Publications by authors named "Russell Dushin"

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Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia.
Yoon-Chi Han, Jennifer Kahler, Nicole Piché-Nicholas, Wenyue Hu, Stephane Thibault, Russell Dushin

Clin Cancer Res· January 2021

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Cycloisomerization of Olefins in Water.
Jeishla L M Matos, Samantha A Green, Yuge Chun, Vuong Q Dang, Russell G Dushin

Angew Chem Int Ed Engl· July 2020

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Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma.
Siler H Panowski, Tracy C Kuo, Yi Zhang, Amy Chen, Tao Geng, Russell G Dushin

Mol Cancer Ther· November 2019

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Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.
Dahui Zhou, Jeffrey Casavant, Edmund I Graziani, Haiyin He, Jeffrey Janso, Russell Dushin

Bioorg Med Chem Lett· April 2019

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Kinetically guided radical-based synthesis of C(sp)-C(sp) linkages on DNA.
Jie Wang, Helena Lundberg, Shota Asai, Pedro Martín-Acosta, Jason S Chen, Russell G Dushin

Proc Natl Acad Sci U S A· July 2018

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Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1).
Matthew Sung, Xingzhi Tan, Bingwen Lu, Jonathan Golas, Christine Hosselet, Russell Dushin

Mol Cancer Ther· January 2018

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Improved Lysosomal Trafficking Can Modulate the Potency of Antibody Drug Conjugates.
Rachel M DeVay, Kathy Delaria, Guoyun Zhu, Charles Holz, Davide Foletti, Russell Dushin

Bioconjug Chem· April 2017

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A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions.
Marc Damelin, Alexander Bankovich, Jeffrey Bernstein, Justin Lucas, Liang Chen, Russell Dushin

Sci Transl Med· January 2017

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RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models.
Pavel Strop, Thomas-Toan Tran, Magdalena Dorywalska, Kathy Delaria, Russell Dushin

Mol Cancer Ther· November 2016

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Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.
Magdalena Dorywalska, Russell Dushin, Ludivine Moine, Santiago E Farias, Dahui Zhou

Mol Cancer Ther· May 2016

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Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy.
Magdalena Dorywalska, Pavel Strop, Jody A Melton-Witt, Adela Hasa-Moreno, Santiago E Farias, Russell Dushin

PLoS One· April 2016

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Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading.
Pavel Strop, Kathy Delaria, Davide Foletti, Jody Melton Witt, Adela Hasa-Moreno, Russell Dushin

Nat Biotechnol· July 2015

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Effect of attachment site on stability of cleavable antibody drug conjugates.
Magdalena Dorywalska, Pavel Strop, Jody A Melton-Witt, Adela Hasa-Moreno, Santiago E Farias, Russell Dushin

Bioconjug Chem· April 2015

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One-pot oxidation and rearrangement of propargylamines and in situ pyrazole synthesis.
Jinshan Chen, Roberta Properzi, Daniel P Uccello, Jennifer A Young, Russell G Dushin

Org Lett· August 2014

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A general approach to site-specific antibody drug conjugates.
Feng Tian, Yingchun Lu, Anthony Manibusan, Aaron Sellers, Hon Tran, Russell Dushin

Proc Natl Acad Sci U S A· February 2014

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Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.
Pavel Strop, Shu-Hui Liu, Magdalena Dorywalska, Kathy Delaria, Russell G Dushin

Chem Biol· February 2013

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Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells.
Puja Sapra, Marc Damelin, John Dijoseph, Kimberly Marquette, Kenneth G Geles, Russell Dushin

Mol Cancer Ther· January 2013

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Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.
Christoph W Zapf, Jonathan D Bloom, Zhong Li, Russell G Dushin, Thomas Nittoli

Bioorg Med Chem Lett· August 2011

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Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
Christoph W Zapf, Jonathan D Bloom, Jamie L McBean, Russell G Dushin, Thomas Nittoli

Bioorg Med Chem Lett· June 2011

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Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
Christoph W Zapf, Jonathan D Bloom, Jamie L McBean, Russell G Dushin, Jennifer M Golas

Bioorg Med Chem Lett· June 2011

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Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.
Christoph W Zapf, Jonathan D Bloom, Jamie L McBean, Russell G Dushin, Thomas Nittoli

Bioorg Med Chem Lett· April 2011

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The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1).
Thomas Nittoli, Russell G Dushin, Charles Ingalls, Katherine Cheung, M Brawner Floyd

Eur J Med Chem· April 2010

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Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.
Kyung-Hee Kim, Allan Wissner, Middleton B Floyd, Heidi L Fraser, Yanong D Wang, Russell G Dushin

Bioorg Med Chem Lett· September 2009

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Synthesis and PKCtheta inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles.
Russell G Dushin, Thomas Nittoli, Charles Ingalls, Diane H Boschelli, Derek C Cole

Bioorg Med Chem Lett· May 2009

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Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2.
Allan Wissner, Heidi L Fraser, Charles L Ingalls, Russell G Dushin, M Brawner Floyd

Bioorg Med Chem· June 2007

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