Publications by authors named "Sean Irwin"

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Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
Mackenzie J Parker, Hyelee Lee, Shihua Yao, Sean Irwin, Sunil Hwang

Biochemistry· July 2023

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Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists.
Sean Irwin, Craig Karr, Craig Furman, Jennifer Tsai, Patricia Gee

J Biol Chem· November 2022

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Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer.
Craig Furman, Xiaoling Puyang, Zhaojie Zhang, Zhenhua J Wu, Deepti Banka, Sean Irwin

Mol Cancer Ther· June 2022

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Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3.
Ryan A Brawn, Andrew Cook, Kiyoyuki Omoto, Jiyuan Ke, Craig Karr, Sean Irwin

ACS Med Chem Lett· January 2021

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Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Manav Korpal, Xiaoling Puyang, Zhenhua Jeremy Wu, Roland Seiler, Craig Furman, Sean Irwin

Nat Commun· June 2019

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Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα and ERα Breast Cancer.
Xiaoling Puyang, Craig Furman, Guo Zhu Zheng, Zhenhua J Wu, Deepti Banka, Sean Irwin

Cancer Discov· September 2018

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The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.
Lorenzo I Finci, Xiaofeng Zhang, Xiuliang Huang, Qiang Zhou, Jennifer Tsai, Sean Irwin

Genes Dev· February 2018

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Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Manav Korpal, Xiaoling Puyang, Zhenhua Jeremy Wu, Roland Seiler, Craig Furman, Sean Irwin

Nat Commun· July 2017

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