Publications by authors named "Ryan S Soderquist"

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Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis.
Shane T Killarney, Rachel Washart, Ryan S Soderquist, Jacob P Hoj, Jamie Lebhar

Nat Commun· March 2023

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Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells.
Moiez Ali, Min Lu, Hazel Xiaohui Ang, Ryan S Soderquist, Christine E Eyler

Sci Transl Med· March 2022

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Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.
Mandana T Manzari, Gray R Anderson, Kevin H Lin, Ryan S Soderquist, Merve Çakir

Sci Adv· September 2019

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Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.
Kevin H Lin, Abigail Xie, Justine C Rutter, Yeong-Ran Ahn, Julia M Lloyd-Cowden, Ryan S Soderquist

Cell Metab· May 2019

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Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477.
David J Mallick, Ryan S Soderquist, Darcy Bates, Alan Eastman

Cell Death Dis· February 2019

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Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity.
Ryan S Soderquist, Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal

Nat Commun· August 2018

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A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.
Grace R Anderson, Peter S Winter, Kevin H Lin, Daniel P Nussbaum, Merve Cakir, Ryan S Soderquist

Cell Rep· July 2017

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PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
Gray R Anderson, Suzanne E Wardell, Merve Cakir, Lorin Crawford, Jim C Leeds, Ryan S Soderquist

Sci Transl Med· December 2016

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BCL2 Inhibitors as Anticancer Drugs: A Plethora of Misleading BH3 Mimetics.
Ryan S Soderquist, Alan Eastman

Mol Cancer Ther· September 2016

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Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells.
Cody Paiva, J Claire Godbersen, Ryan S Soderquist, Taylor Rowland, Sumner Kilmarx

PLoS One· June 2016

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Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.
Ryan S Soderquist, Alexey V Danilov, Alan Eastman

J Biol Chem· June 2014

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Genetic analysis of the Replication Protein A large subunit family in Arabidopsis reveals unique and overlapping roles in DNA repair, meiosis and DNA replication.
Behailu B Aklilu, Ryan S Soderquist, Kevin M Culligan

Nucleic Acids Res· March 2014

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Toward a cure for chronic lymphocytic leukemia: an attack on multiple fronts.
Alexey V Danilov, Ryan S Soderquist, Darcy J P Bates, Alan Eastman

Expert Rev Anticancer Ther· September 2013

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Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells.
Matthew Wood, Melissa Rawe, Gunnar Johansson, Shu Pang, Ryan S Soderquist

Mol Cancer Ther· September 2011

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Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.
Tina C Albershardt, Bethany L Salerni, Ryan S Soderquist, Darcy J P Bates, Alexandre A Pletnev

J Biol Chem· July 2011

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