Publications by authors named "Samit Joshi"

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Efficacy and safety of the HIV-1 maturation inhibitor GSK3640254 plus two NRTIs in adults naive to antiretroviral therapy (DOMINO): 24-week results from a randomised phase 2b study.
Samit R Joshi, Ezequiel Cordova, Essack Mitha, Antonella Castagna, Moti Ramgopal, Aditya Joshi

EClinicalMedicine· November 2025

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Efficacy and safety of the HIV-1 maturation inhibitor GSK3640254 plus dolutegravir as a two-drug regimen in adults naive to antiretroviral therapy (DYNAMIC): 24-week results from a randomised phase 2b study.
Samit R Joshi, Mar Masiá, Essack Mitha, Antonella Castagna, Ezequiel Cordova

EClinicalMedicine· November 2025

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Exploring HIV-1 Maturation: A New Frontier in Antiviral Development.
Aidan McGraw, Grace Hillmer, Stefania M Medehincu, Yuta Hikichi, Sophia Gagliardi, Samit Joshi

Viruses· September 2024

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Pharmacokinetics and tolerability of the maturation inhibitor GSK3640254 coadministered with darunavir/ritonavir and/or etravirine in healthy adults.
Ying Zhang, Samit Joshi, Parto Yazdani, Joyce Zhan, Bo Wen

Br J Clin Pharmacol· January 2024

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Effects of the HIV-1 maturation inhibitor GSK3640254 on QT interval in healthy participants.
Ying Zhang, Mark Bush, Parto Yazdani, Joyce Zhan, Bo Wen, Samit Joshi

Pharmacol Res Perspect· December 2023

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Open-label, drug-drug interaction study between the HIV-1 maturation inhibitor GSK3640254 and a metabolic probe cocktail in healthy participants.
Ying Zhang, Mark Johnson, Samit Joshi, Parto Yazdani, Joyce Zhan

Br J Clin Pharmacol· July 2023

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Phase IIa Proof-of-Concept Evaluation of the Antiviral Efficacy, Safety, Tolerability, and Pharmacokinetics of the Next-Generation Maturation Inhibitor GSK3640254.
Christoph D Spinner, Franco Felizarta, Giuliano Rizzardini, Patrick Philibert, Essack Mitha, Samit R Joshi

Clin Infect Dis· September 2022

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Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults.
Chih-Hung Chou, Subhasis Mohanty, Heather A Kang, Lingjia Kong, Julian Avila-Pacheco, Samit R Joshi

Aging Cell· September 2022

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Relative Bioavailability and Food Effect of GSK3640254 Tablet and Capsule Formulations in Healthy Participants.
Mark Johnson, Teodora Pene Dumitrescu, Samit R Joshi, Ashwin Mathew, Veronica Bainbridge

Clin Pharmacol Drug Dev· May 2022

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Lack of pharmacokinetic interaction between the HIV-1 maturation inhibitor GSK3640254 and combination oral contraceptives in healthy women.
Teodora Pene Dumitrescu, Thomas J Greene, Samit R Joshi, Jianfeng Xu, Mark Johnson

Br J Clin Pharmacol· February 2022

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Phase I evaluation of pharmacokinetics and tolerability of the HIV-1 maturation inhibitor GSK3640254 and dolutegravir in healthy adults.
Teodora Pene Dumitrescu, Samit R Joshi, Jianfeng Xu, Thomas J Greene, Mark Johnson

Br J Clin Pharmacol· September 2021

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A Phase I Evaluation of the Pharmacokinetics and Tolerability of the HIV-1 Maturation Inhibitor GSK3640254 and Tenofovir Alafenamide/Emtricitabine in Healthy Participants.
Teodora Pene Dumitrescu, Samit R Joshi, Jianfeng Xu, Joyce Zhan, Mark Johnson

Antimicrob Agents Chemother· May 2021

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Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next-generation HIV-1 maturation inhibitor.
Samit R Joshi, Disala Fernando, Stephanie Igwe, Litza McKenzie, Anu S Krishnatry

Pharmacol Res Perspect· December 2020

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Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study.
Ira Dicker, Sharon Zhang, Neelanjana Ray, Brett R Beno, Alicia Regueiro-Ren, Samit Joshi

PLoS One· March 2020

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Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial.
Javier Morales-Ramirez, Johannes R Bogner, Jean-Michel Molina, Johan Lombaard, Ira B Dicker, Samit R Joshi

PLoS One· March 2019

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Safety and efficacy of the HIV-1 attachment inhibitor prodrug fostemsavir in antiretroviral-experienced subjects: week 48 analysis of AI438011, a Phase IIb, randomized controlled trial.
Melanie Thompson, Jacob P Lalezari, Richard Kaplan, Yvett Pinedo, Otto A Sussmann Pena, Samit R Joshi

Antivir Ther· March 2018

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Viral Drug Resistance Through 48 Weeks, in a Phase 2b, Randomized, Controlled Trial of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir.
Max Lataillade, Nannan Zhou, Samit R Joshi, Sangil Lee, David A Stock

J Acquir Immune Defic Syndr· March 2018

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Multiple network-constrained regressions expand insights into influenza vaccination responses.
Stefan Avey, Subhasis Mohanty, Jean Wilson, Heidi Zapata, Samit R Joshi

Bioinformatics· July 2017

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Multicolor Digital Flow Cytometry in Human Translational Immunology.
Samit R Joshi, Subhasis Mohanty, Albert C Shaw

Methods Mol Biol· June 2016

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Model-Based Phase 3 Dose Selection for HIV-1 Attachment Inhibitor Prodrug BMS-663068 in HIV-1-Infected Patients: Population Pharmacokinetics/Pharmacodynamics of the Active Moiety, BMS-626529.
Ishani Landry, Li Zhu, Malaz Abu Tarif, Matthew Hruska, Brian M Sadler, Samit Joshi

Antimicrob Agents Chemother· May 2016

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Safety profile of HIV-1 attachment inhibitor prodrug BMS-663068 in antiretroviral-experienced subjects: week 24 analysis.
Jacob Lalezari, Gulam H Latiff, Cynthia Brinson, Juan Echevarria, Sandra Treviño-Pérez, Samit R Joshi

J Int AIDS Soc· January 2016

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Efficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): a phase 2b randomised, controlled, partly blinded trial.
Samir K Gupta, Grace A McComsey, John Lombaard, Juan Echevarría, Catherine Orrell, Samit R Joshi

Lancet HIV· January 2016

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Safety and efficacy of the HIV-1 attachment inhibitor prodrug BMS-663068 in treatment-experienced individuals: 24 week results of AI438011, a phase 2b, randomised controlled trial.
Jacob P Lalezari, Gulam H Latiff, Cynthia Brinson, Juan Echevarría, Sandra Treviño-Pérez, Samit R Joshi

Lancet HIV· October 2015

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Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.
Wendy E Walker, Sebastian Kurscheid, Samit Joshi, Charlie A Lopez, Gerald Goh

J Virol· May 2015

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Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination.
Juilee Thakar, Subhasis Mohanty, A Phillip West, Samit R Joshi, Ikuyo Ueda

Aging (Albany NY)· January 2015

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