Publications by authors named "Sangyeul Han"

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Identification of Tie2 as a sensor for reactive oxygen species and its therapeutic implication.
An Vuong Quynh Pham, Yongwoo Na, Gyeongseo Suk, Chansik Yang, So Min Kang, Sangyeul Han

Redox Biol· April 2025

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Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration.
Jaeryung Kim, Jang Ryul Park, Jeongwoon Choi, Intae Park, Yoonha Hwang, Sangyeul Han, Pilhan Kim

Sci Adv· February 2019

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Plastic roles of pericytes in the blood-retinal barrier.
Do Young Park, Junyeop Lee, Jaeryung Kim, Kangsan Kim, Seonpyo Hong, Sangyeul Han

Nat Commun· May 2017

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Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.
Jin-Sung Park, Il-Kug Kim, Sangyeul Han, Intae Park, Chan Kim

Cancer Cell· January 2017

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Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.
Jin-Sung Park, Il-Kug Kim, Sangyeul Han, Intae Park, Chan Kim

Cancer Cell· December 2016

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Calmodulin Mediates Ca2+-Dependent Inhibition of Tie2 Signaling and Acts as a Developmental Brake During Embryonic Angiogenesis.
Chansik Yang, Jiyeon Ohk, Ji Yeun Lee, Eun Jin Kim, Jiyoon Kim, Sangyeul Han

Arterioscler Thromb Vasc Biol· July 2016

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Amelioration of sepsis by TIE2 activation-induced vascular protection.
Sangyeul Han, Seung-Jun Lee, Kyung Eun Kim, Hyo Seon Lee, Nuri Oh, Hyung-Chan Kim, Pilhan Kim

Sci Transl Med· April 2016

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Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.
Shilpa Prabhakar, Xuan Zhang, June Goto, Sangyeul Han, Charles Lai

Neurobiol Dis· October 2015

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Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with α5β1 integrin.
Hyo Seon Lee, Seung Ja Oh, Kwang-Hoon Lee, Yoon-Sook Lee, Eun Ko, Hyung-chan Kim, Sangyeul Han

J Biol Chem· November 2014

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The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.
Sangyeul Han, Sun Kim, Samira Bahl, Lin Li, Clara F Burande

J Biol Chem· August 2012

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Regulation of mTOR complex 2 signaling in neurofibromatosis 2-deficient target cell types.
Marianne F James, Elizabeth Stivison, Roberta Beauchamp, Sangyeul Han, Hua Li

Mol Cancer Res· May 2012

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NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.
Marianne F James, Sangyeul Han, Carolyn Polizzano, Scott R Plotkin, Brendan D Manning

Mol Cell Biol· August 2009

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Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas.
Sangyeul Han, Carolyn Polizzano, Gunnlaugur P Nielsen, Francis J Hornicek, Andrew E Rosenberg

Clin Cancer Res· March 2009

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Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.
Dan Ehninger, Sangyeul Han, Carrie Shilyansky, Yu Zhou, Weidong Li

Nat Med· August 2008

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Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling.
Sangyeul Han, Rochelle M Witt, Túlio M Santos, Carolyn Polizzano, Bernardo L Sabatini

Cell Signal· June 2008

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Alternative splicing in protein associated with Myc (Pam) influences its binding to c-Myc.
Túlio M Santos, Sangyeul Han, Mark Bowser, Karen Sazani, Roberta L Beauchamp

J Neurosci Res· February 2006

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Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions.
Sangyeul Han, Túlio M Santos, Ana Puga, Jenn Roy, Elizabeth A Thiele

Cancer Res· February 2004

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Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex.
Vanishree Murthy, Sangyeul Han, Roberta L Beauchamp, Nicole Smith, Luciana A Haddad

J Biol Chem· January 2004

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