Publications by authors named "Sarah Shefer"

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Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis.
Akira Honda, Gerald Salen, Yasushi Matsuzaki, Ashok K Batta, Guorong Xu, Sarah Shefer

J Lipid Res· February 2005

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Role of CYP27A in cholesterol and bile acid metabolism.
Sandrine Dubrac, Steven R Lear, Meena Ananthanarayanan, Natarajan Balasubramaniyan, Jaya Bollineni, Sarah Shefer

J Lipid Res· January 2005

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Effect of high plant sterol-enriched diet and cholesterol absorption inhibitor, SCH 58235, on plant sterol absorption and plasma concentrations in hypercholesterolemic wild-type Kyoto rats.
Ashok K Batta, Guorong Xu, Jaya S Bollineni, Sarah Shefer, Gerald Salen

Metabolism· January 2005

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Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase.
Hai Li, Guorong Xu, Quan Shang, Luxing Pan, Sarah Shefer

Metabolism· July 2004

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Dietary cholesterol stimulates CYP7A1 in rats because farnesoid X receptor is not activated.
Guorong Xu, Lu-Xing Pan, Hai Li, Quan Shang, Akira Honda, Sarah Shefer

Am J Physiol Gastrointest Liver Physiol· May 2004

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A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol.
Eric L Klett, Kangmo Lu, Astrid Kosters, Edwin Vink, Mi-Hye Lee, Sarah Shefer

BMC Med· March 2004

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Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity.
Michaela Tiemann, Zhihua Han, Raymond Soccio, Jaya Bollineni, Sarah Shefer

Proc Natl Acad Sci U S A· February 2004

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Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits.
Akira Honda, Tadashi Yoshida, Guorong Xu, Yasushi Matsuzaki, Sugano Fukushima, Sarah Shefer

Metabolism· January 2004

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FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits.
Guorong Xu, Hai Li, Lu-Xing Pan, Quan Shang, Akira Honda, Sarah Shefer

J Lipid Res· October 2003

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Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol.
Ephraim Sehayek, Rong Wang, Jennie G Ono, Vadim S Zinchuk, Elizabeth M Duncan, Sarah Shefer

J Lipid Res· September 2003

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Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice.
Sandra K Erickson, Steven R Lear, Sean Deane, Sandrine Dubrac, Sandra L Huling, Sarah Shefer

J Lipid Res· May 2003

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Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits.
Guorong Xu, Lu-Xing Pan, Hai Li, Barry M Forman, Sandra K Erickson, Sarah Shefer

J Biol Chem· December 2002

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Analysis of the effect of intestinal resection on rat ileal bile Acid transporter expression and on bile Acid and cholesterol homeostasis.
Namir Al-Ansari, Guorong Xu, Katie Kollman-Bauerly, Chris Coppola, Sarah Shefer

Pediatr Res· August 2002

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Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.
Clive R Pullinger, Celeste Eng, Gerald Salen, Sarah Shefer, Ashok K Batta

J Clin Invest· July 2002

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Removal of the bile acid pool upregulates cholesterol 7alpha-hydroxylase by deactivating FXR in rabbits.
Guorong Xu, Lu-xing Pan, Sandra K Erickson, Barry M Forman, Benjamin L Shneider, Sarah Shefer

J Lipid Res· January 2002

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