Publications by authors named "Saito Higuchi"

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Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity.
Genzui Setsu, Megumi Goto, Kentaro Ito, Tomoe Taira, Masaya Miyamoto, Saito Higuchi

Biochem Biophys Res Commun· June 2024

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Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models.
Genzui Setsu, Megumi Goto, Kentaro Ito, Tomoe Taira, Masaya Miyamoto, Saito Higuchi

Eur J Pharmacol· December 2023

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Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.
Ryutaro Kanada, Yoshiko Kagoshima, Takashi Suzuki, Akifumi Nakamura, Hideaki Funami, Saito Higuchi

J Med Chem· January 2023

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Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring.
Ryutaro Kanada, Yoshiko Kagoshima, Masayoshi Asano, Takashi Suzuki, Takeshi Murata, Saito Higuchi

Bioorg Med Chem Lett· June 2022

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4-Pyridone-3-carboxylic acid as a benzoic acid bioisostere: Design, synthesis, and evaluation of EP300/CBP histone acetyltransferase inhibitors.
Ryutaro Kanada, Takashi Suzuki, Takeshi Murata, Masaki Miyazaki, Takashi Shimada, Saito Higuchi

Bioorg Med Chem Lett· November 2021

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Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient.
Steven J Wang, Saurabh Asthana, Annemieke van Zante, Chase M Heaton, Janyaporn Phuchareon, Saito Higuchi

Oral Oncol· June 2017

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Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression.
Hideaki Ogiwara, Mariko Sasaki, Takafumi Mitachi, Takahiro Oike, Saito Higuchi

Cancer Discov· April 2016

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Anti-multidrug-resistant Acinetobacter baumannii activity of DS-8587: In vitro activity and in vivo efficacy in a murine calf muscle infection model.
Saito Higuchi, Yuichi Kurosaka, Saori Uoyama, Kumi Yoshida, Megumi Chiba

J Infect Chemother· May 2014

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Characteristics of antibiotic resistance and sequence type of Acinetobacter baumannii clinical isolates in Japan and the antibacterial activity of DS-8587.
Saito Higuchi, Mototsugu Shikata, Megumi Chiba, Kazuki Hoshino, Naomasa Gotoh

J Infect Chemother· April 2014

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Potent in vitro antibacterial activity of DS-8587, a novel broad-spectrum quinolone, against Acinetobacter baumannii.
Saito Higuchi, Yoshikuni Onodera, Megumi Chiba, Kazuki Hoshino, Naomasa Gotoh

Antimicrob Agents Chemother· April 2013

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Effect of beta-1,6-glucan inhibitors on the invasion process of Candida albicans: potential mechanism of their in vivo efficacy.
Akihiro Kitamura, Saito Higuchi, Masato Hata, Katsuhiro Kawakami, Kumi Yoshida

Antimicrob Agents Chemother· September 2009

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In vitro and in vivo antibacterial activities of DC-159a, a new fluoroquinolone.
Kazuki Hoshino, Kazue Inoue, Yoichi Murakami, Yuichi Kurosaka, Kenji Namba, Saito Higuchi

Antimicrob Agents Chemother· January 2008

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Purification and cell-surface marker characterization of quiescent satellite cells from murine skeletal muscle by a novel monoclonal antibody.
So-ichiro Fukada, Saito Higuchi, Masashi Segawa, Ken-ichi Koda, Yukiko Yamamoto

Exp Cell Res· June 2004

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Muscle regeneration by reconstitution with bone marrow or fetal liver cells from green fluorescent protein-gene transgenic mice.
So-ichiro Fukada, Yuko Miyagoe-Suzuki, Hiroshi Tsukihara, Katsutoshi Yuasa, Saito Higuchi

J Cell Sci· March 2002

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