Publications by authors named "Sarah Northall"

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Use of Direct-to-Biology Strategies for the Discovery of 2'-Deoxynucleoside 5'-Monophosphate N-Glycosidase (DNPH1) PROTACs.
Niall A Anderson, Bernard Barlaam, Argyrides Argyrou, Peter C Astles, Hanna Bruss, Sarah Northall

J Med Chem· November 2025

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Discovery and Optimization of a Non-Nucleoside-Based Series of Inhibitors of 2'-Deoxynucleoside 5'-Monophosphate Glycosidase (DNPH1).
Bernard Barlaam, Luz Alonso-Crisostomo, Niall A Anderson, Argyrides Argyrou, Peter C Astles, Sarah Northall

J Med Chem· November 2025

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Focused Structure-Based Virtual Screening Identifies Novel Inhibitors of SOS1.
Silvia Bonomo, Floriane Gibault, Sharan K Bagal, J Henry Blackwell, Jason Breed, Sarah Northall

ACS Med Chem Lett· October 2025

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DNA binding and bridging by human CtIP in the healthy and diseased states.
Shreya Lokanathan Balaji, Sara De Bragança, Francisco Balaguer-Pérez, Sarah Northall, Oliver John Wilkinson

Nucleic Acids Res· August 2024

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Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches.
Luca Carlino, Peter C Astles, Bryony Ackroyd, Afshan Ahmed, Christina Chan, Sarah Northall

J Med Chem· June 2024

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Breakers and amplifiers in chromatin circuitry: acetylation and ubiquitination control the heterochromatin machinery.
Luke T Bailey, Sarah J Northall, Thomas Schalch

Curr Opin Struct Biol· December 2021

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SUV39 SET domains mediate crosstalk of heterochromatic histone marks.
Alessandro Stirpe, Nora Guidotti, Sarah J Northall, Sinan Kilic, Alexandre Hainard

Elife· September 2021

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The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core.
Tabitha Jenkins, Sarah J Northall, Denis Ptchelkine, Rebecca Lever, Andrew Cubbon

NAR Cancer· March 2021

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CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair.
Oliver J Wilkinson, Alejandro Martín-González, Haejoo Kang, Sarah J Northall, Dale B Wigley

Elife· January 2019

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DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain.
Sarah J Northall, Ryan Buckley, Nathan Jones, J Carlos Penedo, Panos Soultanas

DNA Repair (Amst)· September 2017

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Remodeling and Control of Homologous Recombination by DNA Helicases and Translocases that Target Recombinases and Synapsis.
Sarah J Northall, Ivana Ivančić-Baće, Panos Soultanas, Edward L Bolt

Genes (Basel)· August 2016

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