Publications by authors named "Yuanguang Chen"

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Ligand-based design and optimization of tecovirimat derivatives as potent antiviral agents against monkeypox virus.
Yuanguang Chen, Sumei Yang, Xingyu Zhou, Hongyang Yi, Dizhen Liang

Eur J Med Chem· February 2026

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Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative.
Yuanguang Chen, Yongqing Liu, Guanguan Li, Chao Peng, Dizhen Liang

Acta Pharm Sin B· December 2025

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Mini review: SHEN26, a novel oral antiviral drug for COVID-19 treatment.
Peisen Zheng, Guanguan Li, Yuanguang Chen, Shuo Li, Sidi Yang

Bioorg Med Chem Lett· August 2025

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Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease.
Huashen Xu, Ruolin Cao, Xinyue Dong, Ruiyi Ma, Christophe Morisseau, Yuanguang Chen, Lu Chen, Guoliang Chen

J Med Chem· July 2025

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Design and Synthesis of sEH/HDAC6 Dual-Targeting Inhibitors for the Treatment of Inflammatory Pain.
Huashen Xu, Yuanguang Chen, Hua Tong, Lu Chen, Christophe Morisseau, Pengcheng Cai, Guoliang Chen

J Med Chem· August 2024

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2,2- dimethylbenzopyran derivatives containing pyridone structural fragments as selective dual-targeting inhibitors of HIF-1α and EZH2 for the treatment of lung cancer.
Huashen Xu, Jie Zhang, Junning Zhuang, Yuanguang Chen, Lu Chen, Guoliang Chen

Bioorg Chem· June 2024

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Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality.
Yuanguang Chen, Jianwen Sun, Hua Tong, Jieru Wang, Ruolin Cao, Lu Chen, Guoliang Chen

J Med Chem· February 2024

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Design, synthesis and evaluation of the novel chalcone derivatives with 2,2-dimethylbenzopyran as HIF-1 inhibitors that possess anti-angiogenic potential.
Huashen Xu, Jianmin Wang, Yuanguang Chen, Yang Du, Lu Chen, Guoliang Chen

Eur J Med Chem· March 2023

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Structure-Directed Discovery of Potent Soluble Epoxide Hydrolase Inhibitors for the Treatment of Inflammatory Diseases.
Yuanguang Chen, Lu Chen, Huashen Xu, Ruolin Cao, Christophe Morisseau, Guoliang Chen

J Med Chem· February 2023

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Multicenter investigation of bowel evacuation function after transanal total mesorectal excision for mid-low rectal cancer.
Zhanlong Shen, Gang Yu, Mingyang Ren, Chao Ding, Hongyu Zhang, Yuanguang Chen

Int J Colorectal Dis· April 2021

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Transanal vs laparoscopic total mesorectal excision for rectal cancer: a multicenter randomized phase III clinical trial (TaLaR trial) protocol.
Liang Kang, Ziwei Zeng, Shuangling Luo, Hong Zhang, Quan Wang, Yuan-Guang Chen

Gastroenterol Rep (Oxf)· January 2021

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Transanal total mesorectal excision for rectal cancer: a multicentric cohort study.
Liang Kang, Yuan-Guang Chen, Hao Zhang, Hong-Yu Zhang, Guo-Le Lin, Wen-Hao Chen, Ning Chen

Gastroenterol Rep (Oxf)· February 2020

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l -( -) -Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles.
Qifan Zhou, Fangyu Du, Yuanguang Chen, Yang Fu, Wenjiao Sun, Guoliang Chen

J Org Chem· June 2019

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[Long-term efficacy of laparoscope-assisted transanal total mesorectal excision for rectal cancer].
Dachao Zhang, Yuanguang Chen, Ming Hu, Jiongqiang Huang, Tongyi Xia, Jinsong Chen

Zhonghua Wei Chang Wai Ke Za Zhi· March 2019

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Synthesis and biological evaluation of 2,2-dimethylbenzopyran derivatives as potent neuroprotection agents.
Fangyu Du, Qifan Zhou, Xiaoxiao Fu, Yajie Shi, Yuanguang Chen, Guoliang Chen

RSC Adv· January 2019

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Mangiferin prevents the growth of gastric carcinoma by blocking the PI3K-Akt signalling pathway.
Min Du, Gang Wen, Juan Jin, Yuanguang Chen, Jun Cao

Anticancer Drugs· February 2018

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Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis.
Chenggang Li, Na Li, Xiaolei Liu, Erik Y Zhang, Yang Sun, Yuanguang Chen

JCI Insight· November 2016

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