Publications by authors named "Ruolin Cao"

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Discovery of selective ROCK2 inhibitors with free radical scavenging ability for the treatment of gouty arthritis.
Ruolin Cao, Chuqiao Song, Zhe Wang, Bingqing Lv, Wei Xiao

Mol Divers· October 2025

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Design and synthesis of Prostanoid EP4 receptor antagonists for treatment of inflammatory pain.
Huashen Xu, Min Han, Ruiyi Ma, Junning Zhuang, Xinyue Dong, Ruolin Cao

Bioorg Chem· October 2025

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Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease.
Huashen Xu, Ruolin Cao, Xinyue Dong, Ruiyi Ma, Christophe Morisseau

J Med Chem· July 2025

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Structure-Based Design and Optimization Lead to the Identification of a Novel Potent sEH Inhibitor with PPARγ Partial Agonist Activity against Inflammatory and Metabolic-Related Diseases.
Ruolin Cao, Maoying Zhang, Minggang Qi, Zhen Zhang, Christophe Morisseau

J Med Chem· April 2025

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OAB-14 Attenuated Glymphatic System Disorder, Neuroinflammation and Dyskinesia in Parkinson's Disease Model Mice Induced by Rotenone.
Xinyu Zhao, Ruolin Cao, Xiaoyi Tian, Peng Liu, Danyang Liu

Neurochem Res· April 2025

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OAB-14 alleviates mitochondrial impairment through the SIRT3-dependent mechanism in APP/PS1 transgenic mice and N2a/APP cells.
Na Zheng, Ruo-Lin Cao, Dan-Yang Liu, Peng Liu, Xin-Yu Zhao

Free Radic Biol Med· February 2025

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Recent Advances in enhancer of zeste homolog 2 Inhibitors: Structural insights and therapeutic applications.
Ruolin Cao, Jiayang Ni, Xiaoyu Zhang, Minggang Qi, Zhen Zhang

Bioorg Chem· January 2025

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The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif.
Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi

RSC Med Chem· August 2024

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2,2- dimethylbenzopyran derivatives containing pyridone structural fragments as selective dual-targeting inhibitors of HIF-1α and EZH2 for the treatment of lung cancer.
Huashen Xu, Jie Zhang, Junning Zhuang, Yuanguang Chen, Lu Chen, Ruolin Cao

Bioorg Chem· June 2024

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Synthesis and biological evaluations of 8-biaryl-2,2-dimethylbenzopyranamide derivatives against Alzheimer's disease and ischemic stroke.
Ruolin Cao, Fangyu Du, Yuhang Cui, Minggang Qi, Junning Zhuang

Bioorg Chem· February 2024

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Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality.
Yuanguang Chen, Jianwen Sun, Hua Tong, Jieru Wang, Ruolin Cao

J Med Chem· February 2024

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The bexarotene derivative OAB-14 ameliorates cognitive decline in APP/PS1 transgenic mice by suppressing microglia-mediated neuroinflammation through the PPAR-γ pathway.
Feng Zhang, Ruo-Lin Cao, Peng Liu, Tian-Yan Chi, Xue-Fei Ji

Int Immunopharmacol· November 2023

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Mechanism of anti-AD action of OAB-14 by enhancing the function of glymphatic system.
Xian Zhang, Ruolin Cao, Chao Zhu, Luxi Yang, Na Zheng

Neurochem Int· October 2023

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Structure-Directed Discovery of Potent Soluble Epoxide Hydrolase Inhibitors for the Treatment of Inflammatory Diseases.
Yuanguang Chen, Lu Chen, Huashen Xu, Ruolin Cao, Christophe Morisseau

J Med Chem· February 2023

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Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain.
Fangyu Du, Ruolin Cao, Lu Chen, Jianwen Sun, Yajie Shi

Acta Pharm Sin B· March 2022

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Enhanced remediation of Cr(VI)-contaminated groundwater by coupling electrokinetics with ZVI/FeO/AC-based permeable reactive barrier.
Ruolin Cao, Shiqing Liu, Xinyu Yang, Chunfeng Wang, Yanbin Wang

J Environ Sci (China)· February 2022

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