Publications by authors named "Ryuichi Harada"

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Whole-body biodistribution of [F]SMBT-1: a novel PET tracer for monoamine oxidase B imaging in healthy humans.
Berihu Mesfin, Yui Ishioka, Yoshiki Ichinose, Akihito Inamura, Yingying Wu, Ryuichi Harada

Ann Nucl Med· January 2026

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Automated radiosynthesis and clinical experience of [F]SMBT-1 PET imaging for evaluation of reactive astrocyte in Parkinson's disease: a pilot study.
Peerapon Kiatkittikul, Pradith Lerdsirisuk, Laksika Bhuthathorn, Arthita Choolam, Attapon Jantarato, Ryuichi Harada

Front Nucl Med· December 2025

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Kinetic and quantitative analysis of [F]SMBT-1 PET imaging for monoamine oxidase B.
Kotaro Hiraoka, Berihu Mesfin, Yingying Wu, Yuki Shimizu, Asuka Kikuchi, Ryuichi Harada

Ann Nucl Med· November 2025

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[In vivo imaging of Alzheimer's disease lesion].
Nobuyuki Okamura, Rumi Nakayama-Naono, Ryuichi Harada

Nihon Yakurigaku Zasshi· November 2025

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Transmembrane protein 106B amyloid is a potential off-target molecule of tau PET tracers in the choroid plexus.
Yuka Yokoyama, Ryuichi Harada, Kaede Kudo, Ren Iwata, Yukitsuka Kudo

Nucl Med Biol· May 2025

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Visualization of Apolipoprotein E-Binding Amyloid Plaques in Postmortem Alzheimer's Disease Brains Using a Novel Fluorescent Probe THK-5320.
Ryuichi Harada, Kaede Kudo, Gonzalo Carmona Soto, Ren Iwata, Kazuhiko Yanai

ACS Chem Neurosci· May 2025

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Current Progress and Future Directions in Non-Alzheimer's Disease Tau PET Tracers.
Hendris Wongso, Ryuichi Harada, Shozo Furumoto

ACS Chem Neurosci· January 2025

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A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer's Disease Mouse Model.
Fumito Naganuma, Daiki Murata, Marie Inoue, Yuri Maehori, Ryuichi Harada

Mol Imaging Biol· December 2023

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Preclinical Characterization of the Tau PET Tracer [F]SNFT-1: Comparison of Tau PET Tracers.
Ryuichi Harada, Pradith Lerdsirisuk, Yuki Shimizu, Yuka Yokoyama, Yiqing Du

J Nucl Med· September 2023

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Evaluation of 18F labeled glial fibrillary acidic protein binding nanobody and its brain shuttle peptide fusion proteins using a neuroinflammation rat model.
Takahiro Morito, Ryuichi Harada, Ren Iwata, Yoichi Ishikawa, Nobuyuki Okamura

PLoS One· June 2023

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In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study.
Ryota Kobayashi, Tadaho Nakamura, Fumito Naganuma, Ryuichi Harada, Daichi Morioka

J Neuropathol Exp Neurol· April 2023

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[In vivo imaging of astrogliosis by PET].
Ryuichi Harada, Nobuyuki Okamura

Nihon Yakurigaku Zasshi· January 2023

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[Imaging of neuropathology by PET tracers].
Ryuichi Harada

Nihon Yakurigaku Zasshi· November 2022

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Assessing Reactive Astrogliosis with F-SMBT-1 Across the Alzheimer Disease Spectrum.
Victor L Villemagne, Ryuichi Harada, Vincent Doré, Shozo Furumoto, Rachel Mulligan

J Nucl Med· October 2022

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First-in-Humans Evaluation of F-SMBT-1, a Novel F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis.
Victor L Villemagne, Ryuichi Harada, Vincent Doré, Shozo Furumoto, Rachel Mulligan

J Nucl Med· October 2022

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[Is TSPO PET a biomarker of activated microglia?].
Ryuichi Harada

Nihon Yakurigaku Zasshi· September 2022

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[In vivo imaging of α-synuclein].
Ryuichi Harada

Nihon Yakurigaku Zasshi· July 2022

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The Role of Chirality of [F]SMBT-1 in Imaging of Monoamine Oxidase-B.
Ryuichi Harada, Yuki Shimizu, Yiqing Du, Yoichi Ishikawa, Ren Iwata

ACS Chem Neurosci· February 2022

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Imaging of Reactive Astrogliosis by Positron Emission Tomography.
Ryuichi Harada, Shozo Furumoto, Yukitsuka Kudo, Kazuhiko Yanai, Victor L Villemagne

Front Neurosci· February 2022

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F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies.
Michinori Ezura, Akio Kikuchi, Nobuyuki Okamura, Aiko Ishiki, Takafumi Hasegawa, Ryuichi Harada

Front Aging Neurosci· November 2021

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F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging.
Ryuichi Harada, Yoshimi Hayakawa, Michinori Ezura, Pradith Lerdsirisuk, Yiqing Du

J Nucl Med· February 2021

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Synthesis and evaluation of 2-pyrrolopyridinylquinoline derivatives as selective tau PET tracers for the diagnosis of Alzheimer's disease.
Pradith Lerdsirisuk, Ryuichi Harada, Yoshimi Hayakawa, Yuki Shimizu, Yoichi Ishikawa

Nucl Med Biol· February 2021

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Synthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody.
Takahiro Morito, Ryuichi Harada, Ren Iwata, Yiqing Du, Nobuyuki Okamura

Sci Rep· January 2021

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A concentration-based microscale method for F-nucleophilic substitutions and its testing on the one-pot radiosynthesis of [F]FET and [F]fallypride.
Ren Iwata, Kazunori Terasaki, Yoichi Ishikawa, Ryuichi Harada, Shozo Furumoto

Appl Radiat Isot· December 2020

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[Radiolabeled proteins for the development of biopharmaceuticals].
Ryuichi Harada, Takahiro Morito, Kazuhiko Yanai

Nihon Yakurigaku Zasshi· August 2020

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