Publications by authors named "Sean R Connell"

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A binding site for the antibiotic GE81112 in the ribosomal mRNA channel.
Andreas Schedlbauer, Xu Han, Wouter van Bakel, Tatsuya Kaminishi, Borja Ochoa-Lizarralde, Sean R Connell

mBio· November 2025

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Molecular basis of Fab-dependent IgA antibody recognition by gut-bacterial metallopeptidases.
María Ángeles Márquez-Moñino, Ana Martínez Gascueña, Tala Azzam, Andrea Persson, Aitor Manzanares-Gomez, Sean R Connell

EMBO J· September 2025

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A binding site for the antibiotic GE81112 in the ribosomal mRNA channel.
Andreas Schedlbauer, Xu Han, Wouter van Bakel, Tatsuya Kaminishi, Borja Ochoa-Lizarralde, Sean R Connell

bioRxiv· September 2024

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CryoEM reveals that ribosomes in microsporidian spores are locked in a dimeric hibernating state.
Mathew McLaren, Rebecca Conners, Michail N Isupov, Patricia Gil-Díez, Lavinia Gambelli, Sean R Connell

Nat Microbiol· October 2023

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CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from reveals key conformations for activity regulation and function.
Xu Han, Cecilia D'Angelo, Ainara Otamendi, Javier O Cifuente, Elisa de Astigarraga, Sean R Connell

mBio· August 2023

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Disruption of Dcp1 leads to a Dcp2-dependent aberrant ribosome profiles in Aspergillus nidulans.
Izwan Bharudin, Mark X Caddick, Sean R Connell, Matthew T F Lamaudière, Igor Y Morozov

Mol Microbiol· May 2023

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Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.
Soledad Stagnoli, Francesca Peccati, Sean R Connell, Ane Martinez-Castillo, Diego Charro

Front Microbiol· April 2022

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A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit.
Andreas Schedlbauer, Idoia Iturrioz, Borja Ochoa-Lizarralde, Tammo Diercks, Jorge Pedro López-Alonso, Sean R Connell

Sci Adv· June 2021

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Histone mRNA is subject to 3' uridylation and re-adenylation in Aspergillus nidulans.
Amir Mossanen-Parsi, Daniele Parisi, Natasha Browne-Marke, Izwan Bharudin, Sean R Connell

Mol Microbiol· February 2021

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Backbone and sidechain NMR assignments for the ribosome maturation factor RimP from Escherichia coli.
Andreas Schedlbauer, Borja Ochoa-Lizarralde, Idoia Iturrioz, Retina Çapuni, Tammo Diercks, Sean R Connell

Biomol NMR Assign· October 2020

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Backbone and sidechain NMR assignments for the ribosome maturation factor RbfA from Escherichia coli.
Andreas Schedlbauer, Idoia Iturrioz, Borja Ochoa-Lizarralde, Retina Çapuni, Xu Han, Sean R Connell

Biomol NMR Assign· October 2020

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RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.
Jorge Pedro López-Alonso, Tatsuya Kaminishi, Takeshi Kikuchi, Yuya Hirata, Idoia Iturrioz, Sean R Connell

Nucleic Acids Res· June 2017

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Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Jorge P López-Alonso, Attilio Fabbretti, Tatsuya Kaminishi, Idoia Iturrioz, Letizia Brandi, Sean R Connell

Nucleic Acids Res· February 2017

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The Novel Aminomethylcycline Omadacycline Has High Specificity for the Primary Tetracycline-Binding Site on the Bacterial Ribosome.
Corina G Heidrich, Sanya Mitova, Andreas Schedlbauer, Sean R Connell, Paola Fucini

Antibiotics (Basel)· September 2016

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Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding.
Attilio Fabbretti, Andreas Schedlbauer, Letizia Brandi, Tatsuya Kaminishi, Anna Maria Giuliodori, Sean R Connell

Proc Natl Acad Sci U S A· April 2016

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Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.
Tatsuya Kaminishi, Andreas Schedlbauer, Attilio Fabbretti, Letizia Brandi, Borja Ochoa-Lizarralde, Sean R Connell

Nucleic Acids Res· November 2015

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Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome.
Andreas Schedlbauer, Tatsuya Kaminishi, Borja Ochoa-Lizarralde, Neha Dhimole, Shu Zhou, Sean R Connell

Antimicrob Agents Chemother· May 2015

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Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
Luciano Ciccarelli, Sean R Connell, Mathias Enderle, Deryck J Mills, Janet Vonck

Structure· July 2013

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Solid-state NMR enhanced by dynamic nuclear polarization as a novel tool for ribosome structural biology.
Ioannis Gelis, Veronika Vitzthum, Neha Dhimole, Marc A Caporini, Andreas Schedlbauer, Sean R Connell

J Biomol NMR· June 2013

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Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.
Andreas H Ratje, Justus Loerke, Aleksandra Mikolajka, Matthias Brünner, Peter W Hildebrand, Sean R Connell

Nature· December 2010

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GTPase activation of elongation factor EF-Tu by the ribosome during decoding.
Jan-Christian Schuette, Frank V Murphy, Ann C Kelley, John R Weir, Jan Giesebrecht, Sean R Connell

EMBO J· March 2009

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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning.
Daniel N Wilson, Frank Schluenzen, Joerg M Harms, Agata L Starosta, Sean R Connell

Proc Natl Acad Sci U S A· September 2008

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A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation.
Sean R Connell, Maya Topf, Yan Qin, Daniel N Wilson, Thorsten Mielke

Nat Struct Mol Biol· September 2008

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Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.
Joerg M Harms, Daniel N Wilson, Frank Schluenzen, Sean R Connell, Torsten Stachelhaus

Mol Cell· April 2008

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A dedicated translation factor controls the synthesis of the global regulator Fis.
Róisín M Owens, Gareth Pritchard, Paul Skipp, Michelle Hodey, Sean R Connell

EMBO J· October 2007

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