Publications by authors named "Ryan D Roberts"

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Metastasis-Initiating Osteosarcoma Subpopulations Establish Paracrine Interactions with Lung and Tumor Cells to Create a Metastatic Niche.
James B Reinecke, Leyre Jimenez Garcia, Amanda J Saraf, John Hinckley, Amy C Gross, Ryan D Roberts

Cancer Res· November 2025

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Local Control and Toxicity Outcomes After Stereotactic Body Radiation Therapy for Metastatic Osteosarcoma in Pediatric Patients.
Sohil Reddy, Rituraj Upadhyay, Brett Klamer, Raj Singh, David Konieczkowski, Ryan D Roberts

Pediatr Blood Cancer· September 2025

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MyoD is essential in rhabdomyosarcoma by promoting survival through differentiation and CYLD.
Alexander R Oles, Peter Y Yu, Abasi-Ama Udeme, Sudarshana Sharma, Priya Londhe, Ryan D Roberts

iScience· August 2025

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ReNeu: A Pivotal, Phase IIb Trial of Mirdametinib in Adults and Children With Symptomatic Neurofibromatosis Type 1-Associated Plexiform Neurofibroma.
Christopher L Moertel, Angela C Hirbe, Hans H Shuhaiber, Kevin Bielamowicz, Alpa Sidhu, Ryan D Roberts

J Clin Oncol· February 2025

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Aberrant Activation of Wound-Healing Programs within the Metastatic Niche Facilitates Lung Colonization by Osteosarcoma Cells.
James B Reinecke, Leyre Jimenez Garcia, Amy C Gross, Maren Cam, Matthew V Cannon, Ryan D Roberts

Clin Cancer Res· January 2025

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Trabectedin promotes oncolytic virus antitumor efficacy, viral gene expression, and immune effector function in models of bone sarcoma.
Emily M Ringwalt, Mark A Currier, Andrea M Glaspell, Chun-Yu Chen, Matthew V Cannon, Ryan D Roberts

Mol Ther Oncol· December 2024

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Employing splice-switching oligonucleotides and AAVrh74.U7 snRNA to target insulin receptor splicing and cancer hallmarks in osteosarcoma.
Safiya Khurshid, Akila S Venkataramany, Matias Montes, John F Kipp, Ryan D Roberts

Mol Ther Oncol· December 2024

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Optimizing Ewing Sarcoma and Osteosarcoma Biopsy Acquisition: A Children's Oncology Group Bone Tumor Committee Consensus Statement.
Matthew S Dietz, Alyaa Al-Ibraheemi, Jessica L Davis, C Matthew Hawkins, Brian T Craig, Ryan D Roberts

J Natl Compr Canc Netw· December 2024

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Treatment with novel topoisomerase inhibitors in Ewing sarcoma models reveals heterogeneity of tumor response.
Unsun Lee, Ludmila Szabova, Victor J Collins, Melanie Gordon, Kristine Johnson, Ryan D Roberts

Front Cell Dev Biol· October 2024

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Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells.
James B Reinecke, Leyre Jimenez Garcia, Amy C Gross, Maren Cam, Matthew V Cannon, Ryan D Roberts

bioRxiv· September 2024

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Disease Control and Toxicity Outcomes after Stereotactic Ablative Radiation Therapy for Recurrent and/or Metastatic Cancers in Young-Adult and Pediatric Patients.
Rituraj Upadhyay, Brett Klamer, Jennifer Matsui, Vikram B Chakravarthy, Thomas Scharschmidt, Ryan D Roberts

Cancers (Basel)· May 2024

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Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma.
Emily M Ringwalt, Mark A Currier, Andrea M Glaspell, Chun-Yu Chen, Matthew V Cannon, Ryan D Roberts

bioRxiv· March 2024

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Progress in sarcomas: Highlights from the 2023 annual meetingof the Connective Tissue Oncology Society.
Timothy P Cripe, Ryan D Roberts, Dawn S Chandler, Bhuvana A Setty, Sonja Chen

Mol Ther Oncol· March 2024

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Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.
Camille A McAloney, Rawan Makkawi, Yogesh Budhathoki, Matthew V Cannon, Emily M Franz, Ryan D Roberts

Cell Oncol (Dordr)· February 2024

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Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy.
Katherine E Miller, Adithe C Rivaldi, Noriyuki Shinagawa, Sahib Sran, Jason B Navarro, Ryan D Roberts

Nat Genet· November 2023

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Osteosarcoma Multi-Omics Landscape and Subtypes.
Shan Tang, Ryan D Roberts, Lijun Cheng, Lang Li

Cancers (Basel)· October 2023

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Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution.
Jack Hedberg, Adam Studebaker, Luke Smith, Chun-Yu Chen, Jesse J Westfall, Ryan D Roberts

Mol Ther Oncolytics· September 2023

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Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma.
Terry J Shackleford, Seethalakshmi Hariharan, Angelina V Vaseva, Karina Alagoa, Maricruz Espinoza, Ryan D Roberts

Mol Cancer Ther· April 2023

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Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time.
Sanjana Rajan, Simone Zaccaria, Matthew V Cannon, Maren Cam, Amy C Gross, Ryan D Roberts

Cancer Res Commun· April 2023

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Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization.
Sanjana Rajan, Emily M Franz, Camille A McAloney, Tatyana A Vetter, Maren Cam, Ryan D Roberts

BMC Biol· April 2023

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Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma.
Sakthi Rajendran, Yang Hu, Alessandro Canella, Clayton Peterson, Amy Gross, Ryan D Roberts

Cell Rep· March 2023

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Osteosarcoma.
Hannah C Beird, Stefan S Bielack, Adrienne M Flanagan, Jonathan Gill, Dominique Heymann, Ryan D Roberts

Nat Rev Dis Primers· December 2022

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Author Correction: Osteosarcoma.
Hannah C Beird, Stefan S Bielack, Adrienne M Flanagan, Jonathan Gill, Dominique Heymann, Ryan D Roberts

Nat Rev Dis Primers· December 2022

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An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma.
David S Shulman, Sarah B Whittle, Didier Surdez, Kelly M Bailey, Enrique de Álava, Ryan D Roberts

NPJ Precis Oncol· September 2022

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Lurbinectedin Inhibits the EWS-WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor.
Jenna M Gedminas, Rebecca Kaufman, Elissa A Boguslawski, Amy C Gross, Marie Adams, Ryan D Roberts

Mol Cancer Ther· August 2022

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