Publications by authors named "Jens Milbradt"

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[Promoting vaccination prevention in Germany across federal states with a focus on European goals: the national immunization steering group (NaLI)].
Jens Milbradt, Maria-Sabine Ludwig

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz· April 2025

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Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation.
Sigrun Häge, Eric Sonntag, Adriana Svrlanska, Eva Maria Borst, Anne-Charlotte Stilp, Jens Milbradt

Viruses· January 2021

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The peptidyl-prolyl cis/trans isomerase Pin1 interacts with three early regulatory proteins of human cytomegalovirus.
Martin Schütz, Marco Thomas, Christina Wangen, Sabrina Wagner, Luisa Rauschert, Jens Milbradt

Virus Res· August 2020

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Differential upregulation of host cell protein kinases by the replication of α-, β- and γ-herpesviruses provides a signature of virus-specific signalling.
Manfred Marschall, Hanife Strojan, Richard Kiener, Christina Wangen, Eric Sonntag, Jens Milbradt

J Gen Virol· March 2020

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Phosphosite Analysis of the Cytomegaloviral mRNA Export Factor pUL69 Reveals Serines with Critical Importance for Recruitment of Cellular Proteins Pin1 and UAP56/URH49.
Marco Thomas, Regina Müller, Georg Horn, Boris Bogdanow, Koshi Imami, Jens Milbradt

J Virol· March 2020

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Patterns of Autologous and Nonautologous Interactions Between Core Nuclear Egress Complex (NEC) Proteins of α-, β- and γ-Herpesviruses.
Sigrun Häge, Eric Sonntag, Eva Maria Borst, Pierre Tannig, Lisa Seyler, Jens Milbradt

Viruses· March 2020

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Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97.
Ramona Businger, Janina Deutschmann, Iris Gruska, Jens Milbradt, Lüder Wiebusch

Nat Microbiol· December 2019

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A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1.
Janina Deutschmann, Andrea Schneider, Iris Gruska, Barbara Vetter, Dominique Thomas, Jens Milbradt

Nat Microbiol· December 2019

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Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.
Stuart T Hamilton, Corina Hutterer, Ece Egilmezer, Mirjam Steingruber, Jens Milbradt

Placenta· December 2018

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Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L.
Myoung Kyu Lee, Ye Ji Kim, Young-Eui Kim, Tae-Hee Han, Jens Milbradt

J Virol· August 2018

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Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97.
Jens Milbradt, Eric Sonntag, Sabrina Wagner, Hanife Strojan, Christina Wangen

Viruses· January 2018

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Protein kinases responsible for the phosphorylation of the nuclear egress core complex of human cytomegalovirus.
Eric Sonntag, Jens Milbradt, Adriana Svrlanska, Hanife Strojan, Sigrun Häge

J Gen Virol· October 2017

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Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity.
Corina Hutterer, Jens Milbradt, Stuart Hamilton, Mirko Zaja, Johann Leban

Antiviral Res· July 2017

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The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids.
Manfred Marschall, Yves A Muller, Benedikt Diewald, Heinrich Sticht, Jens Milbradt

Rev Med Virol· July 2017

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Erratum to Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components.
Eric Sonntag, Stuart T Hamilton, Hanife Bahsi, Sabrina Wagner, Stipan Jonjic, Jens Milbradt

J Gen Virol· September 2016

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The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress.
Jens Milbradt, Corina Hutterer, Hanife Bahsi, Sabrina Wagner, Eric Sonntag

PLoS Pathog· August 2016

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Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components.
Eric Sonntag, Stuart T Hamilton, Hanife Bahsi, Sabrina Wagner, Stipan Jonjic, Jens Milbradt

J Gen Virol· July 2016

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Human Cytomegalovirus Nuclear Egress Proteins Ectopically Expressed in the Heterologous Environment of Plant Cells are Strictly Targeted to the Nuclear Envelope.
Christian E Lamm, Katrin Link, Sabrina Wagner, Jens Milbradt, Manfred Marschall

Viruses· March 2016

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New insight into the phosphorylation-regulated intranuclear localization of human cytomegalovirus pUL69 mediated by cyclin-dependent kinases (CDKs) and viral CDK orthologue pUL97.
Laura Graf, Sabine Feichtinger, Zin Naing, Corina Hutterer, Jens Milbradt

J Gen Virol· January 2016

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The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65.
Corina Hutterer, Ina Niemann, Jens Milbradt, Tony Fröhlich, Christoph Reiter

Antiviral Res· December 2015

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Crystal Structure of the Human Cytomegalovirus pUL50-pUL53 Core Nuclear Egress Complex Provides Insight into a Unique Assembly Scaffold for Virus-Host Protein Interactions.
Sascha A Walzer, Claudia Egerer-Sieber, Heinrich Sticht, Madhumati Sevvana, Katharina Hohl, Jens Milbradt

J Biol Chem· November 2015

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A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations.
Corina Hutterer, Jan Eickhoff, Jens Milbradt, Klaus Korn, Isabel Zeitträger

Antimicrob Agents Chemother· April 2015

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Human cytomegalovirus replication is strictly inhibited by siRNAs targeting UL54, UL97 or UL122/123 gene transcripts.
Stuart T Hamilton, Jens Milbradt, Manfred Marschall, William D Rawlinson

PLoS One· January 2015

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Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus.
Jens Milbradt, Alexandra Kraut, Corina Hutterer, Eric Sonntag, Cathrin Schmeiser

Mol Cell Proteomics· August 2014

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The cytomegalovirus egress proteins pUL50 and pUL53 are translocated to the nuclear envelope through two distinct modes of nuclear import.
Cathrin Schmeiser, Eva Borst, Heinrich Sticht, Manfred Marschall, Jens Milbradt

J Gen Virol· September 2013

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