Publications by authors named "Sam G Gu"

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Hypoxia-induced metastatic heterogeneity in pancreatic cancer.
Pradeep Moon Gunasekaran, Qianqian Wang, Yoke-Chen Chang, Polina Guseva, Rajika Chauhan, Sam Guoping Gu

Res Sq· October 2025

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Hypoxia-induced metastatic heterogeneity in pancreatic cancer.
Pradeep Moon Gunasekaran, Qianqian Wang, Yoke-Chen Chang, Polina Guseva, Rajika Chauhan, Sam Guoping Gu

bioRxiv· August 2025

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Two H3K23 histone methyltransferases, SET-32 and SET-21, function synergistically to promote nuclear RNAi-mediated transgenerational epigenetic inheritance in Caenorhabditis elegans.
Anna Zhebrun, Julie Z Ni, Laura Corveleyn, Siddharth Ghosh Roy, Simone Sidoli, Sam G Gu

Genetics· February 2025

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Two H3K23 histone methyltransferases, SET-32 and SET-21, function synergistically to promote nuclear RNAi-mediated transgenerational epigenetic inheritance in .
Anna Zhebrun, Julie Z Ni, Laura Corveleyn, Siddharth Ghosh Roy, Simone Sidoli, Sam G Gu

bioRxiv· November 2024

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SPE-51, a sperm-secreted protein with an immunoglobulin-like domain, is required for fertilization in C. elegans.
Xue Mei, Katherine A Maniates, A'maya Looper, Amber R Krauchunas, Marina Druzhinina, Gunasekaran Singaravelu, Sam Guoping Gu

Curr Biol· July 2023

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Reprogramming the piRNA pathway for multiplexed and transgenerational gene silencing in C. elegans.
Monika Priyadarshini, Julie Zhouli Ni, Amhed M Vargas-Velazquez, Sam Guoping Gu, Christian Frøkjær-Jensen

Nat Methods· February 2022

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nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3.
Lianna Schwartz-Orbach, Chenzhen Zhang, Simone Sidoli, Richa Amin, Diljeet Kaur, Sam G Gu

Elife· August 2020

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C. elegans Heterochromatin Factor SET-32 Plays an Essential Role in Transgenerational Establishment of Nuclear RNAi-Mediated Epigenetic Silencing.
Natallia Kalinava, Julie Zhouli Ni, Zoran Gajic, Matthew Kim, Helen Ushakov, Sam Guoping Gu

Cell Rep· November 2018

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The spatial and temporal dynamics of nuclear RNAi-targeted retrotransposon transcripts in .
Julie Zhouli Ni, Natallia Kalinava, Sofia Galindo Mendoza, Sam Guoping Gu

Development· October 2018

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The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes.
Yanmei Zhao, Chieh-Hsiang Tan, Amber Krauchunas, Andrea Scharf, Nicholas Dietrich, Sam Guoping Gu

PLoS Biol· June 2018

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spe-43 is required for sperm activation in C. elegans.
Amber R Krauchunas, Ernesto Mendez, Julie Zhouli Ni, Marina Druzhinina, Amanda Mulia, Sam Guoping Gu

Dev Biol· April 2018

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Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in .
Natallia Kalinava, Julie Zhouli Ni, Kimberly Peterman, Esteban Chen, Sam Guoping Gu

Epigenetics Chromatin· January 2018

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MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality.
Natasha E Weiser, Danny X Yang, Suhua Feng, Natallia Kalinava, Kristen C Brown, Sam G Gu

Dev Cell· May 2017

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A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegans.
Julie Zhouli Ni, Natallia Kalinava, Esteban Chen, Alex Huang, Thi Trinh, Sam Guoping Gu

Epigenetics Chromatin· January 2016

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Complex coding of endogenous siRNA, transcriptional silencing and H3K9 methylation on native targets of germline nuclear RNAi in C. elegans.
Julie Zhouli Ni, Esteban Chen, Sam Guoping Gu

BMC Genomics· December 2014

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The transcription start site landscape of C. elegans.
Taro Leo Saito, Shin-ichi Hashimoto, Sam Guoping Gu, J Jason Morton, Michael Stadler

Genome Res· August 2013

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A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality.
Bethany A Buckley, Kirk B Burkhart, Sam Guoping Gu, George Spracklin, Aaron Kershner

Nature· September 2012

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Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint.
Sam Guoping Gu, Julia Pak, Shouhong Guang, Jay M Maniar, Scott Kennedy

Nat Genet· January 2012

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The conformation of microRNA seed regions in native microRNPs is prearranged for presentation to mRNA targets.
Nicole J Lambert, Sam G Gu, Alan M Zahler

Nucleic Acids Res· June 2011

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Distributed probing of chromatin structure in vivo reveals pervasive chromatin accessibility for expressed and non-expressed genes during tissue differentiation in C. elegans.
Ky Sha, Sam G Gu, Luiz C Pantalena-Filho, Amy Goh, Jamie Fleenor

BMC Genomics· August 2010

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Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls.
Daniela Witten, Robert Tibshirani, Sam Guoping Gu, Andrew Fire, Weng-Onn Lui

BMC Biol· May 2010

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Partitioning the C. elegans genome by nucleosome modification, occupancy, and positioning.
Sam Guoping Gu, Andrew Fire

Chromosoma· February 2010

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A Caenorhabditis elegans RNA-directed RNA polymerase in sperm development and endogenous RNA interference.
Jonathan I Gent, Mara Schvarzstein, Anne M Villeneuve, Sam Guoping Gu, Verena Jantsch

Genetics· December 2009

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Chromatin-associated periodicity in genetic variation downstream of transcriptional start sites.
Shin Sasaki, Cecilia C Mello, Atsuko Shimada, Yoichiro Nakatani, Shin-Ichi Hashimoto, Sam Guoping Gu

Science· January 2009

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Distinct ribonucleoprotein reservoirs for microRNA and siRNA populations in C. elegans.
Sam G Gu, Julia Pak, Sergio Barberan-Soler, Mustapha Ali, Andrew Fire

RNA· September 2007

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