Publications by authors named "Tom Claydon"

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Development of an Absolute Quantification Method for hERG Using PRM with Single Isotopologue in-Sample Calibration.
Ge Chang, Fabusuyi A Aroge, Ravichandra Venkateshappa, Tom W Claydon, Bingyun Sun

ACS Omega· August 2024

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Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/- long QT syndrome variant.
Ravichandra Venkateshappa, Diana V Hunter, Priya Muralidharan, Raghu S Nagalingam, Galvin Huen, Tom W Claydon

Cardiovasc Res· November 2023

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Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome.
Kyle E Simpson, Ravichandra Venkateshappa, Zhao Kai Pang, Shoaib Faizi, Glen F Tibbits, Tom W Claydon

Front Physiol· January 2021

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Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds.
Christina M Hull, Christine E Genge, Yuki Hobbs, Kaveh Rayani, Eric Lin, Tom W Claydon

Am J Physiol Regul Integr Comp Physiol· December 2019

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Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation.
Yu Patrick Shi, Samrat Thouta, Yen May Cheng, Tom W Claydon

J Gen Physiol· February 2019

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Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.
Samrat Thouta, Garman Lo, Lukas Grajauskas, Tom Claydon

Sci Rep· March 2018

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NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Jiqing Guo, Yen May Cheng, James P Lees-Miller, Laura L Perissinotti, Tom W Claydon

Biophys J· March 2015

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Regional flexibility in the S4-S5 linker regulates hERG channel closed-state stabilization.
Christina M Hull, Stanislav Sokolov, Aaron C Van Slyke, Tom W Claydon

Pflugers Arch· October 2014

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External protons destabilize the activated voltage sensor in hERG channels.
Yu Patrick Shi, Yen May Cheng, Aaron C Van Slyke, Tom W Claydon

Eur Biophys J· March 2014

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Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.
Samrat Thouta, Stanislav Sokolov, Yuki Abe, Sheldon J Clark, Yen M Cheng, Tom W Claydon

Biophys J· March 2014

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Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels.
Yen May Cheng, Christina M Hull, Christine M Niven, Ji Qi, Charlene R Allard, Tom W Claydon

J Gen Physiol· September 2013

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Proton sensors in the pore domain of the cardiac voltage-gated sodium channel.
David K Jones, Colin H Peters, Charlene R Allard, Tom W Claydon, Peter C Ruben

J Biol Chem· February 2013

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Voltage-dependent gating of HERG potassium channels.
Yen May Cheng, Tom W Claydon

Front Pharmacol· October 2012

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Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis.
Aaron C Van Slyke, Yen May Cheng, Pouya Mafi, Charlene R Allard, Christina M Hull, Tom W Claydon

Am J Physiol Cell Physiol· June 2012

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Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
Aaron C Van Slyke, Saman Rezazadeh, Mischa Snopkowski, Patrick Shi, Charlene R Allard, Tom W Claydon

Biophys J· November 2010

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A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels.
Samy M Y Makary, Tom W Claydon, Decha Enkvetchakul, Colin G Nichols, Mark R Boyett

J Physiol· November 2005

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