Publications by authors named "Sean Downing"

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2023 White Paper on Recent Issues in Bioanalysis: EU IVDR 2017/746 Implementation/Impact, IVD/CDx/CLIA Approved Assays, High Dimensional Cytometry, Multiplexing Technologies, LBA Tissue Analysis, Vaccine Study Endpoints, Cell-Based Assays for Biomarkers, Cell Therapy and Vaccines ( - Recommendations on Development & Validation of Biomarkers, IVD, CDx, Cell-Based, Flow Cytometry, Ligand-Binding and Enzyme Assays; Advanced Critical Reagents Strategies).
Olga Kholmanskikh, Yow-Ming Wang, Sarah Hersey, Meenu Wadhwa, Katherine Block, Sean Downing

Bioanalysis· June 2024

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2022 White Paper on Recent Issues in Bioanalysis: FDA Draft Guidance on Immunogenicity Information in Prescription Drug Labeling, LNP & Viral Vectors Therapeutics/Vaccines Immunogenicity, Prolongation Effect, ADA Affinity, Risk-based Approaches, NGS, qPCR, ddPCR Assays ( - Recommendations on Gene Therapy, Cell Therapy, Vaccines Immunogenicity & Technologies; Immunogenicity & Risk Assessment of Biotherapeutics and Novel Modalities; NAb Assays Integrated Approach).
Luying Pan, Johanna Mora, Karl Walravens, Leslie Wagner, Shirley Hopper, Sean Downing

Bioanalysis· July 2023

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The InSituPlex Staining Method for Multiplexed Immunofluorescence Cell Phenotyping and Spatial Profiling of Tumor FFPE Samples.
Mael Manesse, Katir K Patel, Mark Bobrow, Sean R Downing

Methods Mol Biol· November 2020

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Colchicine, Aspirin, and Montelukast - A Case of Successful Combined Pharmacotherapy for Adult Multisystem Inflammatory Syndrome in COVID-19.
Sean Downing, Vivek Chauhan, Irshad H Chaudry, Sagar Galwankar, Pushpa Sharma

J Glob Infect Dis· November 2020

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Response of an ERBB2-mutated inflammatory breast carcinoma to human epidermal growth factor receptor 2-targeted therapy.
Siraj M Ali, R Katherine Alpaugh, Sean R Downing, Philip J Stephens, Jian Q Yu

J Clin Oncol· September 2014

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Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy.
Jeffrey S Ross, Kai Wang, Rami N Al-Rohil, Tipu Nazeer, Christine E Sheehan, Sean R Downing

Mod Pathol· February 2014

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Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies.
Jeffrey S Ross, Kai Wang, Janna V Rand, Christine E Sheehan, Timothy A Jennings, Sean R Downing

Am J Surg Pathol· February 2014

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A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma.
Jeffrey S Ross, Kai Wang, Laurie M Gay, Rami N Al-Rohil, Tipu Nazeer, Sean R Downing

Clin Cancer Res· January 2014

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Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing.
Garrett M Frampton, Alex Fichtenholtz, Geoff A Otto, Kai Wang, Sean R Downing

Nat Biotechnol· November 2013

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Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity.
Himisha Beltran, Roman Yelensky, Garrett M Frampton, Kyung Park, Sean R Downing

Eur Urol· May 2013

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Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations.
Jeffrey S Ross, Kai Wang, Christine E Sheehan, Ann B Boguniewicz, Geoff Otto, Sean R Downing

Clin Cancer Res· May 2013

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Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics.
Erica L Mayer, Steven J Isakoff, Giannoula Klement, Sean R Downing, Wendy Y Chen

Breast Cancer Res Treat· November 2012

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Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer.
Oddbjørn Straume, Takeshi Shimamura, Michael J G Lampa, Julian Carretero, Anne M Øyan, Sean R Downing

Proc Natl Acad Sci U S A· May 2012

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Isolation and proteomic analysis of platelets by SELDI-TOF MS.
Sean R Downing, Giannoula L Klement

Methods Mol Biol· March 2012

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Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.
Doron Lipson, Marzia Capelletti, Roman Yelensky, Geoff Otto, Alex Parker, Sean R Downing

Nat Med· February 2012

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Simultaneous and exact interval estimates for the contrast of two groups based on an extremely high dimensional variable: application to mass spec data.
Yuhyun Park, Sean R Downing, Dohyun Kim, William C Hahn, Cheng Li

Bioinformatics· June 2007

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Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer.
Sean R Downing, Kristen T Hennessy, Miyako Abe, Judith Manola, Daniel J George

Clin Prostate Cancer· December 2003

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Elevated levels of prostate-specific antigen (PSA) in prostate cancer cells expressing mutant p53 is associated with tumor metastasis.
Sean Downing, Clare Bumak, Sheri Nixdorf, Kim Ow, Pamela Russell

Mol Carcinog· November 2003

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Alterations of p53 are common in early stage prostate cancer.
Sean R Downing, Pamela J Russell, Paul Jackson

Can J Urol· August 2003

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