Publications by authors named "Ruth Steele"

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A Novel Small Molecule Allosteric Inhibitor of IL-17A from a DNA-Encoded Library.
Marcos E Milla, Jonathan M Blevitt, Steven D Goldberg, Anthony A Armstrong, Katherine Y Blain, Ruth A Steele

ACS Med Chem Lett· November 2025

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Folding-mediated secretion of pure bispecific antibodies.
Cholpon Tilegenova, Tun Liu, Qian Zhao, Mahati Are, Yu Zhao, Ruth Steele

Nat Biotechnol· October 2025

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Author Correction: Folding-mediated secretion of pure bispecific antibodies.
Cholpon Tilegenova, Tun Liu, Qian Zhao, Mahati Are, Yu Zhao, Ruth Steele

Nat Biotechnol· October 2025

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Guselkumab binding to CD64 IL-23-producing myeloid cells enhances potency for neutralizing IL-23 signaling.
Kacey L Sachen, Deepa Hammaker, Indra Sarabia, Brian Stoveken, John Hartman, Ruth Steele

Front Immunol· May 2025

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Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration.
François P Bischoff, Sven Van Brandt, Marcel Viellevoye, Michel De Cleyn, Michel Surkyn, Ruth A Steele

J Med Chem· February 2025

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Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias.
Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Ruth Steele

Blood· September 2024

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JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans.
Anne M Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Ruth Steele

Sci Rep· July 2024

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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Holger Babbe, Thomas B Sundberg, Mark Tichenor, Mark Seierstad, Genesis Bacani, Ruth Steele

Proc Natl Acad Sci U S A· January 2024

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Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Rosalie E Matico, Xiaodi Yu, Robyn Miller, Sandeep Somani, M Daniel Ricketts, Ruth A Steele

Nat Struct Mol Biol· January 2024

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Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer.
Tsehai A J Grell, Mark Mason, Aaron A Thompson, Jose Carlos Gómez-Tamayo, Daniel Riley, Ruth Steele

Heliyon· December 2022

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Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
Guozhang Xu, Zhijie Liu, Xinkang Wang, Tianbao Lu, Renee L DesJarlais, Ruth A Steele

J Med Chem· August 2022

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Identification of Two Non-Peptidergic Small Molecule Inhibitors of CBX2 Binding to K27 Trimethylated Oligonucleosomes.
Lukas Lercher, Nina Simon, Andreas Bergmann, Marcel Tauchert, David Bochmann, Ruth Steele

SLAS Discov· July 2022

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Inhibitor Bound Dengue NS2B-NS3pro Reveals Multiple Dynamic Binding Modes.
Alan C Gibbs, Ruth Steele, Gaohua Liu, Brett A Tounge, Gaetano T Montelione

Biochemistry· March 2018

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Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

N Engl J Med· June 2015

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Family history of cancer in benign brain tumor subtypes versus gliomas.
Quinn T Ostrom, Christopher McCulloh, Yanwen Chen, Karen Devine, Yingli Wolinsky, Ruth Steele

Front Oncol· August 2012

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