Publications by authors named "Ryan Watts"

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Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model.
Vanessa O Torres, Michelle E Pizzo, Darren Chan, Jason C Dugas, David Huynh, Ryan J Watts

J Cereb Blood Flow Metab· January 2026

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An Intravenous Brain-Penetrant Enzyme Therapy for Mucopolysaccharidosis II.
Joseph Muenzer, Barbara K Burton, Paul Harmatz, Deepa S Rajan, Simon A Jones, Ryan J Watts

N Engl J Med· January 2026

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Non-coding RNAs in plant stress responses: molecular insights and agricultural applications.
Xiaotong Chen, Zhaohui Chen, Ryan Watts, Hong Luo

Plant Biotechnol J· August 2025

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Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules.
Robert C Wells, Padma Akkapeddi, Darren Chan, David Joy, Arash Moshkforoush, Ryan J Watts

Cell Rep· August 2025

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Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Michelle E Pizzo, Edward D Plowey, Nathalie Khoury, Wanda Kwan, Jordan Abettan, Ryan J Watts

Science· August 2025

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Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier.
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew J Simon, Ryan J Watts

Sci Transl Med· August 2024

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Todd Logan, Matthew J Simon, Anil Rana, Gerald M Cherf, Ankita Srivastava, Ryan J Watts

Cell· March 2024

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Author Correction: CD98hc is a target for brain delivery of biotherapeutics.
Kylie S Chew, Robert C Wells, Arash Moshkforoush, Darren Chan, Kendra J Lechtenberg, Ryan J Watts

Nat Commun· September 2023

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CD98hc is a target for brain delivery of biotherapeutics.
Kylie S Chew, Robert C Wells, Arash Moshkforoush, Darren Chan, Kendra J Lechtenberg, Ryan J Watts

Nat Commun· August 2023

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Evaluating the Use of Parenteral Naloxone in the Emergency Department of a Community Hospital.
Ryan P Watts, Winifred P Pardo, Eduardo Martinez Sanchez, Anthony P Degelorm, Ada P Jalice

Hosp Pharm· April 2023

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A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Ryan J Watts

Nat Neurosci· March 2023

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Hemorrhagic Stroke Due to Varicella Zoster Virus Vasculopathy.
Reese Hofstrand, Rafael Portela, Ryan Juneau, Chika Okafor, Ryan Watts

Cureus· March 2023

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Postpartum Idiopathic Pancreatitis Complicated by Acute Necrotizing Pancreatitis.
Reese Hofstrand, Mayank Singhal, Jagroop Doad, Ryan Watts

Cureus· January 2023

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Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
Annie Arguello, Cathal S Mahon, Meredith E K Calvert, Darren Chan, Jason C Dugas, Ryan J Watts

J Exp Med· March 2022

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Todd Logan, Matthew J Simon, Anil Rana, Gerald M Cherf, Ankita Srivastava, Ryan J Watts

Cell· September 2021

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APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function.
Monica Xiong, Hong Jiang, Javier Remolina Serrano, Ernesto R Gonzales, Chao Wang, Ryan J Watts

Sci Transl Med· February 2021

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Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Julie C Ullman, Annie Arguello, Jennifer A Getz, Akhil Bhalla, Cathal S Mahon, Ryan J Watts

Sci Transl Med· May 2020

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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Mihalis S Kariolis, Robert C Wells, Jennifer A Getz, Wanda Kwan, Cathal S Mahon, Ryan J Watts

Sci Transl Med· May 2020

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TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Alicia A Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Ryan J Watts

Neuron· March 2020

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Deformation Microscopy for Dynamic Intracellular and Intranuclear Mapping of Mechanics with High Spatiotemporal Resolution.
Soham Ghosh, Benjamin Seelbinder, Jonathan T Henderson, Ryan D Watts, Adrienne K Scott

Cell Rep· April 2019

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SUPT4H1 Depletion Leads to a Global Reduction in RNA.
Adam Naguib, Thomas Sandmann, Fei Yi, Ryan J Watts, Joseph W Lewcock

Cell Rep· January 2019

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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
Fan Liao, Aimin Li, Monica Xiong, Nga Bien-Ly, Hong Jiang, Ryan J Watts

J Clin Invest· May 2018

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Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates.
Daniela Bumbaca Yadav, Janice A Maloney, Kristin R Wildsmith, Reina N Fuji, William J Meilandt, Ryan J Watts

Br J Pharmacol· November 2017

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US immigration order strikes against biotech.
Jeremy M Levin, Steven H Holtzman, John Maraganore, Paul J Hastings, Ron Cohen, Ryan J Watts

Nat Biotechnol· March 2017

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BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats.
Martin Weber, Tiffany Wu, William J Meilandt, Sara L Dominguez, Hilda O Solanoy, Ryan J Watts

Sci Rep· March 2017

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