Publications by authors named "Mary Struthers"

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Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies.
Frank R Brennan, J Ryan Polli, Jean Sathish, Melissa Ramones, Babette Wolf, Mary Struthers

MAbs· December 2025

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TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation.
Karoliina Tuomela, Rosa V Garcia, Dominic A Boardman, Pedram Tavakoli, Maria Ancheta-Schmit, Mary Struthers

Cell Rep Med· September 2025

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Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus.
Jenny H Xie, Yifan Zhang, Martine Loubeau, Paul Mangan, Elizabeth Heimrich, Mary Struthers

J Immunol· July 2021

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Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms.
Natasha C Ward, Jen Bon Lui, Rosmely Hernandez, Liping Yu, Mary Struthers

Diabetes· November 2020

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IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells.
Natasha C Ward, Aixin Yu, Alejandro Moro, Yuguang Ban, Xi Chen, Mary Struthers

J Immunol· November 2018

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A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines.
Qihong Zhao, Taeg Kim, Jian Pang, Wendy Sun, Xiaoxia Yang, Mary Struthers

J Leukoc Biol· November 2017

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Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
Scott B Hoyt, Jerry Taylor, Clare London, Amjad Ali, Feroze Ujjainwalla, Mary Struthers

Bioorg Med Chem Lett· June 2017

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Investigation of piperazine benzamides as human β adrenergic receptor agonists for the treatment of overactive bladder.
Bart H Harper, Liping Wang, Cheng Zhu, Nam F Kar, Bing Li, Mary Struthers

Bioorg Med Chem Lett· February 2017

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Imidazopyridyl compounds as aldosterone synthase inhibitors.
Brent R Whitehead, Michael M-C Lo, Amjad Ali, Min K Park, Scott B Hoyt, Mary Struthers

Bioorg Med Chem Lett· January 2017

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Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.
Whitney L Petrilli, Scott B Hoyt, Clare London, Daniel McMasters, Andreas Verras, Mary Struthers

ACS Med Chem Lett· January 2017

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Rhesus monkey model for concurrent analyses of in vivo selectivity, pharmacokinetics and pharmacodynamics of aldosterone synthase inhibitors.
Tian-Quan Cai, Sloan Stribling, Xinchun Tong, Ling Xu, Thomas Wisniewski, Mary Struthers

J Pharmacol Toxicol Methods· April 2016

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Discovery of benzamides as potent human β3 adrenergic receptor agonists.
Cheng Zhu, Nam F Kar, Bing Li, Melissa Costa, Karen H Dingley, Mary Struthers

Bioorg Med Chem Lett· January 2016

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Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.
Scott D Edmondson, Cheng Zhu, Nam Fung Kar, Jerry Di Salvo, Hiroshi Nagabukuro, Mary Struthers

J Med Chem· January 2016

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Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.
Paul R Mangan, Linhui Julie Su, Victoria Jenny, Andrea L Tatum, Caryn Picarillo, Mary Struthers

J Pharmacol Exp Ther· August 2015

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Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
Scott B Hoyt, Whitney Petrilli, Clare London, Gui-Bai Liang, Jim Tata, Mary Struthers

ACS Med Chem Lett· August 2015

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Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
Scott B Hoyt, Min K Park, Clare London, Yusheng Xiong, Jim Tata, Mary Struthers

ACS Med Chem Lett· May 2015

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Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder.
Christopher R Moyes, Richard Berger, Stephen D Goble, Bart Harper, Dong-Ming Shen, Mary Struthers

J Med Chem· February 2014

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Synthesis and immunological activities of novel Toll-like receptor 7 and 8 agonists.
Ekambar R Kandimalla, Mary Struthers, Andrew J Bett, Thomas Wisniewski, Sheri A Dubey

Cell Immunol· October 2011

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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists.
Gregori J Morriello, Harvey R Wendt, Alka Bansal, Jerry Di Salvo, Scott Feighner, Mary Struthers

Bioorg Med Chem Lett· March 2011

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CCR2 antagonists.
Mary Struthers, Alexander Pasternak

Curr Top Med Chem· January 2011

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Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation.
Maya R Jerath, Peng Liu, Mary Struthers, Julie A Demartino, Roche Peng

Thromb J· September 2010

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Synthesis and immunological activities of novel agonists of toll-like receptor 9.
Mary Struthers, Andrew J Bett, Thomas Wisniewski, Sheri A Dubey, Melissa Precopio

Cell Immunol· August 2010

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Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.
Stephen D Goble, Liping Wang, K Lulu Howell, Alka Bansal, Richard Berger, Mary Struthers

Bioorg Med Chem Lett· March 2010

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Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.
Shankaran Kothandaraman, Karla L Donnely, Gabor Butora, Richard Jiao, Alexander Pasternak, Mary Struthers

Bioorg Med Chem Lett· March 2009

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Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists.
Alexander Pasternak, Stephen D Goble, George A Doss, Nancy N Tsou, Gabor Butora, Mary Struthers

Bioorg Med Chem Lett· February 2008

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