Publications by authors named "John Pratt"

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Characterising negative symptoms in schizophrenia: CHANSS study protocol.
Noham Wolpe, Clàudia Aymerich, Ying Jin, Marta Martin-Subero, Paloma Fuentes-Perez, John Pratt

BJPsych Open· November 2025

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Forest school INterventions for Children's Health: a feasibility cluster randomised controlled trial to compare Forest School versus usual indoor classroom-based curriculum activity with KS2 children: the FINCH protocol.
Hannah A Armitt, Rachel M Bottomley-Wise, Jodi Pervin, Sarah Blower, Sara Booth-Card, John Pratt

NIHR Open Res· October 2025

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Citizen scientists filling knowledge gaps of phosphate pollution dynamics in rural areas.
Steven Loiselle, Isabel Bishop, Heather Moorhouse, Caroline Pilat, Eline Koelman, John Pratt

Environ Monit Assess· January 2024

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Discovery of -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1-pyrrolo[2,3-]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
George S Sheppard, Le Wang, Steven D Fidanze, Lisa A Hasvold, Dachun Liu, John K Pratt

J Med Chem· May 2020

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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Emily J Faivre, Keith F McDaniel, Daniel H Albert, Srinivasa R Mantena, Joshua P Plotnik, John K Pratt

Nature· February 2020

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Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Steven D Fidanze, Dachun Liu, Robert A Mantei, Lisa A Hasvold, John K Pratt

Bioorg Med Chem Lett· June 2018

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Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).
Rolf Wagner, John T Randolph, Sachin V Patel, Lissa Nelson, Mark A Matulenko, John K Pratt

J Med Chem· May 2018

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Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.
John T Randolph, A Chris Krueger, Pamela L Donner, John K Pratt, Dachun Liu

J Med Chem· February 2018

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Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
Keith F McDaniel, Le Wang, Todd Soltwedel, Steven D Fidanze, Lisa A Hasvold, John K Pratt

J Med Chem· October 2017

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Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.
Mai H Bui, Xiaoyu Lin, Daniel H Albert, Leiming Li, Lloyd T Lam, John K Pratt

Cancer Res· June 2017

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Methylpyrrole inhibitors of BET bromodomains.
Lisa A Hasvold, George S Sheppard, Le Wang, Steven D Fidanze, Dachun Liu, John K Pratt

Bioorg Med Chem Lett· May 2017

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Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
Le Wang, John K Pratt, Todd Soltwedel, George S Sheppard, Steven D Fidanze

J Med Chem· May 2017

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Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.
David A DeGoey, John T Randolph, Dachun Liu, John Pratt, Charles Hutchins

J Med Chem· March 2014

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Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A.
David A DeGoey, David A Betebenner, David J Grampovnik, Dachun Liu, John K Pratt

Bioorg Med Chem Lett· June 2013

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Imaging of human mesenchymal stromal cells: homing to human brain tumors.
Lata G Menon, John Pratt, Hong Wei Yang, Peter M Black, Gregory A Sorensen

J Neurooncol· April 2012

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Orbital inflammation and lyme disease.
John W Pratt, Dale R Meyer, Danielle Wroblewski, J Andrew Carlson

Ophthalmology· September 2011

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Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.
Rolf Wagner, Daniel P Larson, David W A Beno, Todd D Bosse, John F Darbyshire, John K Pratt

J Med Chem· March 2009

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Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase.
Yaya Liu, Pamela L Donner, John K Pratt, Wen W Jiang, Teresa Ng

Bioorg Med Chem Lett· June 2008

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Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.
Pamela L Donner, Qinghua Xie, John K Pratt, Clarence J Maring, Warren Kati

Bioorg Med Chem Lett· April 2008

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Effects of glucose toxicity and islet purity on in vivo magnetic resonance imaging of transplanted pancreatic islets.
Natalia V Evgenov, John Pratt, Pamela Pantazopoulos, Anna Moore

Transplantation· April 2008

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The effect of chronic lorazepam administration in aging mice.
Jeanne M Fahey, Gary A Pritchard, Jyoti M Reddi, John S Pratt, Jeffrey M Grassi

Brain Res· November 2006

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In vivo imaging of immune rejection in transplanted pancreatic islets.
Natalia V Evgenov, Zdravka Medarova, John Pratt, Pamela Pantazopoulos, Simone Leyting

Diabetes· September 2006

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Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction.
Yaya Liu, Wen W Jiang, John Pratt, Todd Rockway, Kevin Harris

Biochemistry· September 2006

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Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.
A Chris Krueger, Darold L Madigan, Wen W Jiang, Warren M Kati, Dachun Liu, John K Pratt

Bioorg Med Chem Lett· July 2006

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Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.
Todd W Rockway, Rong Zhang, Dachun Liu, David A Betebenner, Keith F McDaniel, John K Pratt

Bioorg Med Chem Lett· July 2006

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