paul V Bernhardt

Org Biomol Chem· March 2004

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