Publications by authors named "Sarah Perrett"

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Dissecting the Molecular Determinants of α-synuclein Phase Separation and Condensate Aging: The Pivotal Role of β-Sheet-Rich Motifs.
Yiming Tang, Jitao Wen, Zhongyuan Yang, Yifei Yao, Shaoshuai He, Sarah Perrett

Adv Sci (Weinh)· November 2025

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Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior.
Jitao Wen, Yiming Tang, Tomas Sneideris, Hannes Ausserwöger, Liu Hong, Sarah Perrett

JACS Au· September 2025

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Exploring the effects of macromolecular crowding on the conformation and NuMA binding of 4.1G-CTD.
Shi Yu, Ming Yang, Sarah Perrett, Si Wu, Zhijun Liu

Phys Chem Chem Phys· August 2025

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Single-molecule study of the dynamics of the molecular chaperone Hsp70 during the functional cycle.
Huimin Hu, Ming Yang, Sarah Perrett, Si Wu

Biochem Soc Trans· April 2025

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Interaction between huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins.
Hong Zhang, Si Wu, Laura S Itzhaki, Sarah Perrett

Protein Sci· December 2023

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Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology.
Yongqi Huang, Jitao Wen, Lisa-Marie Ramirez, Eymen Gümüşdil, Pravin Pokhrel, Sarah Perrett

Nat Commun· September 2023

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Exploration of the cysteine reactivity of human inducible Hsp70 and cognate Hsc70.
Zhouping Hong, Weibin Gong, Jie Yang, Sainan Li, Zhenyan Liu, Sarah Perrett

J Biol Chem· January 2023

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Reversible Redox-Dependent Conformational Switch of the C-Terminal α-Helical Lid of Human Hsp70 Observed by In-Cell NMR.
Qihui Liang, Yiying Zhang, Hong Zhang, Si Wu, Weibin Gong, Sarah Perrett

ACS Chem Biol· January 2023

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Effect of evolution of the C-terminal region on chaperone activity of Hsp70.
Hong Zhang, Huimin Hu, Si Wu, Sarah Perrett

Protein Sci· January 2023

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Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation.
Si Wu, Jitao Wen, Sarah Perrett

Essays Biochem· December 2022

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Correction: Structural basis for the DNA-binding activity of human ARID4B Tudor domain.
Jie Ren, Hongwei Yao, Wanhui Hu, Sarah Perrett, Weibin Gong

J Biol Chem· October 2022

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Correction to: Resonance assignments for the tandem PWWP-ARID domains of human RBBP1.
Weibin Gong, Xingzhe Yao, Qihui Liang, Yufeng Tong, Sarah Perrett

Biomol NMR Assign· April 2022

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PES derivative PESA is a potent tool to globally profile cellular targets of PES.
Jie Yang, Zhenyan Liu, Sarah Perrett, Hong Zhang, Zhengying Pan

Bioorg Med Chem Lett· March 2022

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Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis.
Qiong-Qiong Yao, Jitao Wen, Sarah Perrett, Si Wu

Nanoscale· March 2022

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Hsp70 in Redox Homeostasis.
Hong Zhang, Weibin Gong, Si Wu, Sarah Perrett

Cells· February 2022

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Structural Insight into Chromatin Recognition by Multiple Domains of the Tumor Suppressor RBBP1.
Weibin Gong, Qihui Liang, Yufeng Tong, Sarah Perrett, Yingang Feng

J Mol Biol· October 2021

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Structural basis for the DNA-binding activity of human ARID4B Tudor domain.
Jie Ren, Hongwei Yao, Wanhui Hu, Sarah Perrett, Weibin Gong

J Biol Chem· August 2021

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PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain.
Jie Yang, Weibin Gong, Si Wu, Hong Zhang, Sarah Perrett

J Biol Chem· August 2021

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Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation.
Jitao Wen, Liu Hong, Georg Krainer, Qiong-Qiong Yao, Tuomas P J Knowles, Sarah Perrett

J Am Chem Soc· August 2021

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Mutational analysis of the Hsp70 substrate-binding domain: Correlating molecular-level changes with in vivo function.
Linan Xu, Hong Zhang, Daragh D Cuskelly, Sean Doyle, Sarah Perrett

Mol Microbiol· June 2021

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Studying protein folding in health and disease using biophysical approaches.
Hong Zhang, Weibin Gong, Si Wu, Sarah Perrett

Emerg Top Life Sci· May 2021

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Single Molecule Characterization of Amyloid Oligomers.
Jie Yang, Sarah Perrett, Si Wu

Molecules· February 2021

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Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules.
Xingzhe Yao, Chao Chen, Yefei Wang, Sheng Dong, Ya-Jun Liu, Sarah Perrett

Sci Adv· October 2020

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Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils.
Jie Yang, Alexander J Dear, Qiong-Qiong Yao, Zhenyan Liu, Christopher M Dobson, Sarah Perrett

Nanoscale· September 2020

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Kinetic diversity of amyloid oligomers.
Alexander J Dear, Thomas C T Michaels, Georg Meisl, David Klenerman, Si Wu, Sarah Perrett

Proc Natl Acad Sci U S A· June 2020

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