Publications by authors named "Ross A D Bathgate"

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From Structure to Function: Development of Relaxin-3 Analogs and their Role in RXFP3 Signaling.
Isabelle Riches, Hongkang Wu, Predrag Kalaba, Ashish Sethi, Tim Lkhagvajargal, Ross A D Bathgate

Chembiochem· November 2025

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Design and Synthesis of a Structurally Stabilized B‑Chain Antagonist Targeting Relaxin Family Peptide Receptor 3 (RXFP3).
Hongkang Wu, Praveen Praveen, Isabelle Riches, Devika P Suresh, Isis Gil-Miravet, Ross A D Bathgate

ACS Med Chem Lett· November 2025

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In vivo induction of crown-of-thorns starfish (Acanthaster spp.) spawning using a synthetic relaxin-like gonad-stimulating peptide.
Adam K Hillberg, Richard J Harris, Cherie A Motti, Abigail Elizur, Hongkang Wu, Ross A D Bathgate

Gen Comp Endocrinol· October 2025

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Receptor deorphanization in starfish reveals the evolution of relaxin signaling as a regulator of reproduction.
Yuling Feng, Nayeli Escudero Castelán, Mohammed Akhter Hossain, Hongkang Wu, Hidekazu Katayama, Ross A D Bathgate

BMC Biol· February 2025

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Engineering of Novel Analogues That Are More Receptor-Selective and Potent than the Native Hormone, Insulin-like Peptide 5 (INSL5).
Hongkang Wu, Herodion A Hartono, Thomas N G Handley, Bradley L Hoare, K Johan Rosengren, Ross A D Bathgate

J Med Chem· December 2024

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Biallelic RXFP2 variants lead to congenital bilateral cryptorchidism and male infertility, supporting a role of RXFP2 in spermatogenesis.
Hannes Syryn, Julie Van de Velde, Griet De Clercq, Hannah Verdin, Annelies Dheedene, Ross A D Bathgate

Hum Reprod· October 2024

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Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology.
Irina U Agoulnik, Elena M Kaftanovskaya, Courtney Myhr, Ross A D Bathgate, Martina Kocan

Biochem Pharmacol· September 2024

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Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex.
Mónica Navarro-Sánchez, Isis Gil-Miravet, Daniel Montero-Caballero, Ross A D Bathgate, Mohammed Akhter Hossain

Biochem Pharmacol· July 2024

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Total Chemical Synthesis of Aggregation-Prone Disulfide-Rich Starfish Peptides.
Hongkang Wu, Praveen Praveen, Thomas N G Handley, Chaitra Chandrashekar, Scott F Cummins, Ross A D Bathgate

Chemistry· June 2024

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Development of a synthetic relaxin-3/INSL5 chimeric peptide ligand for NanoBiT complementation binding assays.
Hongkang Wu, Bradley L Hoare, Thomas N G Handley, Mohammed Akhter Hossain, Ross A D Bathgate

Biochem Pharmacol· June 2024

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Developing insulin-like peptide 5-based antagonists for the G protein-coupled receptor, RXFP4.
Hongkang Wu, Thomas N G Handley, Bradley L Hoare, Herodion A Hartono, Daniel J Scott, Ross A D Bathgate

Biochem Pharmacol· June 2024

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Long-Circulating Vasoactive 1,18-Octadecanedioic Acid-Terlipressin Conjugate.
Or Berger, Wonmin Choi, Caroline H Ko, Matthew P Thompson, Michael J Avram, Ross A D Bathgate

ACS Pharmacol Transl Sci· May 2024

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Identification of a Novel Subtype-Selective α-Adrenoceptor Antagonist.
Alaa Abdul-Ridha, Lazarus A de Zhang, Ashenafi Haileyesus Betrie, Mattia Deluigi, Tasneem M Vaid, Ross A D Bathgate

ACS Chem Neurosci· February 2024

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Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1.
Kazem Asadollahi, Sunnia Rajput, Lazarus Andrew de Zhang, Ching-Seng Ang, Shuai Nie, Ross A D Bathgate

Nat Commun· December 2023

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Noncovalent Peptide Stapling Using Alpha-Methyl-l-Phenylalanine for α-Helical Peptidomimetics.
Ross A D Bathgate, Praveen Praveen, Ashish Sethi, Werner I Furuya, Rishi R Dhingra

J Am Chem Soc· September 2023

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Selective transduction and photoinhibition of pre-Bötzinger complex neurons that project to the facial nucleus in rats affects nasofacial activity.
Mariana R Melo, Alexander D Wykes, Angela A Connelly, Jaspreet K Bassi, Shane D Cheung, Ross A D Bathgate

Elife· September 2023

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Molecular Profiling of VGluT1 AND VGluT2 Ventral Subiculum to Nucleus Accumbens Shell Projections.
Shubo Jin, Erin J Campbell, Chi Kin Ip, Sharon Layfield, Ross A D Bathgate

Neurochem Res· August 2023

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Further Developments towards a Minimal Potent Derivative of Human Relaxin-2.
Thomas N G Handley, Praveen Praveen, Julien Tailhades, Hongkang Wu, Ross A D Bathgate

Int J Mol Sci· August 2023

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Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.
Ann-Kristin Dicke, Jakob Albrethsen, Bradley L Hoare, Margot J Wyrwoll, Alexander S Busch, Ross A D Bathgate

Hum Reprod· July 2023

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Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314.
Fabian Bumbak, James B Bower, Skylar C Zemmer, Asuka Inoue, Miquel Pons, Ross A D Bathgate

Nat Commun· June 2023

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Development of Novel High-Affinity Antagonists for the Relaxin Family Peptide Receptor 1.
Mohammed Akhter Hossain, Praveen Praveen, Nurhayati Ahmad Noorzi, Hongkang Wu, Ian P Harrison, Ross A D Bathgate

ACS Pharmacol Transl Sci· May 2023

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The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy.
Fariha Alam, Tracey A Gaspari, Barbara K Kemp-Harper, Edward Low, Aaron Aw, Ross A D Bathgate

Biomed Pharmacother· April 2023

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Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin.
Shalinda J A Fernando, Qian Wang, Debbie L Hay, Ross A D Bathgate, Peter R Shepherd

Biosci Rep· April 2023

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A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity.
Praveen Praveen, Chao Wang, Thomas N G Handley, Hongkang Wu, Chrishan S Samuel, Ross A D Bathgate

Int J Mol Sci· April 2023

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Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).
Yan Chen, Qingtong Zhou, Jiang Wang, Youwei Xu, Yun Wang, Ross A D Bathgate

Nat Commun· January 2023

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