Publications by authors named "Rowena Cube"

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Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Thomas S Reger, M Christa Mattern, Swati P Mercer, Jeffrey M Bergman, Rowena V Cube

Bioorg Med Chem Lett· October 2014

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Pyridyl amides as potent inhibitors of T-type calcium channels.
Thomas S Reger, Zhi-Qiang Yang, Kelly-Ann S Schlegel, Youheng Shu, Christa Mattern, Rowena Cube

Bioorg Med Chem Lett· March 2011

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Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents.
Zhi-Qiang Yang, Kelly-Ann S Schlegel, Youheng Shu, Thomas S Reger, Rowena Cube

ACS Med Chem Lett· December 2010

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Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists.
Kelly-Ann S Schlegel, Zhi-Qiang Yang, Thomas S Reger, Youheng Shu, Rowena Cube

Bioorg Med Chem Lett· September 2010

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Diaryl substituted pyrazoles as potent CCR2 receptor antagonists.
Anthony B Pinkerton, Dehua Huang, Rowena V Cube, John H Hutchinson, Mary Struthers

Bioorg Med Chem Lett· February 2007

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3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2).
Rowena V Cube, Jean-Michel Vernier, John H Hutchinson, Michael F Gardner, Joyce K James

Bioorg Med Chem Lett· May 2005

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
Anthony B Pinkerton, Rowena V Cube, John H Hutchinson, Joyce K James, Michael F Gardner

Bioorg Med Chem Lett· March 2005

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.
Anthony B Pinkerton, Rowena V Cube, John H Hutchinson, Joyce K James, Michael F Gardner

Bioorg Med Chem Lett· December 2004

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones.
Anthony B Pinkerton, Rowena V Cube, John H Hutchinson, Blake A Rowe, Hervé Schaffhauser

Bioorg Med Chem Lett· November 2004

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