Publications by authors named "Samrat Thouta"

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Molecular Pharmacology of Selective Na1.6 and Dual Na1.6/Na1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo.
Samuel J Goodchild, Noah Gregory Shuart, Aaron D Williams, Wenlei Ye, R Ryley Parrish, Samrat Thouta

ACS Chem Neurosci· March 2024

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Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and seizures.
Samrat Thouta, Matthew G Waldbrook, Sophia Lin, Arjun Mahadevan, Janette Mezeyova

Front Cell Neurosci· September 2022

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K1.1 channels mediate network excitability and feed-forward inhibition in local amygdala circuits.
Samrat Thouta, Yiming Zhang, Esperanza Garcia, Terrance P Snutch

Sci Rep· July 2021

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Modulation of hERG K Channel Deactivation by Voltage Sensor Relaxation.
Yu Patrick Shi, Samrat Thouta, Thomas W Claydon

Front Pharmacol· February 2020

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The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Jordan J Shimell, Bhavin S Shah, Stuart M Cain, Samrat Thouta, Naila Kuhlmann

Cell Rep· November 2019

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Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation.
Yu Patrick Shi, Samrat Thouta, Yen May Cheng, Tom W Claydon

J Gen Physiol· February 2019

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Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.
Samrat Thouta, Garman Lo, Lukas Grajauskas, Tom Claydon

Sci Rep· March 2018

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Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy.
Anna Lehman, Samrat Thouta, Grazia M S Mancini, Sakkubai Naidu, Marjon van Slegtenhorst

Am J Hum Genet· July 2017

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Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker.
Samrat Thouta, Christina M Hull, Yu Patrick Shi, Valentine Sergeev, James Young

Biophys J· January 2017

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NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Jiqing Guo, Yen May Cheng, James P Lees-Miller, Laura L Perissinotti, Tom W Claydon, Samrat Thouta

Biophys J· March 2015

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Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.
Samrat Thouta, Stanislav Sokolov, Yuki Abe, Sheldon J Clark, Yen M Cheng

Biophys J· March 2014

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Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain.
Frederick W Muskett, Samrat Thouta, Steven J Thomson, Alexander Bowen, Phillip J Stansfeld

J Biol Chem· February 2011

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