Publications by authors named "Samuel R Meier"

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Tumor suppressor collateral damage screens reveal mRNA homeostasis protein HBS1L as a novel vulnerability in ch9p21 driven FOCAD deleted cancer.
Hongxiang Zhang, Matthew R Tonini, Lauren Catherine M Martires, Helena N Jenkins, Charlotte B Pratt, Samuel R Meier

Biochim Biophys Acta Mol Cell Res· January 2026

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TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti-PD-1 Immunotherapy.
Leanne G Ahronian, Soumyadip Sahu, Minjie Zhang, Ayushi S Patel, Ke Geng, Samuel R Meier

Cancer Res· October 2025

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CRISPR Screens Identify POLB as a Synthetic Lethal Enhancer of PARP Inhibition Exclusively in BRCA-Mutated Tumors.
Katherine Lazarides, Justin L Engel, Michele Meseonznik, Tianshu Feng, Ashley H Choi, Samuel R Meier

Mol Cancer Ther· September 2025

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Comprehensively Testing the Function of Missense Variation in the Tumour Suppressor.
Daniel Zimmerman, Atina Cote, Warren van Loggerenberg, Marinella Gebbia, Nishka Kishore, Samuel R Meier

bioRxiv· July 2025

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Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency.
Antoine Simoneau, Charlotte B Pratt, Hsin-Jung Wu, Shreya S Rajeswaran, Charlotte Grace Comer, Samuel R Meier

Mol Cancer Ther· May 2025

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TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancers.
Kimberly J Briggs, Kevin M Cottrell, Matthew R Tonini, Alice Tsai, Minjie Zhang, Samuel R Meier

Transl Oncol· February 2025

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Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer.
Antoine Simoneau, Justin L Engel, Madhavi Bandi, Katherine Lazarides, Shangtao Liu, Samuel R Meier

Mol Cancer Ther· February 2023

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VRK1 Is a Synthetic-Lethal Target in VRK2-Deficient Glioblastoma.
Julie A Shields, Samuel R Meier, Madhavi Bandi, Erin E Mulkearns-Hubert, Nicole Hajdari

Cancer Res· November 2022

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Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate.
Abhishek A Chakraborty, Tuomas Laukka, Matti Myllykoski, Alison E Ringel, Matthew A Booker, Samuel R Meier

Science· March 2019

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