Publications by authors named "Ryan Keddy"

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Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).
Rolf Wagner, John T Randolph, Sachin V Patel, Lissa Nelson, Mark A Matulenko, Ryan Keddy

J Med Chem· May 2018

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Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.
David A DeGoey, John T Randolph, Dachun Liu, John Pratt, Charles Hutchins, Ryan Keddy

J Med Chem· March 2014

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Discovery of TRPV1 antagonist ABT-116.
Brian S Brown, Ryan Keddy, Richard J Perner, Stanley DiDomenico, John R Koenig

Bioorg Med Chem Lett· June 2010

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Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Brian S Brown, Ryan Keddy, Guo Zhu Zheng, Robert G Schmidt, John R Koenig

Bioorg Med Chem· September 2008

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Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model.
Arthur Gomtsyan, Erol K Bayburt, Ryan Keddy, Sean C Turner, Tammie K Jinkerson

Bioorg Med Chem Lett· July 2007

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In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists.
Richard J Perner, Stanley DiDomenico, John R Koenig, Arthur Gomtsyan, Erol K Bayburt, Ryan G Keddy

J Med Chem· July 2007

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Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.
Irene Drizin, Arthur Gomtsyan, Erol K Bayburt, Robert G Schmidt, Guo Zhu Zheng, Ryan G Keddy

Bioorg Med Chem· July 2006

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