Publications by authors named "Samsher Singh"

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A Mycobacteria-Specific Prodrug to Overcome Phenotypic AMR in .
T Anand Kumar, Shalini Birua, Sharath Chandra Mallojjala, Piyali Mukherjee, Samsher Singh, Amit Singh

J Med Chem· December 2025

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5-(3, 4-methylenedioxyphenyl)-4-ethyl-2E, 4E-pentadienoic acid piperidide as MdeA efflux pump inhibitor of Staphylococcus aureus.
Rahul Bhat, Neha Jeena, Samsher Singh, Nitin Pal Kalia, Narendra Singh Chauhan

Biochimie· October 2025

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A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in .
Samsher Singh, Ria Sorayah, Yushu Chen, Claire V Mulholland, Wassim Daher

bioRxiv· October 2025

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An Arm-to-Disarm Strategy to Overcome Phenotypic AMR in .
T Anand Kumar, Shalini Birua, M SharathChandra, Piyali Mukherjee, Samsher Singh, Amit Singh

bioRxiv· January 2024

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GaMF1.39's antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876.
Priya Ragunathan, Pearly Shuyi Ng, Samsher Singh, Wee Han Poh, Dennis Litty

Microbiol Spectr· December 2023

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Rationally Designed Novel Phenyloxazoline Synthase Inhibitors: Chemical Synthesis and Biological Evaluation to Accelerate the Discovery of New Antimycobacterial Antibiotics.
Mousumi Shyam, Gourab Bhattacharje, Chris Daniel, Amrendra Kumar, Pragya Yadav, Samsher Singh, Amit Singh

Molecules· December 2023

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Inhibiting respiration as a novel antibiotic strategy.
Bei Shi Lee, Samsher Singh, Kevin Pethe

Curr Opin Microbiol· August 2023

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Rifaximin potentiates clarithromycin against and in zebrafish.
Boon Chong Goh, Simon Larsson, Linh Chi Dam, Yan Han Sharon Ling, Wei Lin Patrina Chua, Samsher Singh

JAC Antimicrob Resist· June 2023

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M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments.
Nitin Pal Kalia, Samsher Singh, Kiel Hards, Chen-Yi Cheung, Ekaterina Sviriaeva

Cell Rep· May 2023

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Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species.
Somnath Shee, Samsher Singh, Ashutosh Tripathi, Chandrani Thakur, Anand Kumar T, Amit Singh

Antimicrob Agents Chemother· September 2022

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Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.
Mousumi Shyam, Harshita Verma, Gourab Bhattacharje, Piyali Mukherjee, Samsher Singh, Amit Singh

J Med Chem· January 2022

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Mevo lectin specificity toward high-mannose structures with terminal αMan(1,2)αMan residues and its implication to inhibition of the entry of Mycobacterium tuberculosis into macrophages.
Nukathoti Sivaji, Nikitha Harish, Samsher Singh, Amit Singh, Mamannamana Vijayan

Glycobiology· September 2021

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14-Residue peptaibol velutibol A from : its structural and cytotoxic evaluation.
Varun Pratap Singh, Anup Singh Pathania, Manoj Kushwaha, Samsher Singh, Vandana Sharma, Deepika Singh

RSC Adv· August 2020

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Synthesis of amides from (E)-3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus.
Santosh K Rath, Samsher Singh, Sunil Kumar, Naiem A Wani, Rajkishor Rai

Bioorg Med Chem· January 2019

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Physicochemical, pharmacokinetic, efficacy and toxicity profiling of a potential nitrofuranyl methyl piperazine derivative IIIM-MCD-211 for oral tuberculosis therapy via in-silico-in-vitro-in-vivo approach.
Asmita Magotra, Anjna Sharma, Samsher Singh, Probir Kumar Ojha, Sunil Kumar, Parvinder Pal Singh, Gurdarshan Singh

Pulm Pharmacol Ther· February 2018

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Boeravinone B, A Novel Dual Inhibitor of NorA Bacterial Efflux Pump of and Human -Glycoprotein, Reduces the Biofilm Formation and Intracellular Invasion of Bacteria.
Samsher Singh, Nitin P Kalia, Prashant Joshi, Ajay Kumar, Parduman R Sharma

Front Microbiol· October 2017

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Amino acid amides of piperic acid (PA) and 4-ethylpiperic acid (EPA) as NorA efflux pump inhibitors of Staphylococcus aureus.
Naiem Ahmad Wani, Samsher Singh, Saleem Farooq, Sudha Shankar, Surrinder Koul

Bioorg Med Chem Lett· September 2016

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Identification and characterization of novel small molecule inhibitors of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU).
Rashmi Sharma, Chitra Rani, Rukmankesh Mehra, Amit Nargotra, Reena Chib, Samsher Singh

Appl Microbiol Biotechnol· April 2016

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Nitrofuranyl Methyl Piperazines as New Anti-TB Agents: Identification, Validation, Medicinal Chemistry, and PK Studies.
Kushalava Reddy Yempalla, Gurunadham Munagala, Samsher Singh, Asmita Magotra, Sunil Kumar, Vikrant Singh Rajput, G D Singh, Parvinder Pal Singh

ACS Med Chem Lett· October 2015

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Synthesis and Biological Evaluation of Polar Functionalities Containing Nitrodihydroimidazooxazoles as Anti-TB Agents.
Kushalava Reddy Yempalla, Gurunadham Munagala, Samsher Singh, Gurleen Kour, Shweta Sharma, G D Singh, Parvinder Pal Singh

ACS Med Chem Lett· October 2015

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Synthesis, antimalarial and antitubercular activities of meridianin derivatives.
Rammohan R Yadav, Shabana I Khan, Samsher Singh, Inshad A Khan, Ram A Vishwakarma

Eur J Med Chem· June 2015

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Evaluation of functional properties of composite flours and sensorial attributes of composite flour biscuits.
Suresh Chandra, Samsher Singh, Durvesh Kumari

J Food Sci Technol· June 2015

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Discovery of 4-acetyl-3-(4-fluorophenyl)-1-(p-tolyl)-5-methylpyrrole as a dual inhibitor of human P-glycoprotein and Staphylococcus aureus Nor A efflux pump.
Jaideep B Bharate, Samsher Singh, Abubakar Wani, Sadhana Sharma, Prashant Joshi

Org Biomol Chem· May 2015

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Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: in vitro, structure-activity relationship, pharmacokinetics and in vivo evaluation.
Gurunadham Munagala, Kushalava Reddy Yempalla, Samsher Singh, Sumit Sharma, Nitin Pal Kalia, Vikrant Singh Rajput, Parvinder Pal Singh

Org Biomol Chem· March 2015

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