Publications by authors named "Sara Solbak"

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International Union of Basic and Clinical Pharmacology. CXX. γ-Hydroxybutyrate protein targets in the mammalian brain-beyond classic receptors.
Petrine Wellendorph, Stine Juul Gauger, Jens Velde Andersen, Birgitte Rahbek Kornum, Sara M O Solbak

Pharmacol Rev· July 2025

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Structure-Based Virtual Screening Identifies 2-Arylthiazole-4-Carboxylic Acids as a Novel Class of Nanomolar Affinity Ligands for the CaMKIIα Hub Domain.
Yongsong Tian, Vasileios Fougiaxis, Ludovica Stella Sirocchi, Stine Juul Gauger, Anne Sofie Gry Larsen, Sara M Ø Solbak

J Med Chem· February 2025

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Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity.
Dilip Narayanan, Anne Sofie G Larsen, Stine Juul Gauger, Ruth Adafia, Rikke Bartschick Hammershøi, Sara M Ø Solbak

Protein Sci· October 2024

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Author Correction: Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells.
Julie Zimmermann, Simon D van Haren, Joann Diray-Arce, Ignatius Ryan Adriawan, Katharina Wørzner, Sara M Ø Solbak

NPJ Vaccines· January 2024

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Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells.
Julie Zimmermann, Simon D van Haren, Joann Diray-Arce, Ignatius Ryan Adriawan, Katharina Wørzner, Sara M Ø Solbak

NPJ Vaccines· December 2023

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Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
Dilip Narayanan, Kim T Tran, Jakob S Pallesen, Sara M Ø Solbak, Yuting Qin

J Med Chem· November 2022

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Exploring the NCS-382 Scaffold for CaMKIIα Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain.
Yongsong Tian, Mohamed A Shehata, Stine Juul Gauger, Carolina Veronesi, Louise Hamborg, Sara M Ø Solbak

J Med Chem· November 2022

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Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain.
Yongsong Tian, Mohamed A Shehata, Stine Juul Gauger, Clarissa K L Ng, Sara Solbak

J Med Chem· May 2022

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GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain.
Ulrike Leurs, Anders B Klein, Ethan D McSpadden, Nane Griem-Krey, Sara M Ø Solbak

Proc Natl Acad Sci U S A· August 2021

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Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Jakob S Pallesen, Dilip Narayanan, Kim T Tran, Sara M Ø Solbak, Giuseppe Marseglia

J Med Chem· April 2021

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Identification of Novel Fragments Binding to the PDZ1-2 Domain of PSD-95.
Jie Zang, Fei Ye, Sara M Ø Solbak, Lars J Høj, Mingjie Zhang

ChemMedChem· March 2021

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The dynamics of linear polyubiquitin.
Alexander Jussupow, Ana C Messias, Ralf Stehle, Arie Geerlof, Sara M Ø Solbak

Sci Adv· October 2020

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Fibrin fragment E potentiates TGF-β-induced myofibroblast activation and recruitment.
Peder Öhman Fuchs, Carlemi Calitz, Nataša Pavlović, François Binet, Sara Marie Øie Solbak

Cell Signal· August 2020

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Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.
Sara Marie Øie Solbak, Jie Zang, Dilip Narayanan, Lars Jakobsen Høj, Saskia Bucciarelli

J Med Chem· February 2020

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A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
Kim T Tran, Jakob S Pallesen, Sara M Ø Solbak, Dilip Narayanan, Amina Baig

J Med Chem· September 2019

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Molecular architecture of the Jumonji C family histone demethylase KDM5B.
Jerzy Dorosz, Line Hyltoft Kristensen, Nanda G Aduri, Osman Mirza, Rikke Lousen, Sara Marie Øie Solbak

Sci Rep· March 2019

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Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition.
Sara M Ø Solbak, Eldar Abdurakhmanov, Anni Vedeler, U Helena Danielson

Virol J· December 2017

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Insights from engineering the Affibody-Fc interaction with a computational-experimental method.
Masoumeh Nosrati, Sara Solbak, Olle Nordesjö, Mikael Nissbeck, Daniel F A R Dourado

Protein Eng Des Sel· September 2017

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Mutation of the highly conserved Ser-40 of the HIV-1 p6 gag protein to Phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of Gag.
Friedrich Hahn, Christian Setz, Melanie Friedrich, Pia Rauch, Sara Marie Solbak

Viruses· October 2014

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HIV-1 p6 - a structured to flexible multifunctional membrane-interacting protein.
Sara Marie Øie Solbak, Tove Ragna Reksten, Friedrich Hahn, Victor Wray, Petra Henklein

Biochim Biophys Acta· February 2013

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Influenza A virus protein PB1-F2 from different strains shows distinct structural signatures.
Sara M Ø Solbak, Alok Sharma, Karsten Bruns, René Röder, David Mitzner

Biochim Biophys Acta· February 2013

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Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-α binding.
Rike Webel, Sara M Ø Solbak, Christian Held, Jens Milbradt, Andrea Groß

J Gen Virol· August 2012

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HIV-1 p6-Another viral interaction partner to the host cellular protein cyclophilin A.
Sara M Ø Solbak, Tove R Reksten, Rene Röder, Victor Wray, Ole Horvli

Biochim Biophys Acta· April 2012

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The host-pathogen interaction of human cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains.
Sara M Ø Solbak, Victor Wray, Ole Horvli, Arnt J Raae, Marte I Flydal

BMC Struct Biol· December 2011

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Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly.
Jörg Votteler, Liane Neumann, Sabine Hahn, Friedrich Hahn, Pia Rauch, Sara M Ø Solbak

Retrovirology· February 2011

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