Publications by authors named "Samuel Bloom"

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Senolytic therapy increases replicative capacity by eliminating senescent endothelial cells.
Hossein Abdeahad, Denisse G Moreno, Samuel I Bloom, Hui Huang, Lisa A Lesniewski

Exp Gerontol· November 2025

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MitoQ reduces senescence burden in doxorubicin-treated endothelial cells by reducing mitochondrial ROS and DNA damage.
Hossein Abdeahad, Denisse G Moreno, Samuel I Bloom, Lucas Norman, Lisa A Lesniewski

Am J Physiol Heart Circ Physiol· November 2025

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Telomeres at the nexus of aging, tumor suppression, and inflammation: toward an understanding beyond senescence.
Samuel I Bloom, Jan Karlseder

Genes Dev· August 2025

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Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies.
Sophia A Mahoney, Samuel I Bloom, Douglas R Seals, Anthony J Donato, Matthew J Rossman

J Cardiovasc Aging· March 2025

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Prospective Outpatient Follow-Up of Early Cognitive Impairment in Patients with Mild Traumatic Brain Injury and Intracranial Hemorrhage.
Mallory Jebbia, Stephen Stopenski, Areg Grigorian, Catherine Kuza, Samuel Bloom

J Am Coll Surg· October 2024

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Endothelial-Specific Reduction in Arf6 Impairs Insulin-Stimulated Vasodilation and Skeletal Muscle Blood Flow Resulting in Systemic Insulin Resistance in Mice.
Md Torikul Islam, Jinjin Cai, Shanena Allen, Denisse G Moreno, Samuel I Bloom

Arterioscler Thromb Vasc Biol· May 2024

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Endothelial cell-specific reduction in mTOR ameliorates age-related arterial and metabolic dysfunction.
Md Torikul Islam, Shelby A Hall, Tavia Dutson, Samuel I Bloom, R Colton Bramwell

Aging Cell· February 2024

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Reduction of double-strand DNA break repair exacerbates vascular aging.
Samuel I Bloom, Jordan R Tucker, Daniel R Machin, Hossein Abdeahad, AdeLola O Adeyemo

Aging (Albany NY)· October 2023

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Glycocalyx-targeted therapy ameliorates age-related arterial dysfunction.
Daniel R Machin, Daniel W Trott, Venkateswara R Gogulamudi, Md Torikul Islam, Samuel I Bloom

Geroscience· August 2023

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Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impairments.
Samuel I Bloom, Yu Liu, Jordan R Tucker, Md Torikul Islam, Daniel R Machin

Aging Cell· August 2023

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Senolytics Reduce Endothelial Cell DNA Damage and Telomere Dysfunction Despite Reductions in Telomere Length.
Samuel I Bloom, Eric Tuday, Torikul Islam, Venkateswara R Gogulamudi, Lisa A Lesniewski

Aging Biol· June 2023

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Endothelial specific reduction in Arf6 impairs insulin-stimulated vasodilation and skeletal muscle blood flow resulting in systemic insulin resistance.
Md Torikul Islam, Jinjin Cai, Shanena Allen, Denisse G Moreno, Samuel I Bloom

bioRxiv· May 2023

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Mechanisms and consequences of endothelial cell senescence.
Samuel I Bloom, Md Torikul Islam, Lisa A Lesniewski, Anthony J Donato

Nat Rev Cardiol· January 2023

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Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions.
Samuel I Bloom, Jordan R Tucker, Jisok Lim, Tyler G Thomas, Gregory J Stoddard

Geroscience· December 2022

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Marijuana Use Associated with Decreased Mortality in Trauma Patients.
Samuel R Bloom, Areg Grigorian, Sebastian Schubl, Duraiyah Thangathurai, Catherine M Kuza

Am Surg· July 2022

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Hemostatic Responses to Multiple Bouts of Firefighting Activity: Female vs. Male Differences in a High Demand, High Performance Occupation.
Denise L Smith, Gavin P Horn, Steven J Petruzzello, Gregory G Freund, Samuel I Bloom

Int J Environ Res Public Health· February 2022

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T cells mediate cell non-autonomous arterial ageing in mice.
Daniel W Trott, Daniel R Machin, Tam T T Phuong, AdeLola O Adeyemo, Samuel I Bloom

J Physiol· August 2021

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Correction to "A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD-Dependent Enzymes".
Lik Hang Yuen, Srikanta Dana, Yu Liu, Samuel I Bloom, Ann-Gerd Thorsell

J Am Chem Soc· July 2021

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High-fat diet induced obesity and age influence the telomere shelterin complex and telomerase gene expression in mouse adipose tissue.
Samuel I Bloom, Andrei Tuluca, Stephen J Ives, Thomas H Reynolds

Physiol Rep· June 2020

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Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters.
Denise L Smith, Nicholas M G Friedman, Samuel I Bloom, William L Armero, Brandt D Pence

J Occup Environ Med· July 2019

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A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD-Dependent Enzymes.
Lik Hang Yuen, Srikanta Dana, Yu Liu, Samuel I Bloom, Ann-Gerd Thorsell

J Am Chem Soc· April 2019

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The role of senescence, telomere dysfunction and shelterin in vascular aging.
Yu Liu, Samuel I Bloom, Anthony J Donato

Microcirculation· February 2019

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Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress.
R Garrett Morgan, Ashley E Walker, Daniel W Trott, Daniel R Machin, Grant D Henson, Samuel I Bloom

J Mol Cell Cardiol· February 2019

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Implications of endothelial shear stress on systemic sclerosis vasculopathy and treatment.
Tracy M Frech, Daniel R Machin, Maureen A Murtaugh, Gregory J Stoddard, Samuel I Bloom

Clin Exp Rheumatol· January 2019

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Advanced age results in a diminished endothelial glycocalyx.
Daniel R Machin, Samuel I Bloom, Robert A Campbell, Tam T T Phuong, Phillip E Gates

Am J Physiol Heart Circ Physiol· September 2018

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