Publications by authors named "Sam Butterworth"

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Stabilisation of PRCP by deubiquitinase-targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy.
Fangchao Zhou, Jun Xia, Yingjuan Liu, Wenqi He, Hongyuan Zhang, Sam Butterworth

Br J Pharmacol· November 2025

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Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling.
Cameron E Taylor, Grace Roper, Rhianna Young, Fredrik Svensson, Andreas Brunschweiger, Sam Butterworth

RSC Med Chem· October 2025

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Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J Cooper, John Gordon, Sam Butterworth

Br J Pharmacol· July 2025

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XAT-Catalysis for Intramolecular Biaryl Synthesis.
Thomas Sephton, Jonathan M Large, Louise S Natrajan, Sam Butterworth, Michael F Greaney

Angew Chem Int Ed Engl· August 2024

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Comparison of the wastewater treatment performance of continuously and discontinuously mixed high-rate algal ponds at Kingston on Murray.
Sam Butterworth, Howard Fallowfield

Water Sci Technol· February 2024

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Aryne-Enabled C-N Arylation of Anilines.
Thomas Sephton, Anastasios Charitou, Cristina Trujillo, Jonathan M Large, Sam Butterworth

Angew Chem Int Ed Engl· December 2023

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Design of PLGA nanoparticles for sustained release of hydroxyl-FK866 by microfluidics.
Xue Bai, Siyuan Tang, Sam Butterworth, Annalisa Tirella

Biomater Adv· November 2023

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Synthesis of Functionalized Pyrrolidinone Scaffolds via Smiles-Truce Cascade.
Thomas Sephton, Jonathan M Large, Sam Butterworth, Michael F Greaney

Org Lett· September 2023

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Prolylcarboxypeptidase Alleviates Hypertensive Cardiac Remodeling by Regulating Myocardial Tissue Angiotensin II.
Binh Y Nguyen, Fangchao Zhou, Pablo Binder, Wei Liu, Susanne S Hille, Sam Butterworth

J Am Heart Assoc· June 2023

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Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators.
Siyuan Tang, Miguel Garzon Sanz, Oliver Smith, Andreas Krämer, Daniel Egbase, Sam Butterworth

Acta Pharm Sin B· February 2023

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Sustained Drug Release from Smart Nanoparticles in Cancer Therapy: A Comprehensive Review.
Xue Bai, Zara L Smith, Yuheng Wang, Sam Butterworth, Annalisa Tirella

Micromachines (Basel)· September 2022

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Diarylamine Synthesis via Desulfinylative Smiles Rearrangement.
Thomas Sephton, Jonathan M Large, Sam Butterworth, Michael F Greaney

Org Lett· February 2022

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Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity.
Nicholas J Cundy, Roseanna K Hare, Tina Tang, Andrew G Leach, Thomas A Jowitt, Sam Butterworth

RSC Chem Biol· December 2021

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eNAMPT Is Localised to Areas of Cartilage Damage in Patients with Hip Osteoarthritis and Promotes Cartilage Catabolism and Inflammation.
Ashleigh M Philp, Sam Butterworth, Edward T Davis, Simon W Jones

Int J Mol Sci· June 2021

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Circadian control of hepatitis B virus replication.
Xiaodong Zhuang, Donall Forde, Senko Tsukuda, Valentina D'Arienzo, Laurent Mailly, Sam Butterworth

Nat Commun· March 2021

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Investigation of the cytotoxicity of bioinspired coumarin analogues towards human breast cancer cells.
Leonidas Gkionis, Eleni Kavetsou, Alexandros Kalospyros, Dimitris Manousakis, Miguel Garzon Sanz, Sam Butterworth

Mol Divers· February 2021

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Backbone resonance assignments of the catalytic and regulatory domains of Ca/calmodulin-dependent protein kinase 1D.
Michael H G Tong, Mark Jeeves, Sundaresan Rajesh, Christian Ludwig, Marc Lenoir, Sam Butterworth

Biomol NMR Assign· October 2020

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Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity Mouse Model.
Christophe Fromont, Alessio Atzori, Divneet Kaur, Lubna Hashmi, Graziella Greco, Sam Butterworth

J Med Chem· July 2020

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Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.
Sophie R Sayers, Rebecca L Beavil, Nicholas H F Fine, Guo C Huang, Pratik Choudhary, Sam Butterworth

Diabetologia· February 2020

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DeepCDpred: Inter-residue distance and contact prediction for improved prediction of protein structure.
Shuangxi Ji, Tuğçe Oruç, Liam Mead, Muhammad Fayyaz Rehman, Christopher Morton Thomas, Sam Butterworth

PLoS One· September 2019

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The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication.
Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G Lai, Abhinav Kumar, Sam Butterworth

Nat Commun· January 2019

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The structure-guided discovery of osimertinib: the first U.S. FDA approved mutant selective inhibitor of EGFR T790M.
Sam Butterworth, Darren A E Cross, M Raymond V Finlay, Richard A Ward, Michael J Waring

Medchemcomm· May 2017

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Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.
Sam Butterworth, Michael Overduin, Alastair J Barr

Future Med Chem· August 2015

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2,2- and 2,6-Diarylpiperidines by aryl migration within lithiated urea derivatives of tetrahydropyridines.
Michael B Tait, Sam Butterworth, Jonathan Clayden

Org Lett· March 2015

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Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
M Raymond V Finlay, Mark Anderton, Susan Ashton, Peter Ballard, Paul A Bethel, Sam Butterworth

J Med Chem· October 2014

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