Publications by authors named "Ryan Gumpper"

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Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors.
Michael Bram Kuijer, Camryn J Fulton, Talia L Albert, Paloma Knobloch, Jing Wang, Ryan H Gumpper

Biochemistry· December 2025

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The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
Manish K Jain, Ryan H Gumpper, Samuel T Slocum, Gavin P Schmitz, Jakob S Madsen

Neuron· October 2025

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Differential effects of sodium on agonist-induced conformational transitions and signaling at μ and κ opioid receptors.
Bram Kuijer, Camryn J Fulton, Talia L Albert, Paloma M Knobloch, Jing Wang, Ryan H Gumpper

bioRxiv· September 2025

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The structural diversity of psychedelic drug actions revealed.
Ryan H Gumpper, Manish K Jain, Kuglae Kim, Renhong Sun, Ning Sun

Nat Commun· March 2025

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Molecular Glues: A New Approach to Modulating GPCR Signaling Bias.
Jamie Kushnir, Ryan H Gumpper

Biochemistry· February 2025

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High-affinity agonists reveal recognition motifs for the MRGPRD GPCR.
Chunyu Wang, Yongfeng Liu, Marion Lanier, Adam Yeager, Isha Singh, Ryan H Gumpper

Cell Rep· December 2024

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Structure-guided design of a peripherally restricted chemogenetic system.
Hye Jin Kang, Brian E Krumm, Adrien Tassou, Matan Geron, Jeffrey F DiBerto, Ryan H Gumpper

Cell· December 2024

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Chemistry/structural biology of psychedelic drugs and their receptor(s).
Ryan H Gumpper, David E Nichols

Br J Pharmacol· October 2024

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AlphaFold2 structures guide prospective ligand discovery.
Jiankun Lyu, Nicholas Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang

Science· June 2024

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Author Correction: Bitter taste receptor activation by cholesterol and an intracellular tastant.
Yoojoong Kim, Ryan H Gumpper, Yongfeng Liu, D Dewran Kocak, Yan Xiong

Nature· June 2024

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Bitter taste receptor activation by cholesterol and an intracellular tastant.
Yoojoong Kim, Ryan H Gumpper, Yongfeng Liu, D Dewran Kocak, Yan Xiong

Nature· April 2024

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AlphaFold2 structures template ligand discovery.
Jiankun Lyu, Nicholas Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang

bioRxiv· March 2024

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Psychedelics: preclinical insights provide directions for future research.
Ryan H Gumpper, Bryan L Roth

Neuropsychopharmacology· January 2024

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DNA selection by the master transcription factor PU.1.
J Ross Terrell, Samuel J Taylor, Amelia L Schneider, Yue Lu, Tyler N Vernon, Ryan H Gumpper

Cell Rep· July 2023

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Psychedelics as Transformative Therapeutics.
Bryan L Roth, Ryan H Gumpper

Am J Psychiatry· May 2023

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Ligand recognition and allosteric modulation of the human MRGPRX1 receptor.
Yongfeng Liu, Can Cao, Xi-Ping Huang, Ryan H Gumpper, Moira M Rachman

Nat Chem Biol· April 2023

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SnapShot: Psychedelics and serotonin receptor signaling.
Ryan H Gumpper, Bryan L Roth

Cell· January 2023

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Molecular basis for selective activation of DREADD-based chemogenetics.
Shicheng Zhang, Ryan H Gumpper, Xi-Ping Huang, Yongfeng Liu, Brian E Krumm

Nature· December 2022

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Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.
Can Cao, Ximena Barros-Álvarez, Shicheng Zhang, Kuglae Kim, Marc A Dämgen, Ryan H Gumpper

Neuron· October 2022

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Molecular insights into the regulation of constitutive activity by RNA editing of 5HT serotonin receptors.
Ryan H Gumpper, Jonathan F Fay, Bryan L Roth

Cell Rep· August 2022

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Structure, function and pharmacology of human itch GPCRs.
Can Cao, Hye Jin Kang, Isha Singh, He Chen, Chengwei Zhang, Ryan H Gumpper

Nature· December 2021

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G-Protein Peptidomimetics Stabilize GPCR Active State Conformations.
Ryan H Gumpper, Bryan L Roth

Trends Pharmacol Sci· June 2021

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Constraints of Viral RNA Synthesis on Codon Usage of Negative-Strand RNA Virus.
Ryan H Gumpper, Weike Li, Ming Luo

J Virol· March 2019

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Complementary Mutations in the N and L Proteins for Restoration of Viral RNA Synthesis.
Weike Li, Ryan H Gumpper, Yusuf Uddin, Ingeborg Schmidt-Krey, Ming Luo

J Virol· November 2018

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High-resolution structure of the Influenza A virus PB2cap binding domain illuminates the changes induced by ligand binding.
Amanda Constantinides, Ryan Gumpper, Chelsea Severin, Ming Luo

Acta Crystallogr F Struct Biol Commun· March 2018

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