Publications by authors named "Craig Karr"

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Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists.
Sean Irwin, Craig Karr, Craig Furman, Jennifer Tsai, Patricia Gee

J Biol Chem· November 2022

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Combined inhibition of FGFR4 and VEGFR signaling enhances efficacy in FGF19 driven hepatocellular carcinoma.
Xuesong Zhao, Jaya Julie Joshi, Daniel Aird, Craig Karr, Kun Yu

Am J Cancer Res· June 2022

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Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3.
Ryan A Brawn, Andrew Cook, Kiyoyuki Omoto, Jiyuan Ke, Craig Karr

ACS Med Chem Lett· January 2021

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Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.
Daniel Aird, Teng Teng, Chia-Ling Huang, Ermira Pazolli, Deepti Banka, Craig Karr

Nat Commun· January 2019

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Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα and ERα Breast Cancer.
Xiaoling Puyang, Craig Furman, Guo Zhu Zheng, Zhenhua J Wu, Deepti Banka, Craig Karr

Cancer Discov· September 2018

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H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.
Michael Seiler, Akihide Yoshimi, Rachel Darman, Betty Chan, Gregg Keaney, Craig Karr

Nat Med· May 2018

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The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.
Lorenzo I Finci, Xiaofeng Zhang, Xiuliang Huang, Qiang Zhou, Jennifer Tsai, Craig Karr

Genes Dev· February 2018

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H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.
Jaya Julie Joshi, Heather Coffey, Erik Corcoran, Jennifer Tsai, Chia-Ling Huang, Craig Karr

Cancer Res· December 2017

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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Teng Teng, Jennifer Hc Tsai, Xiaoling Puyang, Michael Seiler, Shouyong Peng, Craig Karr

Nat Commun· May 2017

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Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell line.
Kenzo Arai, Silvia Buonamici, Betty Chan, Laura Corson, Atsushi Endo, Craig Karr

Org Lett· November 2014

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Cyst wall synthase: N-acetylgalactosaminyltransferase activity is induced to form the novel N-acetylgalactosamine polysaccharide in the Giardia cyst wall.
Craig D Karr, Edward L Jarroll

Microbiology (Reading)· May 2004

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The Giardia intestinalis filamentous cyst wall contains a novel beta(1-3)-N-acetyl-D-galactosamine polymer: a structural and conformational study.
Gerrit J Gerwig, J Albert van Kuik, Bas R Leeflang, Johannis P Kamerling, Johannes F G Vliegenthart, Craig D Karr

Glycobiology· August 2002

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