Publications by authors named "Samuli Auno"

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5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions.
Henri T Pätsi, Tommi P Kilpeläinen, Mikael Jumppanen, Johanna Uhari-Väänänen, Pieter Van Wielendaele, Samuli Auno

J Med Chem· April 2024

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Switching of hypertrophic signalling towards enhanced cardiomyocyte identity and maturity by a GATA4-targeted compound.
Lotta Pohjolainen, Sini M Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara

Stem Cell Res Ther· January 2024

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Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease.
Tommi P Kilpeläinen, Henri T Pätsi, Reinis Svarcbahs, Ulrika H Julku, Tony S Eteläinen, Samuli Auno

J Med Chem· June 2023

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Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model.
Tony S Eteläinen, Tommi P Kilpeläinen, Adele Ignatius, Samuli Auno, Francesca De Lorenzo

Neuropharmacology· November 2022

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Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy.
Hengjing Cui, Tommi Kilpeläinen, Lydia Zouzoula, Samuli Auno, Kalevi Trontti

J Cell Mol Med· October 2021

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2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors.
Henri T Pätsi, Tommi P Kilpeläinen, Samuli Auno, Pyry M J Dillemuth, Khaled Arja

ACS Med Chem Lett· October 2021

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Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators.
Mikael Jumppanen, Sini M Kinnunen, Mika J Välimäki, Virpi Talman, Samuli Auno

J Med Chem· September 2019

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Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.
S Tuuli Karhu, Mika J Välimäki, Mikael Jumppanen, Sini M Kinnunen, Lotta Pohjolainen, Samuli Auno

Arch Toxicol· September 2018

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Adenosine analogs bearing phosphate isosteres as human MDO1 ligands.
Yuezhou Zhang, Mikael Jumppanen, Mirko M Maksimainen, Samuli Auno, Zulfa Awol

Bioorg Med Chem· May 2018

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A Simple Method for Improving the Spatial Resolution in Infrared Laser Ablation Mass Spectrometry Imaging.
Juha-Pekka Hieta, Anu Vaikkinen, Samuli Auno, Heikki Räikkönen, Markus Haapala

J Am Soc Mass Spectrom· June 2017

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