Publications by authors named "Samar H Abbas"

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Antimicrobial activity and antifungal mechanistic study of 3‑substituted oxindoles against Aspergillus niger.
Hend A A Ezelarab, Maisra M El-Bouseary, Ramadan Yahia, Rehab Mahmoud Abd El-Baky, Mohamed A Mawhoup, Samar H Abbas

Sci Rep· November 2025

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Benzimidazole scaffold as a potent anticancer agent with different mechanisms of action (2016-2023).
Fatma Fouad Hagar, Samar H Abbas, Eman Atef, Dalia Abdelhamid, Mohamed Abdel-Aziz

Mol Divers· April 2025

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New antiproliferative 1,3,4-oxadiazole/benzimidazole derivatives: Design, synthesis, and biological evaluation as dual EGFR and BRAF inhibitors.
Fatma Fouad Hagar, Samar H Abbas, Ahmed M Sayed, Hesham A M Gomaa, Bahaa G M Youssif

Bioorg Chem· April 2025

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Quinazoline-chalcone hybrids as HDAC/EGFR dual inhibitors: Design, synthesis, mechanistic, and in-silico studies of potential anticancer activity against multiple myeloma.
Mostafa A Mansour, Asmaa M AboulMagd, Samar H Abbas, Mohamed Abdel-Aziz, Hamdy M Abdel-Rahman

Arch Pharm (Weinheim)· May 2024

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New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization.
Hend A A Ezelarab, Taha F S Ali, Samar H Abbas, Ahmed M Sayed, Eman A M Beshr

Mol Divers· April 2024

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New 2-oxoindole derivatives as multiple PDGFRα/ß and VEGFR-2 tyrosine kinase inhibitors.
Hend A A Ezelarab, Amer Ali Abd El-Hafeez, Taha F S Ali, Ahmed M Sayed, Heba A Hassan, Samar H Abbas

Bioorg Chem· April 2024

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Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy.
Mostafa M Badran, Samar H Abbas, Hiroshi Tateishi, Yuki Maemoto, Tsugumasa Toma

Eur J Med Chem· April 2024

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Harnessing pyrimidine as a building block for histone deacetylase inhibitors.
Mostafa M Badran, Samar H Abbas, Mikako Fujita, Mohamed Abdel-Aziz

Arch Pharm (Weinheim)· October 2023

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Chalcone/1,3,4-Oxadiazole/Benzimidazole hybrids as novel anti-proliferative agents inducing apoptosis and inhibiting EGFR & BRAFV.
Fatma Fouad Hagar, Samar H Abbas, Hesham A M Gomaa, Bahaa G M Youssif, Ahmed M Sayed

BMC Chem· September 2023

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Synthesis and molecular docking of new N4-piperazinyl ciprofloxacin hybrids as antimicrobial DNA gyrase inhibitors.
Hamada H H Mohammed, Doaa Mohamed Elroby Ali, Mohamed Badr, Ahmed G K Habib, Abobakr Mohamed Mahmoud, Samar H Abbas

Mol Divers· August 2023

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Indole-based FLT3 inhibitors and related scaffolds as potential therapeutic agents for acute myeloid leukemia.
Hend A A Ezelarab, Taha F S Ali, Samar H Abbas, Heba A Hassan, Eman A M Beshr

BMC Chem· July 2023

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Insights into fourth generation selective inhibitors of (C797S) EGFR mutation combating non-small cell lung cancer resistance: a critical review.
Mostafa A Mansour, Asmaa M AboulMagd, Samar H Abbas, Hamdy M Abdel-Rahman, Mohamed Abdel-Aziz

RSC Adv· June 2023

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New 1,3,4-oxadiazole-chalcone/benzimidazole hybrids as potent antiproliferative agents.
Fatma Fouad Hagar, Samar H Abbas, Dalia Abdelhamid, Hesham A M Gomaa, Bahaa G M Youssif

Arch Pharm (Weinheim)· February 2023

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New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization.
Hamada H H Mohammed, Amer Ali Abd El-Hafeez, Kareem Ebeid, Aml I Mekkawy, Mohammed A S Abourehab, Samar H Abbas

J Enzyme Inhib Med Chem· December 2022

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Synthesis and antimicrobial evaluation of new nitric oxide-donating fluoroquinolone/oxime hybrids.
Hossameldin A Aziz, Gamal A I Moustafa, Gamal El-Din A Abuo-Rahma, Safwat M Rabea, Glenn Hauk, Samar H Abbas

Arch Pharm (Weinheim)· January 2021

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Novel urea linked ciprofloxacin-chalcone hybrids having antiproliferative topoisomerases I/II inhibitory activities and caspases-mediated apoptosis.
Hamada H H Mohammed, Samar H Abbas, Alaa M Hayallah, Gamal El-Din A Abuo-Rahma, Yaser A Mostafa

Bioorg Chem· January 2021

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Current Trends and Future Directions of Fluoroquinolones.
Hamada H H Mohammed, Gamal El-Din A A Abuo-Rahma, Samar H Abbas, El-Shimaa M N Abdelhafez

Curr Med Chem· October 2019

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Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity.
Hamada H H Mohammed, El-Shimaa M N Abdelhafez, Samar H Abbas, Gamal A I Moustafa, Glenn Hauk

Bioorg Chem· July 2019

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1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities.
Marwa Ali A Fathi, Amer Ali Abd El-Hafeez, Dalia Abdelhamid, Samar H Abbas, Monica M Montano

Bioorg Chem· March 2019

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New quinoline/chalcone hybrids as anti-cancer agents: Design, synthesis, and evaluations of cytotoxicity and PI3K inhibitory activity.
Samar H Abbas, Amer Ali Abd El-Hafeez, Mai E Shoman, Monica M Montano, Heba A Hassan

Bioorg Chem· February 2019

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Recent updates of fluoroquinolones as antibacterial agents.
Hend A A Ezelarab, Samar H Abbas, Heba A Hassan, Gamal El-Din A Abuo-Rahma

Arch Pharm (Weinheim)· September 2018

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New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells.
Fatma F Ahmed, Amer Ali Abd El-Hafeez, Samar H Abbas, Dalia Abdelhamid, Mohamed Abdel-Aziz

Eur J Med Chem· May 2018

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New antiproliferative 7-(4-(N-substituted carbamoylmethyl)piperazin-1-yl) derivatives of ciprofloxacin induce cell cycle arrest at G2/M phase.
Hamada H H Mohammed, Amer Ali Abd El-Hafeez, Samar H Abbas, El-Shimaa M N Abdelhafez, Gamal El-Din A Abuo-Rahma

Bioorg Med Chem· October 2016

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Synthesis, cytotoxic activity, and tubulin polymerization inhibitory activity of new pyrrol-2(3H)-ones and pyridazin-3(2H)-ones.
Samar Hafez Abbas, Gamal El-Din A A Abuo-Rahma, Mohamed Abdel-Aziz, Omar M Aly, Eman A Beshr

Bioorg Chem· June 2016

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