Publications by authors named "Sam Groombridge"

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Generation of a potent & selective series of IRAK4 inhibitors based on a structure based, hybridization approach.
Ina Terstiege, Anna Aagaard, Kristina Berggren, James Bird, Iain A Cumming, Sam D Groombridge

Bioorg Med Chem· December 2025

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Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.
Iain A Cumming, Sébastien L Degorce, Anna Aagaard, Erin L Braybrooke, Nichola L Davies, Sam D Groombridge

Bioorg Med Chem· June 2022

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Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.
James S Scott, Andrew Bailey, David Buttar, Rodrigo J Carbajo, Jon Curwen, Sam D Groombridge

J Med Chem· February 2019

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Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.
Sébastien L Degorce, Rana Anjum, Keith S Dillman, Lisa Drew, Sam D Groombridge

Bioorg Med Chem· February 2018

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Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88 Diffuse Large B-Cell Lymphoma.
James S Scott, Sébastien L Degorce, Rana Anjum, Janet Culshaw, Robert D M Davies, Sam D Groombridge

J Med Chem· December 2017

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The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1.
Linda Sundström, Susanna Myhre, Monika Sundqvist, Andrea Ahnmark, William McCoull, Sam D Groombridge

PLoS One· December 2017

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Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.
Scott Boyd, Joanna L Brookfield, Susan E Critchlow, Iain A Cumming, Nicola J Curtis, Sam Groombridge

J Med Chem· April 2015

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Optimization of brain penetrant 11β-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice.
Frederick W Goldberg, Alexander G Dossetter, James S Scott, Graeme R Robb, Scott Boyd, Sam D Groombridge

J Med Chem· February 2014

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Conformational restriction in a series of GPR119 agonists: differences in pharmacology between mouse and human.
James S Scott, Katy J Brocklehurst, Hayley S Brown, David S Clarke, Helen Coe, Sam D Groombridge

Bioorg Med Chem Lett· June 2013

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Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.
Frederick W Goldberg, Andrew G Leach, James S Scott, Wendy L Snelson, Sam D Groombridge

J Med Chem· December 2012

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Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors.
James S Scott, Adrian L Gill, Linda Godfrey, Sam D Groombridge, Amanda Rees

Bioorg Med Chem Lett· November 2012

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Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.
James S Scott, Alan M Birch, Katy J Brocklehurst, Anders Broo, Hayley S Brown, Sam D Groombridge

J Med Chem· June 2012

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Rationally designing safer anilines: the challenging case of 4-aminobiphenyls.
Alan M Birch, Sam Groombridge, Robert Law, Andrew G Leach, Christine D Mee

J Med Chem· April 2012

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Discovery, optimisation and in vivo evaluation of novel GPR119 agonists.
Katy J Brocklehurst, Anders Broo, Roger J Butlin, Hayley S Brown, David S Clarke, Sam D Groombridge

Bioorg Med Chem Lett· December 2011

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