Publications by authors named "Scott Plafker"

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Sulforaphane acutely activates multiple starvation response pathways.
Kendra S Plafker, Constantin Georgescu, Nathan Pezant, Atul Pranay, Scott M Plafker

Front Nutr· January 2025

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Age- and sex- divergent translatomic responses of the mouse retinal pigmented epithelium.
Ana J Chucair-Elliott, Sarah R Ocañas, Kevin Pham, Adeline Machalinski, Scott Plafker

Neurobiol Aging· August 2024

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Editorial: Diet and multiple sclerosis.
Tyler J Titcomb, Barbara S Giesser, Scott M Plafker, Ilana B Katz Sand, Terry L Wahls

Front Neurol· December 2023

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Overview of diet and autoimmune demyelinating optic neuritis: a narrative review.
Scott M Plafker, Tyler Titcomb, Katarzyna Zyla-Jackson, Aneta Kolakowska, Terry Wahls

Immunometabolism (Cobham)· April 2023

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Dietary protection against the visual and motor deficits induced by experimental autoimmune encephalomyelitis.
Katarzyna Zyla-Jackson, Dorothy A Walton, Kendra S Plafker, Susan Kovats, Constantin Georgescu, Scott M Plafker

Front Neurol· March 2023

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Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis.
Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M Piekarz, Sabira Mohammed, Scott Plafker

Redox Biol· February 2023

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Sulforaphane recovers cone function in an Nrf2-dependent manner in middle-aged mice undergoing RPE oxidative stress.
Xiaoping Qi, Dorothy A Walton, Kendra S Plafker, Michael E Boulton, Scott M Plafker

Mol Vis· November 2022

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Dimethyl fumarate mitigates optic neuritis.
Katarzyna Zyla, Chelsea M Larabee, Constantin Georgescu, Chelsea Berkley, Tania Reyna, Scott M Plafker

Mol Vis· April 2020

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Clinically-approved CFTR modulators rescue Nrf2 dysfunction in cystic fibrosis airway epithelia.
Dana C Borcherding, Matthew E Siefert, Songbai Lin, John Brewington, Hesham Sadek, Scott M Plafker

J Clin Invest· May 2019

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Regulation of Nrf2 by X Box-Binding Protein 1 in Retinal Pigment Epithelium.
Chen Chen, Yimin Zhong, Joshua J Wang, Qiang Yu, Kendra Plafker, Scott Plafker

Front Genet· December 2018

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Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence.
Kendra S Plafker, Katarzyna Zyla, William Berry, Scott M Plafker

Redox Biol· July 2018

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Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis.
Chelsea M Larabee, Shruti Desai, Agnieshka Agasing, Constantin Georgescu, Jonathan D Wren, Scott M Plafker

Mol Vis· January 2018

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A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.
Gary B O'Mealey, Kendra S Plafker, William L Berry, Ralf Janknecht, Jefferson Y Chan, Scott M Plafker

J Cell Sci· October 2017

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Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.
Gary B O'Mealey, William L Berry, Scott M Plafker

Redox Biol· April 2017

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The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.
Muhan Chen, Dawid G Nowak, Navneet Narula, Brian Robinson, Kaitlin Watrud, Kendra S Plafker, Scott M Plafker

J Cell Biol· March 2017

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Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice.
Chelsea M Larabee, Yang Hu, Shruti Desai, Constantin Georgescu, Jonathan D Wren, Scott M Plafker

Mol Vis· November 2016

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Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration.
Mandy L Lambros, Scott M Plafker

Adv Exp Med Biol· April 2016

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Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons.
Chelsea M Larabee, Constantin Georgescu, Jonathan D Wren, Scott M Plafker

BMC Neurosci· November 2015

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OKN-007 decreases free radical levels in a preclinical F98 rat glioma model.
Patricia Coutinho de Souza, Nataliya Smith, Oluwatomisin Atolagbe, Jadith Ziegler, Charity Njoku, Scott M Plafker

Free Radic Biol Med· October 2015

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The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.
Kendra S Plafker, Scott M Plafker

Mol Biol Cell· January 2015

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The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin.
Linda Nguyen, Kendra S Plafker, Andrew Starnes, Matt Cook, Rachel E Klevit, Scott M Plafker

Biochemistry· June 2014

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Mechanisms for countering oxidative stress and damage in retinal pigment epithelium.
Scott M Plafker, Gary B O'Mealey, Luke I Szweda

Int Rev Cell Mol Biol· April 2013

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High dietary fat selectively increases catalase expression within cardiac mitochondria.
Paul M Rindler, Scott M Plafker, Luke I Szweda, Michael Kinter

J Biol Chem· January 2013

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Interaction with CREB binding protein modulates the activities of Nrf2 and NF-κB in cystic fibrosis airway epithelial cells.
Assem G Ziady, Andrew Sokolow, Samuel Shank, Deborah Corey, Ross Myers, Scott Plafker

Am J Physiol Lung Cell Mol Physiol· June 2012

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Expression and distribution of the class III ubiquitin-conjugating enzymes in the retina.
Saima Mirza, Kendra S Plafker, Christopher Aston, Scott M Plafker

Mol Vis· November 2010

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